Author: AUFTAU

Unearthing Ancient Intelligence

Written by AUFTAU on 23 July 2023. Posted in Newsroom.

A new study from Tel Aviv University and Tel-Hai College solves an old mystery: Where did early humans in the Hula Valley, in northern Israel, get flint to make the prehistoric tools known as hand axes? The researchers applied advanced methods of chemical analysis and AI to identify the geochemical fingerprints of hand axes from the Hula Valley’s oldest prehistoric sites, Ma’ayan Barukh and Gesher Benot Ya’aqov. Their findings indicate that the raw material came from exposures of high-quality flint in the Dishon Plateau, about 20km to the west, and hundreds of meters above the Hula Valley. The researchers: “Our findings indicate that these early humans had high social and cognitive abilities: they were familiar with their surroundings, knew the available resources, and made great efforts to procure the high-quality raw materials they needed. For this purpose, they planned and carried out long journeys, and transferred this essential knowledge to subsequent generations.”

“Our findings indicate that early humans were highly capable: they planned and implemented complex strategies and passed on essential information from one generation to the next.” – The researchers

Early Humans’ Versatile “Swiss Army Knife”

The study was led by Dr. Meir Finkel of the Department of Archaeology and Ancient Near East Cultures, Tel Aviv University and Prof. Gonen Sharon of the MA Program in Galilee Studies, Tel-Hai College, in collaboration with Prof. Erez Ben-Yosef, Tel Aviv University, Dr. Oded Bar and Dr. Yoav Ben Dor, the Geological Survey of Israel, and Ofir Tirosh, the Hebrew University. The paper was published in Geoarchaeology.

Dr. Finkel: “The Hula Valley, located along the Dead Sea Transform Rift, is well known for its many prehistoric sites, the oldest of which date back to 750,000 years before present (YBP). The valley offered early humans rich sources of water, vegetation, and game, right on the northward migration route from Africa – the Great African Rift Valley. These early inhabitants left behind them many artifacts, including thousands of hand axes – flint stones chiseled to fit the human hand. One of the earliest and most universal tools produced by humans, the hand axe may have served as a multipurpose ‘penknife’ for many different tasks, from cutting game meat to digging for water and extracting roots. It was used in many different parts of the Old World, in Africa, Asia, and Europe, for about 1.5 million years.”

“One of the earliest and most universal tools produced by humans, the hand axe may have served as a multipurpose ‘penknife’ for many different tasks, from cutting game meat to digging for water and extracting roots.” – Dr. Meir Finkel

In the present study the researchers looked for the source of the raw material used to produce thousands of hand axes found at two prehistoric sites in the Hula Valley: Gesher Benot Ya’aqov, dated to 750,000 YBP and Ma’ayan Barukh, dated to 500,000 YBP, both Acheulian. Prof. Sharon: “Approximately 3,500 hand axes were found scattered on the ground at Ma’ayan Barukh, and several thousands more were discovered at Gesher Benot Ya’aqov. The average hand axe, a little over 10cm long and weighing about 200g, was produced by reducing stones that are five times larger – at least 1kg of raw material. In other words, to make the 3,500 hand axes found at Ma’ayan Barukh alone, early humans needed 3.5 tons of flint. But where did they obtain such a huge amount of flint? Many researchers have tried to answer this question, but our study was the first to use innovative 21st century technologies: advanced chemical analysis and an AI algorithm developed specifically for this purpose.”

The Gesher Benot Ya’aqov area

20 Kilometer Hikes Across Diverse Terrain

The researchers took samples from 20 hand axes – 10 from Gesher Benot Ya’aqov and 10 from Ma’ayan Barukh, ground them into powder and dissolved the powder in acid in a clean lab. For each sample they measured the concentration of approximately 40 chemical elements, using an ICP-MS (inductively coupled plasma mass spectrometer), a state-of-the-art device that accurately measures the concentration of dozens of elements, down to a resolution of one particle per billion.

In addition, in order to locate possible flint sources available to the Hula Valley’s prehistoric inhabitants, the researchers conducted a field survey covering flint exposures in the Safed Mountains, Ramim Ridge, Golan Heights, and Dishon Plateau, as well as cobbles from streams draining into the Hula Valley: the Jordan, Ayun, Dishon, Rosh Pina, and Mahanayeem. This methodical survey was combined with a comprehensive literature review led by Dr. Bar of the Geological Survey of Israel. Flint samples collected from all potential sources were then analyzed using ICP-MS technology to enable comparison with the hand axes. A novel computational approach specially adapted by Dr. Ben Dor of the Geological Survey of Israel was used for this comparison.

Dr. Ben Dor: “The complex process, from collecting and preparing the samples to the chemical analysis, produced a very large amount of data for each sample. To enable optimal matching between data from the archaeological artifacts and data from the flint exposures, we developed a dedicated algorithm based on several computational steps, alongside machine learning models. Thus, we were able to classify the archaeological artifacts according to the database derived from the geological samples.”

