Antibacterial fillings from TAU may combat recurring tooth decay

Written on |

New material may prevent one of the costliest and most prevalent bacterial diseases in the world

Tooth decay is among the costliest and most widespread bacterial diseases. Virulent bacteria cause the acidification of tooth enamel and dentin, which, in turn, causes secondary tooth decay.

A new study by Tel Aviv University researchers finds potent antibacterial capabilities in novel dental restoratives, or filling materials. According to the research, the resin-based composites, with the addition of antibacterial nano-assemblies, can hinder bacterial growth and viability on dental restorations, the main cause of recurrent cavities, which can eventually lead to root canal treatment and tooth extractions.

 

Research for the study was led by Dr. Lihi Adler-Abramovich and TAU doctoral student Lee Schnaider in collaboration with Prof. Ehud Gazit, Prof. Rafi Pilo, Prof. Tamar Brosh, Dr. Rachel Sarig and colleagues from TAU’s Maurice and Gabriela Goldschleger School of Dental Medicine and George S. Wise Faculty of Life Sciences. It was published in ACS Applied Materials & Interfaces on May 28.

 

Can your fillings fight germ?


“Antibiotic resistance is now one of the most pressing healthcare problems facing society, and the development of novel antimicrobial therapeutics and biomedical materials represents an urgent unmet need,” says Dr. Adler-Abramovich. “When bacteria accumulate on the tooth surface, they ultimately dissolve the hard tissues of the teeth. Recurrent cavities — also known as secondary tooth decay — at the margins of dental restorations results from acid production by cavity-causing bacteria that reside in the restoration-tooth interface.”

 

This disease is a major causative factor for dental restorative material failure and affects an estimated 100 million patients a year, at an estimated cost of over $30 billion.

 

Historically, amalgam fillings composed of metal alloys were used for dental restorations and had some antibacterial effect. But due to the alloys’ bold color, the potential toxicity of mercury and the lack of adhesion to the tooth, new restorative materials based on composite resins became the preferable choice of treatment. Unfortunately, the lack of an antimicrobial property remained a major drawback to their use.

 

“We’ve developed an enhanced material that is not only aesthetically pleasing and mechanically rigid but is also intrinsically antibacterial due to the incorporation of antibacterial nano-assemblies,” Schnaider says. “Resin composite fillings that display bacterial inhibitory activity have the potential to substantially hinder the development of this widespread oral disease.”

 

From nano materials to major breakthroughs


The scientists are the first to discover the potent antibacterial activity of the self-assembling building block Fmoc-pentafluoro-L-phenylalanine, which comprises both functional and structural subparts. Once the researchers established the antibacterial capabilities of this building block, they developed methods for incorporating the nano-assemblies within dental composite restoratives. Finally, they evaluated the antibacterial capabilities of composite restoratives incorporated with nanostructures as well as their biocompatibility, mechanical strength and optical properties.

 

“This work is a good example of the ways in which biophysical nanoscale characteristics affect the development of an enhanced biomedical material on a much larger scale,” Schnaider says.

 

“The minimal nature of the antibacterial building block, along with its high purity, low cost, ease of embedment within resin-based materials and biocompatibility, allows for the easy scale-up of this approach toward the development of clinically available enhanced antibacterial resin composite restoratives,” Dr. Adler-Abramovich says.

 
The researchers are now evaluating the antibacterial capabilities of additional minimal self-assembling building blocks and developing methods for their incorporation into various biomedical materials, such as wound dressings and tissue scaffolds.

Related posts

Medicinal Cannabis Oil Effective for Treating Autism

December 22, 2021

TAU Students Racing Towards a Greener Campus

December 21, 2021

Parent Smartphone Use Could Harm Child Development

December 20, 2021

Breakthrough TAU Discovery Key to Reversing ALS

December 17, 2021

Experimental Drug Displays Effectiveness in Treating Symptoms of Autism and Alzheimer’s Disease

December 16, 2021

New Ethical Code for World Research of Ancient DNA

December 15, 2021

Saving Lives with Artificial Intelligence

December 9, 2021

TAU Experts on Omicron: “Don’t Panic”

December 7, 2021

Britain and Israel Team Up on Challenge of Healthy Ageing

November 11, 2021

TAU Researchers Identify COVID Proteins that Cause Strokes and Heart Attacks

November 8, 2021

Help A Friend Out?

October 7, 2021

Can’t Multitask Anymore?

October 6, 2021

Why Do We Squabble Over The AC?

October 5, 2021

The Immune System’s Double Agents

October 5, 2021

Recruiting ‘Fighting Cells’ to Destroy Tumors

September 14, 2021

TAU Team Reverses Early Signs of Alzheimer’s

September 10, 2021

Victoria

Tok Corporate Centre, Level 1,
459 Toorak Road, Toorak VIC 3142
Phone: +61 3 9296 2065
Email: office@aftau.asn.au

New South Wales

P.O. Box 4044, Maroubra South,
NSW 2035
Phone: +61 418 465 556
Email: davidsolomon@aftau.org.au

Western Australia

P O Box 36, Claremont,
WA  6010
Phone: :+61 411 223 550
Email: clivedonner@thelinqgroup.com