Develops groundbreaking cancer treatment and files patent.

The student team from Tel Aviv University (TAU) achieved a remarkable milestone by winning a gold medal at the prestigious IGEM (International Genetically Engineered Machine) competition held recently in Paris. This renowned competition focuses on synthetic biology. The team conducted pioneering research aimed at developing a treatment for patients with currently incurable cancers, thereby introducing a new dimension to cancer therapy. They have also filed a patent application for their innovative work.

About IGEM

IGEM is a global competition in synthetic biology where teams conceptualize innovative ideas to address challenges in the field. These ideas are then realized through a combination of engineering, biological, and computational tools, akin to a startup development process. The judging panel consists of researchers and scientists with expertise in the field, many of whom are past IGEM participants or mentors. This year, over 400 teams from around the world competed.

Tailored and Engineered Cancer Therapies for Terminal Patients

This year, TAU’s IGEM team included outstanding students from diverse disciplines such as engineering, life sciences, medicine, and exact sciences. Working together, they conducted advanced research in synthetic biology. The team’s groundbreaking development, showcased in the competition, is an innovative method called Precise RNA Oncotherapy (PROtech). This approach enables the design of personalized cancer therapies for patients with currently incurable cancers.

The project aims to provide tailored treatments even for patients whose cancer cell mutations do not alter protein structures. Current treatments rely on identifying cancer cells based on altered proteins, making this a revolutionary approach with immense potential. The development incorporates advanced computational models with enhanced performance compared to prior leading research, and the team is working on a groundbreaking paper in the field.

Overcoming Challenges

Professor Tamir Tuller, the academic advisor of the team from TAU’s Faculty of Engineering, shared: “This past year was especially challenging. We began our work in November despite the academic year being delayed until January. Many team members were on military reserve duty, and there was significant uncertainty about our ability to complete the project on time”.

Promoting Synthetic Biology to High School Students

In addition to their research, the team aimed to make synthetic biology accessible to high school students across Israel. They organized a national synthetic biology competition for high school students and contributed to establishing a synthetic biology program within the ORT high school network, with plans to train hundreds of students in the coming year.

Interest from Biotech and Pharma Companies

“Our development has already sparked significant interest from biotech and pharma companies, and we’ve filed a patent application with the help of Ramot, Tel Aviv University’s technology transfer company”, Professor Tuller shared. He added: “In these challenging times, the students brought immense pride to Tel Aviv University and Israel. Beyond the gold medal, they also gained valuable academic experience and entrepreneurial skills that will benefit them in academia, industry, and society. I want to thank Startup Nation Central and TAU’s Entrepreneurship Center for the excellent training they provided our students in entrepreneurship”.

TAU’s IGEM 2024 Team Members:

• Shani Elimelech (Fleischman Faculty of Engineering, Wise Faculty of Life Sciences).
• Gal Schwartz (Wise Faculty of Life Sciences).
• Daniel Ben Harosh (Fleischman Faculty of Engineering).
• Rotem Gal (Fleischman Faculty of Engineering, Wise Faculty of Life Sciences).
• Oren Ben Moshe (Faculty of Exact Sciences).
• Netanel Erlich (Faculty of Exact Sciences, Wise Faculty of Life Sciences).
• Peleg Bezek (Fleischman Faculty of Engineering, Wise Faculty of Life Sciences).
• Tal Shemesh (Fleischman Faculty of Engineering, Wise Faculty of Life Sciences).
• Nav Zvi (Faculty of Medical & Health Sciences).
• Yoni Klein (Wise Faculty of Life Sciences).
• Itay Fabian (Faculty of Medical & Health Sciences)
• Marana Abboud (Faculty of Medical & Health Sciences).