“To procure suitable raw materials for producing their vital hand axes, [humans living in the Hula Valley hundreds of thousands of years ago] planned and carried out 20km hikes that included an ascent from 70 to 800 meters above sea level.” Prof. Erez Ben-Yosef

Dr. Finkel: “Through the computational process we discovered that all 20 archaeological artifacts were made of flint from a single source: the Dishon Plateau’s flint exposures dating back to the Eocene geological epoch, about 20km west of the Gesher Benot Ya’aqov and Ma’ayan Barukh sites. At the Dishon Plateau we also found a prehistoric flint extraction and reduction complex, indicating that the place served as a flint source for hundreds of thousands of years. In addition, we demonstrated that cobbles from streams draining into the Hula Valley were too small to be used as raw material for hand axes, ruling out this possibility.”

Prof. Ben-Yosef: “Our findings clearly indicate that humans living in the Hula Valley hundreds of thousands of years ago, probably hominids of the homo erectus species, possessed high cognitive and social capabilities. To procure suitable raw materials for producing their vital hand axes, they planned and carried out 20km hikes that included an ascent from 70 to 800 meters above sea level. Moreover, they passed on this important knowledge from one generation to the next, over many millennia. All these suggest a high level of sophistication and ability, which modern researchers do not usually attribute to prehistoric humans from such an early period.”

From left: Dr. Meir Finkel and Prof. Erez Ben Yosef

Barbie Buzz: Mattel CEO Shares Branding Wisdom with Tel Aviv University Students

Written by AUFTAU on 23 July 2023. Posted in Newsroom.

The movie Barbie, based on the iconic doll created by American toy company Mattel, premiered this weekend in movie theaters worldwide to much critical acclaim. The movie’s release marks a significant point in the transformation that the long-established company has undergone in recent years under the leadership of Ynon Kreiz, Mattel’s Chairman and CEO.

Ahead of the premier, Kreiz, a Tel Aviv University alumnus, met with the University’s students to discuss the power of transformative leadership and share his personal story. “It’s an honor and a privilege for me to speak here today, having come full circle,” he said.

Kreiz began his career in the world of media after completing his undergraduate studies at TAU’s Coller School of Management and an MBA at UCLA. “The studies at TAU were of the highest level—they prepared me for graduate school […] and helped me to continue the journey onwards from there,” Kreiz told his audience at the beginning of the talk, explaining the reasons he chose TAU after his military service.

“The studies at TAU were of the highest level—they prepared me for graduate school […] and helped me to continue the journey onwards from there.” – Ynon Kreiz

From Barbie the Doll to Barbie, the Movie

Kreiz went on to discuss the transformation that Mattel has undergone under his leadership in recent years, going from a manufacturer of toys to a media company that offers its well-known and beloved brands on a broad range of platforms. He emphasized that the key to success in leading a large towards change is the correct choice of the management team and creating an environment that enables the team to excel.

“No CEO can know everything in every area and take care of every issue,” he explained. “My most important function is to choose a strong management team, to lead them, to encourage them to respond quickly to events in the market, and to build together with them a flexible and fast-moving organization that will know how to compete and change. You have to believe in the talents of the team and let them work, but at the same time if you feel that something is not working – you have to make cuts quickly and not leave people in positions for which they are not suited.”

Ynon Kreiz met with TAU students to discuss the power of transformative leadership and share his personal story

“My most important function is to choose a strong management team, to lead them, to encourage them to respond quickly to events in the market, and to build together with them a flexible and fast-moving organization that will know how to compete and change.” – Ynon Kreiz

Kreiz was the fourth CEO at Mattel in almost five years, which indicated the difficulties the company experienced at the time, with years of stagnancy and heavy losses. “Mattel has strong brands. In the area of children’s toys it comes right after Disney in my opinion,” he said, “and my challenge was to lead it from being a company that perceives itself as a manufacturer of toys to being a company that manages brands; from a company that sells to customers, to a company that manages relations with supporters. We did it without giving up on the core business of toys, by expanding into television, movies, parks, and music, and in general into customer experiences based on our brands.”

Kriez discussed the organizational and structural challenges he and his management team faced, having to cut many workplaces, close factories and massively reorganize the company’s structure. “Yet we made sure to keep the morale of the employees who were retained high and committed to the new goals,” he said. “We did it by defining a clear and simple goal for the company: creating innovative and entertaining experiences for children. I cut down the vision statement of the company to a single page, so that every employee could relate to it. In addition, we gave the employees freedom and responsibility, for instance in choosing unlimited vacations for themselves, coordinated with the manager.”

According to Kreiz, another important message that he imprinted at Mattel was that alongside the financial goals, the company had to operate responsibly: “We have a real influence on society,” he said. “We work with children and we help in forming the future.”

The Personal Story

Kreiz also talked about what it takes to succeed in today’s business world. He said that one of the most important things he learned over the years was to be prepared to acknowledge his mistakes and to correct them quickly – without dwelling on the past. “You failed? Correct it and move on. And that also applies to success. I don’t think it is right to dwell too much on what has happened because time changes very quickly. The important thing is to focus on the present and plan for the future, in accordance with the current situation. You can’t win every battle. The important thing is to keep going.”

