Newsroom – Page 26 – Australian Friends of Tel Aviv University

Researchers Identify 100,000 New Types of Viruses

Written by AUFTAU on 27 December 2022. Posted in Newsroom.

A groundbreaking Tel Aviv University study has discovered about 100,000 new types of previously unknown viruses – a ninefold increase in the amount of RNA viruses known to science until now. The viruses were discovered in global environmental data from soil samples, oceans, lakes, and a variety of other ecosystems. The researchers believe that the discovery may help in the development of anti-microbial drugs and in protecting against agriculturally harmful fungi and parasites.

Most Viruses Not Harmful to Humans

The study was led by doctoral student Uri Neri under the guidance of Prof. Uri Gophna of the Shmunis School of Biomedicine and Cancer Research in The George S. Wise Faculty of Life Sciences at Tel Aviv University. The research was conducted in collaboration with the US-based research bodies NIH and JGI, as well as the Pasteur Institute in France. The study was published in the prestigious journal Cell, and comprised data collected by more than a hundred scientists around the world.

Viruses are genetic parasites, meaning they must infect a living cell to replicate their genetic information, produce new viruses, and complete their infection cycle. Some viruses are disease-causing agents that can cause harm to humans (such as the coronavirus), but most viruses do not harm us – some of them even live inside our bodies without us even being aware of it.

“One of the key questions in microbiology is how and why viruses transfer genes between them. We identified several cases in which such gene exchanges enabled viruses to infect new organisms.” Prof. Uri Gophna

Harnessing Viruses for Use in Medicine and Agriculture

Uri Neri says that the study used new computational technologies to mine genetic information collected from thousands of different sampling points around the world: oceans, soil, sewage, geysers, and more. The researchers developed a sophisticated computational tool that distinguishes between the genetic material of RNA viruses and that of the hosts and used it to analyze the big data. The discovery allowed the researchers to reconstruct how the viruses underwent diverse acclimation processes throughout their evolutionary development to adapt to different hosts.

In analyzing their findings, the researchers were able to identify viruses suspected of infecting various pathogenic microorganisms, thus enabling viruses to control them. “The system we developed makes it possible to perform in-depth evolutionary analyses and to understand how the various RNA viruses have developed throughout evolutionary history,” explains Prof. Gophna. “One of the key questions in microbiology is how and why viruses transfer genes between them. We identified several cases in which such gene exchanges enabled viruses to infect new organisms.”

“Furthermore, compared to DNA viruses, the diversity and roles of RNA viruses in microbial ecosystems are not well understood. In our study, we found that RNA viruses are not uncommon in the evolutionary landscape and, in fact, that in some respects they are not that different from DNA viruses. This opens the door for future research, and for a better understanding of how viruses can be harnessed for use in medicine and agriculture.”

Featured image: The researchers (from left to right): Uri Neri and Prof. Uri Gophna

“Requiem for a Whale” Won Best Student Film Award at the IDA Documentary Awards Ceremony

Written by AUFTAU on 25 December 2022. Posted in Newsroom.

Featured image: Ido Weisman on the red carpet (Photo: private collection)

Could a Drone Save Bats from the Terror of Wind Turbine Blades?

Written by AUFTAU on 19 December 2022. Posted in Newsroom.

Every year, wind turbines around the world kill millions of bats and other flying animals that fly into the turbine’s blades. A new study by Tel Aviv University and the University of Haifa offers an original solution to the biological challenge of wind turbine operation and helps prevent harm caused to flying animals, in particular bats: a unique drone-mounted technology that transmits a combination of ultrasonic signals and lights. This deters the bats and leads them to fly at a higher altitude, outside the danger zone, thereby allowing the turbines to continue to operate efficiently and continuously.