“It doesn’t matter what you are doing or at what level. You can always do things better, in a more innovative way. That’s the way to stand out and move forward.” – Ynon Kreiz

Kreiz said that despite his many years in the USA he still brings to his job traits that many perceive as Israeli. “I am a ‘tachles’ person–and you won’t find a word for it in English. The closest I can think of is ‘goal-oriented’. I strive to define goals and to work to achieve them, to make things happen. I don’t know if that’s because I am Israeli, but that’s the way I am.”

Kreiz recommended to students in the audience that they plan their future with a focus on innovation. “It doesn’t matter what you are doing or at what level. You can always do things better, in a more innovative way. That’s the way to stand out and move forward.”

Researchers Produce Highly Efficient, Low-cost “Green” Hydrogen

Written by AUFTAU on 17 July 2023. Posted in Newsroom.

Tel Aviv University researchers have achieved a groundbreaking milestone by successfully producing highly efficient and low-cost “green” hydrogen. By harnessing the power of green electricity and utilizing a highly efficient biocatalyst, this innovative process generates hydrogen without any air pollution.

Hydrogen plays a vital role as raw material in both agriculture and industry. However, most of the hydrogen produced globally, approximately 95%, falls in the “black” or “gray” category. These types of hydrogen are derived from coal or natural gas, emitting a significant 9-12 tons of carbon dioxide for every ton of hydrogen produced.

Over 90% Efficiency

The new method was developed by doctoral student Itzhak Grinberg and Dr. Oren Ben-Zvi, under the guidance of Prof. Iftach Yacoby of the School of Plant Sciences and Food Security at the Faculty of Life Sciences and Prof. Lihi Adler-Abramovich of the School of Dental Medicine and the Center for Nanoscience and Nanotechnology. The promising research results were published in the prominent journal Carbon Energy, focusing on advanced materials and technology for clean energy and CO2 emission reduction.

“Hydrogen is very rare in the atmosphere,” explains Itzhak Grinberg, “although it is produced by enzymes in microscopic organisms, which receive the energy for this from photosynthesis processes. In the lab, we ‘electrify’ those enzymes, that is, an electrode provides the energy instead of the sun. The result is a particularly efficient process, with no demand for extreme conditions, that can utilize electricity from renewable sources such as solar panels or wind turbine. However, the enzyme ‘runs away’ from the electric charge, so it needs to be held in place through chemical treatment. We found a simple and efficient way to attach the enzyme to the electrode and utilize it.”

The researchers used a hydrogel (a water-based gel) to attach the enzyme to the electrode and were able to produce green hydrogen using a biocatalyst, and with over 90% efficiency; that is, over 90% of the electrons introduced into the system were deposited in the hydrogen without any secondary processes.

“We hope that in the future, it will be possible to employ our method commercially, to lower the costs, and to make the switch towards using green hydrogen in industry, agriculture, and as a clean energy source.” – Dr. Oren Ben-Zvi

Prof. Iftach Yacoby explains that, “The material of the gel itself is known, but our innovation is to use it to produce hydrogen. We soaked the electrode in the gel, which contained an enzyme for producing hydrogen, called hydrogenase. The gel holds the enzyme for a long time, even under the electric voltage, and makes it possible to produce hydrogen with great efficiency and at environmental conditions favorable to the enzyme — for example, in salt water, in contrast to electrolysis, which requires distilled water.

Prof. Lihi Adler-Abramovich adds: “Another advantage is that the gel assembles itself — you put the material in water, and it settles into nanometric fibers that form the gel. We demonstrated that these fibers are also able to stick the enzyme to the electrode. We tested the gel with two other enzymes, in addition to the hydrogenase, and proved that it was able to attach different enzymes to the electrode.”

“Today, ‘green’ hydrogen is produced primarily through electrolysis, which requires precious and rare metals such as platinum along with water distillation, which makes the green hydrogen up to 15 times more expensive than the polluting ‘grey’ one, says Dr. Oren Ben-Zvi. “We hope that in the future, it will be possible to employ our method commercially, to lower the costs, and to make the switch towards using green hydrogen in industry, agriculture, and as a clean energy source.”

Researchers Induce Cancer Cell “Suicide”

Written by AUFTAU on 17 July 2023. Posted in Newsroom.

For the first time in the world: researchers at Tel Aviv University encoded a toxin produced by bacteria into mRNA (messenger RNA) molecules and delivered these particles directly to cancer cells, causing the cells to produce the toxin – which eventually killed them with a success rate of 50%.

“Our idea was to deliver safe mRNA molecules encoded for a bacterial toxin directly to the cancer cells – inducing these cells to actually produce the toxic protein that would later kill them. It’s like placing a Trojan horse inside the cancer cell.” – Prof. Dan Peer

“It’s like placing a Trojan horse inside the cancer cell”

The groundbreaking study was led by PhD student Yasmin Granot-Matok and Prof. Dan Peer, a pioneer in the development of RNA therapeutics and Head of the Nanomedicine Laboratory at The Shmunis School of Biomedicine and Cancer Research, also serving as TAU’s VP R&D. The study’s results were published in Theranostics.

Prof. Peer explains: “Many bacteria secrete toxins. The most famous of these is probably the botulinum toxin injected in Botox treatments. Another classic treatment technique is chemotherapy, involving the delivery of small molecules through the bloodstream to effectively kill cancer cells. However, chemotherapy has a major downside: it is not selective, and also kills healthy cells. Our idea was to deliver safe mRNA molecules encoded for a bacterial toxin directly to the cancer cells – inducing these cells to actually produce the toxic protein that would later kill them. It’s like placing a Trojan horse inside the cancer cell.”

Prof. Dan Peer

Impressive Results

First, the research team encoded the genetic info of the toxic protein produced by bacteria of the pseudomonas family into mRNA molecules (resembling the procedure in which genetic info of COVID-19’s ‘spike’ protein was encoded into mRNA molecules to create the vaccine). The mRNA molecules were then packaged in lipid nanoparticles developed in Prof. Peer’s laboratory and coated with antibodies – to make sure that the instructions for producing the toxin would reach their target, the cancer cells. The particles were injected into the tumors of animal models with melanoma skin cancer. After a single injection, 44-60% of the cancer cells vanished.

“With a simple injection to the tumor bed, we can cause cancer cells to ‘commit suicide’, without damaging healthy cells. Moreover, cancer cells cannot develop resistance to our technology as often happens with chemotherapy – because we can always use a different natural toxin.” – Prof. Dan Peer

“In our study, the cancer cell produced the toxic protein that eventually killed it,” says Prof. Peer. “We used pseudomonas bacteria and the melanoma cancer, but this was only a matter of convenience. Many anaerobic bacteria, especially those that live in the ground, secrete toxins, and most of these toxins can probably be used with our method. This is our ‘recipe’, and we know how to deliver it directly to the target cells with our nanoparticles. When the cancer cell reads the ‘recipe’ at the other end it starts to produce the toxin as if it were the bacteria itself and this self-produced toxin eventually kills it. Thus, with a simple injection to the tumor bed, we can cause cancer cells to ‘commit suicide’, without damaging healthy cells. Moreover, cancer cells cannot develop resistance to our technology as often happens with chemotherapy – because we can always use a different natural toxin.”

Other contributors to the study included: Dr. Assaf Ezra, Dr. Srinivas Ramishetti, Dr. Preeti Sharma Dr. Gonna Somu Naidu and Prof. Itai Benhar, Head of the Antibody Engineering Lab at the Shmunis School of Biomedicine and Cancer Research at TAU. The study was funded by the Shmunis Family Foundation for Biomedicine and Cancer Research.

Metabolomics – A New Frontier in Preventive Medicine

Written by AUFTAU on 13 July 2023. Posted in Newsroom.

Tel Aviv University’s new Metabolite Medicine Division at the BLAVATNIK Center for Drug Discovery poised to revolutionize the field.

Even the simplest blood tests of today – which monitor about 20 substances in our body – have powerful predictive and diagnostic power. For example, high cholesterol suggests possible heart trouble, and abnormal glucose could indicate pre-diabetes.

Now imagine that routine and low-cost bloodwork could check for thousands of compounds all at once, as well as calculate the balance between them. Such a real-time status check would provide doctors with unparalleled knowledge for diagnosing patients and creating personalized profiles for the most effective treatment of disease.

“Metabolomics is poised to revolutionize the field of preventive medicine. It holds tremendous potential (…) not only for detecting diseases but also for enabling individuals to proactively monitor their overall physiological well-being even before the onset of illness.” – Prof. Ehud Gazit

The Super Blood Test

We are entering such an era at TAU’s new Metabolite Medicine Division at the BLAVATNIK CENTER for Drug Discovery. This suite of labs is the most advanced at an Israeli university for the emerging science of metabolomics – the study of small molecules called metabolites that our bodies produce every second of our lives as part of ongoing cell processes. Sometimes, all that is required is to identify the one metabolite culprit that is throwing the body off balance.

“Metabolomics is poised to revolutionize the field of preventive medicine. It holds tremendous potential as a cornerstone and indispensable tool, not only for detecting diseases but also for enabling individuals to proactively monitor their overall physiological well-being even before the onset of illness,” explains Prof. Ehud Gazit, the Founding Director of the Metabolomic Medicine division.

“Unlike genetics, which cannot be easily altered, the composition of metabolites provides a valuable reflection of the body’s physiological state, making it possible to optimize towards an ideal state through dietary interventions, physical activity, and lifestyle modifications,” he says.

“The establishment of the Metabolite Medicine division at the BLAVATNIK CENTER for Drug Discovery is highly important for the entire biomed framework of Tel Aviv University.” – Dr. Ludmila Bozhansky

Driving Real-Life Implementation

Using state-of-the-art equipment, scientists will be able to identify specific metabolic signatures in laboratory and patient cell culture samples, learn about their mechanisms of action, and develop AI-aided data analysis tools. The ultimate aim of the Metabolite Division is to connect promising university discoveries with Israeli hospitals for clinical samples and testing, and with the pharma industry for creating or repurposing drugs.