“Our study was the first in the world to combine these technologies – RADAR, LIDAR and high-altitude acoustic recorders – to track bats.” Yuval Werber

Innovative Bat Tracking and Signaling

The study was conducted under the leadership of doctoral student Yuval Werber of the Department of Evolutionary and Environmental Biology at the University of Haifa and his two supervisors, Prof. Yossi Yovel, head of Tel Aviv University’s Sagol School of Neuroscience and faculty member of the School of Zoology, and Prof. Nir Sapir, the Head of the Department of Evolutionary and Environmental Biology at the University of Haifa, and in collaboration with the company WinGo Energy and the entrepreneur Gadi Hareli. The article was published in the journal Remote Sensing in Ecology and Conservation, and the study was funded by a research grant from the Israeli Ministry of Energy.

“Wind turbines are considered a promising technology in the field of renewable energy, but their operation involves a variety of biological challenges,” explains Prof. Yossi Yovel. “Today, the only solution to prevent the death of bats is to stop turbine activity at times when the bats are expected to be particularly active. But such interruptions reduce the turbines’ efficiency and the amount of energy they can produce.”

“The advantage of the drone is that it is in constant motion and transmits a combination of visual and acoustic signals designed specifically for bats, warning them of danger. When signals are stationary and constant, animals tend to get used to them and eventually ignore them.”

Yuval Werber shares that, “the study, which is part of my doctoral thesis, was conducted in the Hula Valley, an area with a lot of bat activity. We operated the drone at a height of 100 meters – the average height of the center of a wind turbine, and in motion along a path of about 100 meters, back and forth.”

“To track the bats’ activity, we used RADAR located on the ground, which allowed for tracking at a height of 100 meters and above, and we added a LIDAR device – a laser-based tool that is used to detect objects at short distances, mainly in the automotive industry – for tracking at a lower height. At the same time, we made acoustic recordings of the bats in flight, using receivers placed at three different heights: one meter, 150 meters, and 300 meters. We used a blimp to elevate the receivers. Importantly, our study was the first in the world to combine these technologies – RADAR, LIDAR and high-altitude acoustic recorders – to track bats.”

“On the one hand, it prevents the killing of bats, and on the other hand, it enables the operation of the turbine and the production of green energy in a safe, continuous and efficient manner.” Prof. Yossi Yovel

Effective Bat Repeller

Using a variety of monitoring methods, the researchers compared the bats’ normal activity with their activity in the presence of the drone carrying the deterrent device. The findings were unequivocal – the device succeeded in keeping the bats away. With the drone’s presence, the bats’ activity underneath it decreased by about 40 percent, at a distance of up to about 400 meters. On the other hand, their activity increased above the drone’s altitude of 100 meters, up to 800 meters.

“It appears that the device is effective in repelling bats from its immediate environment – the bats sense the visual and ultrasonic signals it emits and choose to fly over it, as we had hoped,” says Prof. Yovel.

“We hypothesize that if the device is activated near a turbine, it will lead the bats to fly over the turbine and out of harm’s way. This is an effective and easily-implemented solution that is reasonably priced, with great benefit to all parties: on the one hand, it prevents the killing of bats, and on the other hand, it enables the operation of the turbine and the production of green energy in a safe, continuous and efficient manner. We intend to carry out a follow-up experiment on a wind turbine site, in order to test the efficiency of the device under these conditions.”

TAU and Goethe University Establish a Joint Center for the Study of Religious and Interreligious Dynamics

Written by AUFTAU on 19 December 2022. Posted in Newsroom.

Academic collaboration between Israel and Germany is growing, and for the first time, Tel Aviv University in Israel and Goethe University in Frankfurt will establish a joint center for with a focus on interfaith studies. The center will promote research on religion, in particular the monotheistic faiths – a field in which both institutions specialize – with special attention to their mutual interactions at all levels of religious life. The two universities will conduct joint research, hold academic conferences, and train students and researchers in this field.

The agreement for launching the new center was signed in December 2021, during a dedicated “Germany Week” organized at TAU by TAU International and the Student Union of Tel Aviv University. The signing was attended by the German Ambassador to Israel Susanne Wasum-Rainer, TAU President Prof. Ariel Porat, and the President of Goethe University, Prof. Enrico Schleiff.

Twelve months later, the full agreement was signed during an inaugurating two-day international conference at TAU entitled “Thinking Interreligiously.”

“This collaboration includes hundreds of joint research projects as well as hundreds of German students who come to our campus each year. The joint center expands this collaboration in an important new direction and tightens our existing partnership with Goethe University Frankfurt, one of the leading universities in Germany.” Prof. Milette Shamir

Thinking Interreligiously, Together

The conference comprises six working sessions in which six leading scholars in the emerging field of interreligious dynamics will present papers outlining their specific approach to the subject. Each paper will be responded to by pre-assigned expert commentators, followed by an additional hour-long discussion. World-renowned classicist and long standing partner to the interreligious studies initiative, Prof. Simon Goldhill of Cambridge University will deliver a keynote lecture on “The Christian Invention of Time.” The conference concludes with a forward looking round-table discussion on how interreligious studies might impact the study of religion in general.

“Tel Aviv university has a wide network of collaboration with German universities, more than with any other country in Europe,” says Prof. Milette Shamir, TAU’s VP in charge of international academic collaboration. “This collaboration includes hundreds of joint research projects as well as hundreds of German students who come to our campus each year. The joint center expands this collaboration in an important new direction and tightens our existing partnership with Goethe University Frankfurt, one of the leading universities in Germany. We hope that in the near future the two universities will expand collaboration to several other areas of common strength.”

Prof. Menachem Fisch and Prof. Christian Wiese (Photo: Tel Aviv University)

“What we are agreeing upon today is, as far as I am aware, unprecedented – at least in the humanities in Germany. It is not merely a formal cooperation between a German and an Israeli university, but rather the development of a highly visible, joint institutionalized international research center.” Prof. Enrico Schleiff

Even Closer Cooperation

Prof. Menachem Fisch, who heads the initiative at TAU says, “I am thrilled to be part of the establishment of a unique, first-of-its-kind center for the study of the monotheistic faiths and their mutual development. This is a worthy initiative, and one more building block in the academic collaboration between the two countries.”

Prof. Enrico Schleiff, President of Goethe University remarked at the initial signing of the agreement in December 2021: ”What we are agreeing upon today is, as far as I am aware, unprecedented – at least in the humanities in Germany. It is not merely a formal cooperation between a German and an Israeli university, but rather the development of a highly visible, joint institutionalized international research center.”

“The center is cross-departmental on both sides and working in an area of study that is most relevant to the German and the Israeli society alike: the history of and the present challenges in religious diversity, difference and conflict in pluralistic societies. It will focus on questions regarding inter-religious dialogue, religious fundamentalism and conflict, but also on the rich cultural heritage and the potential inherent in religious traditions. This center is the start of an even closer cooperation.”

Prof. Christian Wiese, who leads the initiative at Goethe University concludes, “In the framework of German-Israeli academic relations and the close connection between the cities of Frankfurt and Tel Aviv, we’re creating something very special here – an international research hub in the field of interreligious studies that looks at topics both from historical and contemporary perspectives that challenge both of our societies, German and Israeli, each in different ways.”

Featured image:

Prof. Ariel Porat, President of Tel Aviv University and Prof. Enrico Schleiff, the President of Goethe University (photo: Tel Aviv University)

Tel Aviv University Establishes Multidisciplinary Center for Research of Autoimmune Diseases

Written by AUFTAU on 18 December 2022. Posted in Newsroom.

Tel Aviv University has established the Colton Center, Israel’s first multidisciplinary center for the study of autoimmune diseases – chronic conditions involving an abnormal response of the immune system within body tissues. The Center will collaborate with Israel’s medical centers and health services including HMO’s and Hospitals as well as selected scientists from other academic institutions to enable big data analytics of medical information and biological samples from patients with autoimmune diseases and promote understanding of the causes of morbidity and recurrent flareups and possible early diagnostics and treatments.

The TAU research approach will be unique in its nature fundamentally being based on big data analytics that will direct any traditional scientific wet lab work. The intent of the center would be to grant research funding to multidisciplinary groups of scientists including computer science, engineering, biology, statistics, mathematics, psychology, and more. The different research programs will be managed based on agreed upon milestones with the ability to reach substantial sums upon success. In addition to its multidisciplinary clinical research, the new Center will encourage experimental and theoretical studies in immunology and conduct workshops and conferences jointly with the three other Colton Centers.