“The establishment of the Metabolite Medicine division at the BLAVATNIK CENTER for Drug Discovery is highly important for the entire biomed framework of Tel Aviv University,” says Dr. Ludmila Buzhansky, the Managing Director of the BLAVATNIk Center for Drug Discovery. “By leveraging the capabilities of metabolomics and benefiting from the exceptional expertise now available at TAU in this field, our researchers develop interdisciplinary collaborations that drive innovation and knowledge dissemination across diverse domains within the university community and beyond.”

Source: TAU Review

Older Bats do Suffer from Age-related Hearing Loss

Written by AUFTAU on 13 July 2023. Posted in Newsroom.

A new study from Tel Aviv University disproves the prevailing scientific assumption that bats are immune to age-related hearing loss. This assumption led researchers to mistakenly believe that because hearing is so critical to the bats’ echolocation system, they preserve a good hearing ability, enabling orientation even at an advanced age.

“Turn left at the next tree! Hey, did you catch that??”

In the present study the researchers found that the bats’ sense of hearing does in fact deteriorate with age, but at a relatively slow rate – compared to humans and other mammals. Since they live in very noisy colonies, where more rapid hearing loss might have been expected, the researchers hypothesize that the bats may have developed special adaptations that slow down the process.

The study was led by PhD student Yifat Tarnovsky from the laboratory of neuro-ecologist Prof. Yossi Yovel of the School of Zoology at The George S. Wise Faculty of Life Sciences, Head of TAU’s Sagol School of Neuroscience, in collaboration with Prof. Karen Avraham, Dean of TAU’s Faculty of Medicine, Dr. Shahar Taiber from her lab and Prof. Jerry Wilkinson from the University of Maryland. The paper was published in Life Science Alliance.

Prof. Yovel explains that the ability to discern high frequencies is critical for the survival of bats, which rely on it to orient themselves in their surroundings. However, to date no study has systematically examined the effects of aging on hearing in bats.

The researchers used DNA methylation accumulation to assess the age of 47 wild Egyptian fruit bats (Rousettus aegyptiacus), and then tested their hearing by monitoring auditory brainstem responses to sounds of varying frequency and intensity. The recordings clearly indicated age-related hearing loss, and just like in humans, this deterioration was more marked in the higher frequencies. The rate of deterioration was found to be similar to hearing loss observed in aging humans.

Prof. Yossi Yovel with two winged friends

Additional tests showed that like in humans, hearing loss in bats is related to the structure and function of the cochlea, alongside slower processing by the auditory nerve. Tarnovsky explains: “In humans, this last symptom can affect speech comprehension. In older bats it can be detrimental to echolocation. The Egyptian fruit bats we studied rely on echolocation to perform various tasks, but whenever possible they also rely substantially on eyesight. Therefore, our tests should be replicated in bats with poor eyesight, that rely almost exclusively on echolocation to orient themselves.”

New Discoveries About the Process of Hearing Loss

The researchers assume that one cause of hearing loss in Egyptian fruit bats could be cumulative exposure to high noise levels in their environment. Like many other bat species, Egyptian fruit bats live in large colonies and use loud and frequent social vocalizations to communicate. By placing several microphones inside the fruit bats’ cave, Tarnovsky and her colleagues discovered that the bats are frequently exposed to a sound intensity of over 100 dB, equal to that of a motorcycle or power saw. Surprisingly, the loudest noise was found in low frequencies, while the tests indicated that hearing loss occurs mostly in high frequencies.

“The relatively slow rate of age-related hearing loss (similar to the rate in humans) despite lifelong exposure to very high noise levels may indicate that bats have developed special adaptations for coping with their noisy surroundings,” says Prof. Yovel. The researchers hope that understanding these adaptations can provide new insights about the mechanisms of age-related hearing loss in humans.

Operation Guardian of the Walls: Women, Young People and Residents of the South Paid the Heaviest Price

Written by AUFTAU on 12 July 2023. Posted in Newsroom.

During Operation Guardian of the Walls, which took place in May 2021, researchers from Tel Aviv University carried out a groundbreaking study by equipping Israelis with smartwatches and a dedicated mobile application. The study aimed to examine the impact of the operation on the well-being of citizens by monitoring various objective and subjective indicators. The findings revealed that residents of Israel’s southern region suffered significantly more than the rest of the population.

Assessing Impacts, as well as Resilience

The innovative study was conducted by a team of researchers from Tel Aviv University: Prof. Erez Shmueli, Prof. Dan Yamin, and Ph.D. students Merav Mofaz and Matan Yechezkel of The Iby and Aladar Fleischman Faculty of Engineering; Prof. Noga Kronfeld-Schor of The George S. Wise Faculty of Life Sciences; and Prof. Haim Einat of the Academic College of Tel Aviv-Yafo. The findings of the groundbreaking study were published in the journal Communication Medicine from the Nature group.

According to Prof. Erez Shmueli, the study was part of a broader initiative called PerMed (Personalized Medicine), aimed at early diagnosis of infectious diseases like COVID-19. However, the timing of Operation Guardian of the Walls presented a unique opportunity to examine the physiological and mental changes experienced by civilians during wartime.

By May 2021, the researchers had enrolled 954 Israelis in the experiment, equipping them with smartwatches to assess the impact of the war on the home front. The data collected from the smartwatches and participants’ reports through the app revealed a significant deterioration in various metrics during the war compared to normal circumstances. Notably, after the war ended, all indicators returned to their previous levels on average, showcasing the mental resilience of Israelis. Nevertheless, the researchers observed notable differences among Israeli citizens: with residents of the southern areas (near Gaza), exposed to frequent and dangerous rocket attacks, enduring more significant mental and physiological effects compared to those in the central regions. Furthermore, central region residents suffered more than those in the north.

“In future research, it is crucial to identify individuals who experienced significant adversity during the war and did not fully recover following its conclusion. We believe that providing prompt and targeted support to these individuals may prevent the development of post-traumatic stress disorder (PTSD).” – Prof. Erez Shmueli

The findings highlighted several key differences among the citizens. For example, residents of the southern areas spent more time (6.2 hours) looking at their screens compared to central region residents (5.3 hours), and central region residents spent more screen time than those in the north (5 hours). Similar patterns emerged in other metrics, such as mood (3.24 in the south versus 3.45 in the center and 3.75 in the north, on a scale of 1 to 5), stress (2.8 in the south versus 2.6 in the center and 2.3 in the north, on a scale of 1 to 5), physical activity (20 minutes in the south compared to about 34 minutes in the center and in the north), sleep duration (6.1 hours in the south compared to 6.2 hours in the center and 6.5 hours in the north) and quality of sleep (2.9 in the south compared to 3.3 in the center and 3.5 in the north, on a scale of 1 to 5). Women and young people experienced more deviation from their normal patterns during the conflict compared to men and adults.

Since Operation Guardian of the Walls, there have been subsequent rounds of fighting between Israel and factions in Gaza, as well as Russia’s invasion of Ukraine. Prof. Shmueli believes that wearable technology holds immense potential in monitoring the consequences of such conflicts and providing aid to populations in need: “In the past, wars were fought at the borders,” says Prof. Shmueli. “Today, they are fought deep within the country. Therefore, monitoring the resilience of citizens is crucial, both as groups and as individuals. The state needs to know what happens to its citizens during war, as well as provide special support to groups that are more prone to harm. In future research, it is crucial to identify individuals who experienced significant adversity during the war and did not fully recover following its conclusion. We believe that providing prompt and targeted support to these individuals may prevent the development of post-traumatic stress disorder (PTSD).”

Due to Climate Change, More Animals will Become Extinct Outside of Nature Reserves than Within Them

Written by AUFTAU on 12 July 2023. Posted in Newsroom.

A new international study has found that amphibians and reptiles inhabiting the world’s nature reserves, or Protected Areas (PAs), will be better protected against climate change than species found outside of these areas, but are still likely to be harmed.

The research findings provide evidence, on a global scale, of the crucial role Protected Areas play in conserving amphibian and reptile biodiversity under human-induced climate change scenarios. The study reveals that more animals will become extinct because of climate change outside of Protected Areas than inside them — in the world in general and on most individual continents.

Protected Areas as Refuges

Prof. Shai Meiri of Tel Aviv University’s School of Zoology, The George S. Wise Faculty of Life Sciences and The Steinhardt Museum of Natural History took part in the study, in collaboration with leading researchers from 19 countries. The study was published in the prestigious journal Nature Communications.

“Approximately 91% of the amphibian and reptile species we examined are protected, to some degree, in Protected Areas, and this proportion will remain unchanged under future climate change.” – Prof. Shai Meiri

The purpose of the study was to evaluate the effectiveness of existing Protected Areas in protecting the amphibians and reptiles living within them under future climate scenarios, as well as to identify conservation gaps in order to outline a road map for the development of conservation actions based on the current global network of Protected Areas.

“In this study, we collected distribution data for more than 14,000 species of amphibians and reptiles — about 70% of the known species — to perform a global assessment of the conservation effectiveness of Protected Areas in an era of climate change, using species distribution models,” explains Prof. Meiri. “Our analyses revealed that approximately 91% of the amphibian and reptile species we examined are protected, to some degree, in Protected Areas, and that this proportion will remain unchanged under future climate change. Furthermore, species protected in Protected Areas will lose smaller portions of their distribution ranges inside the nature reserve than outside of them. Therefore, the proportion of species within reserves is expected to increase.”

Relative Optimism

However, Prof. Meiri points out, “We predict that more than 300 of the amphibian species and 500 of the reptile species we studied will become extinct due to climate change in the coming decades, and probably also hundreds of species for which we did not have sufficient data to model. Our research highlights the importance of Protected Areas in providing refuge for amphibians and reptiles in face of climate change and points out areas where there are not enough nature reserves that can better preserve biodiversity around the world.”

“Despite the relative optimism emerging from the new research, the models still predict extremely high rates of loss of species and habitats due to climate change. Protected Areas do indeed protect the animals living within them, but nothing is foolproof.” – Prof. Shai Meiri

He adds: “We compiled a comprehensive global database with more than 3.5 million observation records spanning 5,403 amphibian species and 8,993 reptile species from online databases, fieldwork data, museum collections, and published references. For all species in our database, we predicted habitat availability according to current (1960–1990) climate data and future scenarios (for the years 2060–2080) at a high spatial resolution (1 km × 1 km) using species distribution models. Then, we evaluated the effectiveness of Protected Areas in conserving amphibians and reptiles by calculating the coverage of their distribution range inside and outside of Protected Areas, as well as the proportion of species for whom a significant portion of their distribution range (for example, 15% or 30%) is protected in PAs under current and future climate conditions (assuming that the future use of the land remains unchanged over the years — that is, that there will be no conversion of nature reserves into agricultural, industrial, or urban areas.)”