Goal: Finding a Cure for Autoimmune Diseases

The Center’s establishment was enabled by a generous donation of $10 million from TAU Governors Judith and Stewart Colton. It is the fourth research center founded by the Colton family to address autoimmune diseases, joining three centers already operating in the USA – at Yale University, the University of Pennsylvania, and NYU.

“Stewart and Judith Colton, renowned Jewish philanthropists and dear friends of TAU, have set themselves a goal,” explains Prof. Ariel Porat, President of TAU. This goal is “to develop drugs and treatments for autoimmune diseases. For this purpose, they have established dedicated centers at three leading American universities, and now decided to extend this activity to TAU.”

“This donation is following many years of active contribution by the Colton Foundation to TAU’s innovation and entrepreneurships in wide range of disciplines. We are proud to belong to this elite group of universities, and together with them and the Colton family, we will strive to find a cure for autoimmune diseases.”

“Even though autoimmune diseases have been known to science since the beginning of the 20th century, we still don’t have adequate tools for prevention, treatment, or prediction of morbidity and recurrent flareups.” Mr. Stewart Colton

Tel Aviv University

In Need of Adequate Tools

Mr. Stewart Colton comments: “We believe the Consortium created by the four universities will multiply the opportunities for advancing the chances for successful research. We have worked with TAU for almost 40 years and recognize the unique talent and dedication brought to innovative science. It is a terrible disease that deserves more attention.”

“I am particularly proud that Prof. Uri Nevo from the Department of Biomedical Engineering, who was one of the Colton Fellow graduates, was appointed to be the Chair of the Center’s Steering Committee.”

“The category of autoimmune diseases covers over 100 diseases, with relatively familiar examples including lupus, multiple sclerosis (MS), psoriasis, and Crohn’s disease. Autoimmune diseases are defined as diseases in which the immune system, instead of pathogens such as viruses and bacteria, or cells infected with these pathogens, attack the body’s healthy tissues. Even though autoimmune diseases have been known to science since the beginning of the 20th century, we still don’t have adequate tools for prevention, treatment, or prediction of morbidity and recurrent flareups.”

“The new Colton Center represents the best of basic and translational research – a true collaboration between researchers and clinicians to explore the optimal avenues for deciphering the mechanisms and therapy for autoimmune diseases.” Prof. Karen Avraham

True Collaboration Between Researchers and Clinicians

Prof. Karen Avraham, Dean of TAU’s Sackler Faculty of Medicine adds: “the new Colton Center represents the best of basic and translational research – a true collaboration between researchers and clinicians to explore the optimal avenues for deciphering the mechanisms and therapy for autoimmune diseases.”

“We will start our research carefully and modestly, hoping that from the focused study we will learn about the basic principles underlying autoimmune diseases, and eventually impact the understanding of many of these diseases, and benefit vast numbers of patients.” Prof. Uri Nevo

Aim to Benefit Vast Numbers of Patients

Prof. Uri Nevo from the Department of Biomedical Engineering, Chair of the Center’s Steering Committee, explains that the Center’s purpose is to promote the study and understanding of autoimmune diseases in order to improve their prevention and treatment. The first goal, he says, is to obtain measurable results, identify early signs and develop predictive algorithms for both initial onset and recurrent flare-ups. Eventually, studies may provide explanations, and possibly even discover the cause.

Other goals are to define practical recommendations for preventing onset and recurrence or reducing severity, and acquire new insights about disease mechanisms, enabling the development of new treatment strategies in the future.

Prof. Nevo: “Due to the complexity of the immune system, and the difficulty in measuring the interaction between the immune system and tissues in the body, we face some tough challenges. We do not understand the biological mechanism that drives many autoimmune diseases, or how they are connected with genetic and environmental risk factors. As a result, very few specific medications are on offer, and in many cases the disease becomes chronic.

“One of our main objectives is to establish research collaborations with various players: the medical institutions affiliated with TAU, the health services, and representatives of NPOs addressing the various diseases. Our intention is to sample their data and utilize the vast knowledge they have accumulated. The data will enable computerized analysis of samples taken from autoimmune patients in Israel, to help us understand the causes for the onset and recurrent flareups of these diseases.”

To choose the focus of its research for the next few years, the Colton Center is presently sending out a dedicated survey to thousands of clinicians and researchers in Israel. “We want to hear the opinions of doctors and experts, in order to focus on a limited number of diseases,” says Prof. Nevo. “We will start our research carefully and modestly, hoping that from the focused study we will learn about the basic principles underlying autoimmune diseases, and eventually impact the understanding of many of these diseases, and benefit vast numbers of patients.”

Featured image: Mr. and Mrs. Colton

Breakthrough in the Field of Controlled Drug Delivery

Written by AUFTAU on 16 December 2022. Posted in Newsroom.

In a world first, researchers found a way to control the encapsulation and release of molecules by exposure to UV light. The technology will advance the development of controlled release delivery systems for drugs and biomaterials.

Efficient encapsulation of molecules is considered a major technological challenge. The new technology, which allows for efficient encapsulation and high loading capacity of molecules, might address this need. The researchers estimate that the technology will lead to further development of delivery systems for controlled release of biomolecules and drugs in the body by external stimuli, using light.

Inspired by Measles

The research was led by PhD student Itai Katzir and supervised by Dr. Ayala Lampel from Shmunis School of Biomedicine and Cancer Research at The George S. Wise Faculty of Life Sciences at Tel Aviv University The study was published in the prestigious journal “Advanced Materials”.

The researchers explain that the new technology is inspired by viral compartments formed by the measles virus. Following infection of the host cell, the virus forms compartments that host all the reactions involved in the formation of new viral particles, a process which gives these compartments their name: viral factories. Recent studies show that these viral factories are in fact dynamic and liquid-like structures that are formed inside the host cell through a process called liquid-liquid phase separation.

Inspired by the viral protein, which is responsible for the formation of these factories, the researchers designed a “peptide” (= a short minimalistic protein) which forms compartments that resemble viral factories for encapsulation of biomolecules.

In addition, the researchers incorporated a unique element to the peptide sequence that enables a control of the encapsulation and release of molecules by irradiating the compartments using UV light.

“This technology opens opportunities for biomedical and biotechnological applications including encapsulation, delivery and release of drugs, protein, antibodies or other therapeutic molecules.” Dr. Ayala Lampel

Opens Opportunities for Biomedical and Biotechnological Applications

“Our goal was to engineer liquid-like compartments from a complex of peptide and RNA molecules that will enable efficient encapsulation of various biomolecules while keeping their native structure,” explains Dr. Lampel.

“The designed peptide and RNA form liquid-like compartments that resemble viral factories. We further developed these compartments to be stimuli-responsive by incorporating a protecting group to the peptide sequence that is cleaved following UV irradiation. The peptide with the photocleavable protecting group forms compartments with RNA, that have higher encapsulation efficiency for various molecules compared to compartments without the protecting group. We showed that by exposing the compartments to UV light and releasing the protecting group, we can control the release of encapsulated biomolecules.”

“Another unique property of this system is the high permeability and loading capacity of the encapsulated molecules, which is limited in part of the current technologies,” adds Dr. Lampel. “Thus, this technology opens opportunities for biomedical and biotechnological applications including encapsulation, delivery and release of drugs, protein, antibodies or other therapeutic molecules.”

Featured image: Dr. Ayala Lampel from TAU’s Shmunis School of Biomedicine and Cancer Research

Men Engage in “Chivalrous Sexism” when Donating to Women in Need

Written by AUFTAU on 15 December 2022. Posted in Newsroom.

A new study by Tel Aviv and Ben-Gurion Universities reveals a phenomenon of “chivalrous sexism” towards women in need. According to the study, about 2 out of 3 men (62%) would be willing to help a woman in distress whose house burned down – but fewer men (45%) would donate money to a woman whose business burned down. On the other hand, when the researchers examined the willingness of men to donate to other men, the trend that emerged was the opposite – according to which most men preferred to donate to men whose business was burned thus maintaining the male hegemony.