Prof. Meiri concludes: “Our evidence shows that the current global network of Protected Areas already plays an important role in preserving the global biodiversity of amphibians and reptiles, and will continue to do so under the expected future climate. However, many species do not live in the existing Protected Areas. These include, for example, many amphibians and reptiles in Mexico, Jamaica, the Andes, West Africa, South Africa, the southern and northern coast of Turkey, Yemen and other places. Moreover, in our study we could create a model for only about two-thirds of reptile and amphibian species. Good models can’t be created for the rarest species, which are known to be more vulnerable to extinction and less protected in Protected Areas. At the same time, it is important to remember that despite the relative optimism emerging from the new research, the models still predict extremely high rates of loss of species and habitats due to climate change. Protected Areas do indeed protect the animals living within them, but nothing is foolproof.”

From a Dark Bunker in Ukraine to Graduation Ceremony at Tel Aviv University

Written by AUFTAU on 12 July 2023. Posted in Newsroom.

Kirill Drik, a master’s degree student at Tel Aviv University’s School of Political Science, Government, and International Affairs, experienced an incredible ordeal during the war between Russia and Ukraine. For ten months, he hid from the Ukrainian army, who sought to recruit him, in a desolate bunker filled with the constant sounds of explosions, rats, and a repugnant stench. Thankfully, his partner made sure to bring him food every day.

Studying in a Dark, Abandoned Shelter

Despite the bunker’s unstable internet, Kirill persevered with his studies using Zoom, with the dedicated support of the University’s Coordinator of Advanced Degrees, the Head of the School, and the entire teaching staff. They were all committed to assisting Kirill in completing his degree even under such challenging circumstances.

Last month, Kirill’s dream became a reality as he proudly stood on the stage of Tel Aviv University, ready to receive his hard-earned degree.

“Russian planes were constantly bombing the area and there were lots of alarms. I was scared and didn’t know if I would ever be able to return to my normal life.” – Kirill Drik

Facing Unimaginable Difficulties

Reflecting on his experience, Kirill shared, “The war in Ukraine presented countless obstacles for me, particularly in meeting course requirements and submitting assignments.” He continued, brimming with excitement, “The bunker in the city of Dnipro, where I recided, was a dark, abandoned shelter with only a small night lamp. The lack of internet access, the terrible smell of sewage, rats scurrying around my feet, and the echoes of explosions constantly haunting the background made it a terrifying environment. The bunker was situated near an ammunition factory, resulting in incessant bombings by Russian planes. I was scared, uncertain whether I would ever return to a normal life.”

The Mission to Graduate Kirill Drik

Just a few months before this dire situation, Kirill had been living in Israel, pursuing his master’s degree at Tel Aviv University’s School of Political Science, Government, and International Affairs.

In 2017, Kirill had immigrated to Israel from Ukraine as a lone soldier and had served full-time in the IDF as a volunteer in a commando unit, despite facing health challenges. After completing his military service, he commenced his studies at Tel Aviv University. In February 2022, during a semester break, he traveled to his hometown, Dnipro, in eastern Ukraine, to visit his parents. However, his stay extended due to his mother’s sudden illness and hospitalization, until February 25th.

“I asked the lecturers to report to us regularly if he missed classes, and we all tried to prepare study materials so he would be prepared for the classes that took place on Zoom.” – Prof. Hanna Lerner

When the war broke out between Russia and Ukraine on the eve of his flight back to Israel, Kirill, holding both Israeli and Ukrainian citizenship, found himself unable to leave. As all citizens were obligated to join the army, he had no choce but to flee and seek refuge in a bunker for ten long months, with his partner providing him essential provisions.

A Ray of Light Amidst Darkness

During those arduous days, Kirill maintained regular contact with Sigal Shachar, the Coordinator of Advanced Degrees at Tel Aviv University’s School of Political Science, Government and International Affairs. Additionally, Professor Hanna Lerner, the Head of the School, wholeheartedly supported Kirill and rallied the entire teaching staff for Operation “Graduation of Kirill Drik “.

Despite the unbearable conditions, confined to the bunker, Kirill persisted with his studies, attending Zoom classes, completing exams, adn working on projects.

Prof. Lerner shares that, “once we learned that Kirill was hiding in Ukraine, it became paramount for us to maintain daily contact wtih him. I requested lecturers to keep us informed if he missed any classes, and we all diligently prepared study materials to ensure he could keep up with the Zoom sessions. It couldn’t have been easy for him, and we are immensely proud of Kirill for his unwavering determination to continue studying, even amid the sounds of shelling and alarms, while hiding in the bunker for days on end.”