The researchers explain the differences by the fact that men tend to help women out of ‘chivalrous sexism’: helping a ‘damsel in distress’ is part of a men’s gender role, which is why a man will open the door for a woman or pull over to help her change a flat tire. But this help depends on the context: men help women if it does not challenge the male hegemony, in other words, if their help will empower women, then men will be less willing to help them.

The new study was conducted by Prof. Danit Ein-Gar from the Coller School of Management at Tel-Aviv University in collaboration with Dr. Orli Barkat, a post-doctoral student at Princeton University, and Prof. Tahila Kogot from Ben-Gurion University. The results of the study were published in the prestigious journal Group Processes & Intergroup Relations.

“When men were asked to donate, some of them found it easier to donate to a woman in her domestic, needy, and weak place than to a woman raising funds to rebuild her business.” Prof. Danit Ein-Gar

The Limitation of Male ’Chivalry’

According to Prof. Ein-Gar, 566 men and women from the USA participated in an online experiment. A cash prize of 10 dollars was drawn among the participants in the experiment, and the participants were asked to answer whether they would like to donate this amount to a man whose house burned down, to a woman whose house burned down, to a man whose business burned down, or to a woman whose business burned down.

Beyond the disparity in willingness to help women whose business burned down, compared to those whose house burned down, the findings also show that men donated an average amount of $4 (almost half of the winning amount) to a woman whose house burned down, compared to only $2.48 to a woman whose business house burned down.

The findings were replicated in another experiment conducted among management students at Tel Aviv University.

Prof. Danit Ein-Gar from the Coller School of Management at Tel-Aviv University

“We presented the participants with two identical requests for help from two individuals in need, a man and a woman, whose home or business caught fire,” explains Prof. Ein-Gar. “We found that the biggest differences, both in the actual willingness to donate and the donation amount, were when male subjects had to choose between helping a woman’s home and helping a woman’s business.”

“It should be noted that we did not present the fund request as a financial investment but rather as a donation: a fire raged in the area and consumed houses and shops, and now those in need are asking for help to rebuild their lives. When men were asked to donate, some of them found it easier to donate to a woman in her domestic, needy, and weak place than to a woman raising funds to rebuild her business”.

Prof. Ein-Gar explains that the new research reveals the boundaries of male ’chivalry’ – and these boundaries are set by men’s hegemony in the business world. That is, gentlemanliness reaches up to the point where it does not threaten their dominant status. A similar effect was not found when men were asked to donate to another man whose business burned down, compared to a man whose house burned down. This means that men do not donate less to businesses due to some business threat, but only donate less to women’s businesses.

Plastic Additives Harm Corals’ Reproductive Processes

Written by AUFTAU on 12 December 2022. Posted in Newsroom.

A new study by Tel Aviv University and the Interuniversity Institute for Marine Sciences in Eilat examined the effect of plastic additives on the reproductive process and larvae development of corals and other organisms commonly found in the coral reef of Eilat.

Plastic additives are chemicals that are added to plastic products during manufacturing, and many of them are known to be endocrine disrupting compounds. The current study shows that these chemicals can have species-specific effects that may damage the population structure and biodiversity of coral reefs.

The study was led by Ph.D. student Gal Vered of the Interuniversity Institute for Marine Sciences in Eilat and Tel Aviv University, and Prof. Noa Shenkar of Tel Aviv University’s School of Zoology in the George S. Wise Faculty of Life Sciences and the Steinhardt Museum of Natural History. The study was published in the prestigious journal Environmental Pollution.

The researchers focused on four organisms: a stony coral, a soft coral, a fire coral, and a solitary ascidian. These organisms play an important role in the ecology of tropical coral reefs, and damage to their reproduction and development may affect the structure of the reef community.

In addition, the researchers examined four chemical additives that are widely used in plastic products, and which have been found in seawater in tropical areas inhabited by coral reefs. Two of these were phthalate chemicals, which are used to soften and increase the flexibility of different types of plastic and can be found in a wide variety of consumer products such as food packaging, toys, medical devices, and adhesives. The others were 4-nonylphenol a stabilizer used in plastic packaging and as an additive in cleaning agents, and bisphenol A found in polycarbonate plastic that is used for food and beverage packaging, baby bottles, boxes, and more. The European Chemicals Agency has classified bisphenol A as a substance that may cause damage to human fertility, based on evidence found in laboratory animals.

“To better understand the impact of plastic additives on this endangered ecosystem, we suggest developing better methods for measuring the actual concentrations within the tissues of the organisms to produce relevant risk assessments.” Prof. Noa Shenkar

Selective Effect on Different Species

“Plastic additives are chemical additives that are incorporated into plastic products during the manufacturing process,” explains Gal Vered. “These substances reach marine environments through plastic waste and wastewater. Some of them are known to activate or suppress hormonal processes and can therefore disrupt biological systems. However, their effects on organisms in coral reefs have hardly been studied.”

“The structure of the coral reef population depends on the success of the reproduction, development and settlement of corals and other reef organisms. Interference with their hormonal systems may affect the chances of success of these processes, and an uneven effect on the different species may lead to a change in the community’s structure and damage to the entire system.”

The researchers conducted a series of exposure experiments in which the effects of the plastic additives were tested at environmentally relevant concentrations in seawater, and at higher laboratory concentrations. The parameters measured were fertilization, larvae development, larvae survival, and larvae settlement and metamorphoses.

The environmentally relevant concentration of 4-nonylphenol was found to inhibit larvae settlement in the soft coral, while a high concentration of the same compound damaged the fertilization, development, and settlement of all the studied organisms. The higher laboratory concentration of one of the studied phthalate chemicals damaged the settlement only of the stony coral larvae, and not of the other organisms’ reproductive products. These findings add to the accumulating evidence that plastic pollution has a selective effect on different species.

According to Prof. Shenkar, their findings “demonstrate plastic additives’ negative and selective effects on the development and reproduction of coral reef organisms. The environmentally relevant concentrations used in our experiments were concentrations found in seawater; alarmingly, some had deleterious effects on organisms’ reproduction. Nevertheless, concentration within organisms’ tissues may reach higher levels as these compounds can potentially bioaccumulate.”

“To better understand the impact of plastic additives on this endangered ecosystem, we suggest developing better methods for measuring the actual concentrations within the tissues of the organisms to produce relevant risk assessments.”

“Most of the coral reefs in the world are found in developing countries where the human population is expanding rapidly, and waste management is lacking. Steps towards preventing plastic waste from reaching the environment include proper local waste management that reduces transportation of waste, and sustainable consumption of products regulated for additives.” Gal Vered

The Importance of Proper Waste Management

“Climate change, ocean acidification, and ongoing anthropogenic stressors place coral reefs at existential risk,” says Gal Vered. Furthermore, she notes that, “most of the coral reefs in the world are found in developing countries where the human population is expanding rapidly, and waste management is lacking. Steps towards preventing plastic waste from reaching the environment include proper local waste management that reduces transportation of waste, and sustainable consumption of products regulated for additives.”

“We emphasize the importance of proper waste management that will reduce the presence of plastic waste from reaching the marine environment, as well as the need for methods to measure the concentration of chemicals inside the bodies of organisms, in order to assess the possible risk to their reproductive and developmental processes,” the researchers conclude.

Featured image: Prof. Noa Shenkar (photo: Hadas Zion)

Sir Frank Lowy Donates $18M USD to Tel Aviv University’s International School

Written by AUFTAU on 12 December 2022. Posted in Newsroom.

Sir Frank Lowy is donating $18M USD (65M NIS) to Tel Aviv University to expand the activities of the International School, to be renamed ‘THE LOWY INTERNATIONAL SCHOOL Dedicated to the Memory of Shirley Lowy’ (the School honors Shirley Lowy, the late wife of Sir Frank). The official name change of TAU’s International School will take place on Tuesday, December 20, 2022.