“For the rest of my life I will never stop being thankful for everything Tel Aviv University has done for me. I am sure we will meet again when I pursue my Ph.D.” – Kirill Drik

“When I received my degree I felt that I had finally returned to my homeland.” Kirill receives his degree. Pictured with Prof. Hanna Lerner (left) and Sigal Shachar.

Gratefulness and Hope for the Future

After ten challenging months in Ukraine, including four failed attempts to escape through the border, Kirill received a phone call from Sigal who shared the happy news that after much effort the University, in cooperation with Tel Aviv University’s Lowy International School, had managed to arrange all the documents that were missing in order for him to leave Ukraine and return to Israel.

Kirill’s journey came full circle when he finally received his degree, a moment that made him feel like he had returned home. Standing on stage, he received his diploma, accompanied by Prof. Hanna Lerner and Sigal Shachar.

“My homeland is Israel,” Kirill declared. Reflecting on his experience he said, “For the rest of my life, I will forever be grateful for everything Tel Aviv University has done for me. I know we will meet again when I pursue my Ph.D.” With tears of joy, Kirill expressed his gratitude to the audience, stating, “My story is a testament to triumph. Never let anything hold you back. With determination, technology, and the suppport of good-hearted people, you can overcome any obstacle.”

Discovery May Lead to Personalized Medicine for Infectious Diseases

Written by AUFTAU on 12 July 2023. Posted in Newsroom.

In the world of healthcare, personalized medicine has made significant strides in certain disease areas, notably cancer. However, when it comes to infection diseases, the application of personalized medicine tools remains largely unexplored. Thanks to a groundbreaking scientific breakthrough, researchers at Tel Aviv University have set their sights on expanding the realm of personalized medicine to encompass infectious diseases as well. This newfound potential holds the promise of delivering more targeted and effective treatments to patients in need.

Until now, the medical world studied the immune response as a single unit, but a team of researchers at Tel Aviv University discovered a way, using experiments and computational tools, to classify two central components of the immune response that operate as a result of severe infectious disease. The importance of the discovery is that it provides a doorway to the world of personalized medicine in the field of infectious diseases and the provision of more effective treatments for patients. For example, instead of deciding to give a uniform medicine to all patients (i.e. an antibiotic like penicillin) the physician will be able to determine precisely which medicine he should give the patient and at what dosage, according to the classification of the infection based on analysis of the ratio between two key markers found in the patient’s blood.

Infectious Disease

An infectious disease is a condition in which a microorganism (virus, bacterium, or parasite) manages to penetrate and multiply in the human body, causing direct damage to the body’s cells.

The damage to the body may also be indirect, as a result of the reaction of the immune system, for example, the creation of inflammation against the same disease-causing agent (pathogen).

Zooming in on the Immune System

The research was led by Prof. Irit Gat-Viks and Prof. Eran Bacharach, with the doctoral students Ofir Cohn and Gal Yankovitz from the Shmunis School of Biomedicine and Cancer Research in The George S. Wise Faculty of Life Sciences. The study was published in the prestigious journal, Cell Systems.

“From simple blood tests, we can learn a lot about the health status of people who became ill and give them more comprehensive treatment according to the development of the infection in their bodies.” – Prof. Irit Gat-Viks

“In the general population, people react differently to infections, and therefore there is a need for medical tools to indicate how each person is expected to react to a certain infectious disease,” explains Prof. Gat-Viks. She explains that, “until now, there have been only very general indicators to characterize these diseases, such as inflammatory markers, fever, urine tests, etc. Based on these indicators, analyses of the response to the infection that appeared rather uniform can be divided into different responses according to the new classification. In extreme cases, as we saw in the Corona epidemic, a person’s immune response to the virus can result in lethality, and preliminary identification of their response can help us save lives. Our new observations and more precise classification of the inflammatory response has allowed us to identify new indicators and markers in our bloodstream. What all this means is that from simple blood tests, we can learn a lot about the health status of people who became ill and give them more comprehensive treatment according to the development of the infection in their bodies.”

Prof. Eran Bacharach and Prof. Irit Gat-Viks

The researchers were able to observe the response of the immune system with high resolution, and identify two main types of responses. Prof. Bacharach outlines the first response as one in which, “the immune system fights a pathogen that has entered the body,” and the other type and one in which “the damage to the body ‘after the war’ with the pathogen is repaired.” In their research, they used disease models in animals, computational tools, and information collected from people with different markers in their bodies that are indicators of the type of response to the pathogen.

“People with extreme reactions to infection with microorganisms such as viruses or bacteria lack an adequate medical response today.” – Prof. Irit Gat-Viks

Prof. Gat-Viks explains that “in fact, personalized medicine exists today for ‘regular’ diseases such as cancer, but there is almost no use of personalized medicine methods in the field of infectious diseases. People with extreme reactions to infection with microorganisms such as viruses or bacteria lack an adequate medical response today. We believe that thanks to our research, doctors will be able to better diagnose the patient’s condition and, as a result, provide effective treatment that will improve the patient’s chances of recovery. We aim to continue the research and discover more subgroups with different reactions among the population so that we can help doctors make their diagnosis more precise and thus provide proper treatment for their patients.”

Author: AUFTAU

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