Enabling Further Expansion

The donation will fund the construction of a building that will serve as the new home of the International School, as well as the launch of three key activities at the International School:

The Lowy Scholarship Fund supporting outstanding international students at stages of their academic studies, including research students
The Lowy Distinguished Guest Professors Fund financing visits of leading scholars from abroad
The development of new international and local programs and initiatives

Sir Frank’s generous gift will also enable TAU to expand, enrich and diversify the School’s student body as well as its study programs. TAU already offers more than 20 English-language academic programs including a joint Liberal Arts bachelor’s degree with Columbia University, a new International BA in Management and Liberal Arts, and an online MBA program – the first of its kind in Israel.

Over 2,000 students from over 100 countries come to TAU every year, and there are more than 30,000 international student alumni worldwide. The School has experienced significant recent growth and now serves as the hub for all international activities on campus, including study programs, research partnerships, student exchanges, visits of scholars from abroad, and conferences.

The Lowy International School is central to TAU’s international strategy, aiming for several goals: enhancing international collaboration through research ties with leading institutions, attracting students from across the globe, and providing Israeli students with the tools they need to prosper in today’s globalized era. To date, the broad network of partners developed by TAU comprises over 280 institutions in 46 countries, including universities in the Gulf states and Morocco (a new and rapidly growing collaboration), Ivy League universities in the USA, and leading academic institutions in Europe and Asia.

Strengthening Ties between Israel and the World

“I have always been a Zionist,” says Sir Frank Lowy, “and now I am excited for this extension of my warm friendship with Tel Aviv University – intended to bolster TAU and Israel’s relations with leading partners in academia and industry around the world. With this gift, I hope to enhance the important connection between the State of Israel and Diaspora Jewry, and to encourage academic excellence by bringing the best researchers and students from all over the world to Israel.”

“My family and I know that my dear wife Shirley’s memory will forever live on at TAU, and this makes us very proud. Shirley believed in education, and in her 40s fulfilled a childhood dream and completed an academic degree. This tribute to my wife combines all the things that were most important to her – education, the state of Israel, and empowering the new generations. The gift in her memory will benefit students and scholars in many ways, and for years to come. I know that Shirley would be happy and honored to see that her legacy is commemorated in this way.”

Prof. Ariel Porat, President of Tel Aviv University: “Sir Frank Lowy’s leadership and philanthropic activity have for decades generated significant changes in communities in Israel, Australia, and worldwide. This new gift will further enhance his impact, strengthen the ties between Israel and the world, and extend the reach of Israeli academia.”

“It is a great privilege for us at Tel Aviv University to regard Sir Frank as a close and steadfast friend. The fact that he has seen fit to entrust us with the legacy of his beloved wife Shirley, is a great honor for us.”

TAU Vice President International Prof. Milette Shamir: “We are immensely grateful for Sir Frank Lowy’s gift. It is a great honor for us to house THE LOWY INTERNATIONAL SCHOOL Dedicated to the Memory of Shirley Lowy. This generous donation will allow us to significantly bolster the University’s international standing, attract hundreds of excellent international researchers and students, and strengthen TAU’s ties with communities around the world. This gift brings about an enormous transformation when it comes to TAU’s global impact.”

A festive ceremony celebrating the important gift will take place in December in the presence of Sir Frank and his family.

About Sir Frank Lowy

Sir Frank Lowy served for many years as the owner and Chairman of Westfield Corporation, a global real estate and shopping center conglomerate. He has been a steadfast friend of TAU for more than 20 years, has received an Honorary Doctorate from TAU, and serves as a TAU Governor. His generous contributions to TAU include support for the Institute for National Security Studies (INSS), the Center for Combating Pandemics, and research in the field of nanotechnology.

As part of his broad philanthropic activities Sir Frank provides support for the Jewish community in Australia and Israel and donates generously to a range of causes in the spheres of education, security, health, sports, and charity. He has held various leadership roles in Jewish organizations, including President of Keren HaYesod in Australia – United Israel Appeal, and Leading Member of the Jewish Communal Appeal (JCA) in Australia.

Sir Frank was born in Slovakia, managed to escape before the Holocaust, lived in Budapest during the Holocaust, then moved to the USA. He moved back and forth between the UK and Israel, even taking part in the War of Independence as a Golani soldier, before finally settling in Australia. As an ardent Zionist, he recently fulfilled a dream of many years, and once again made Aliyah to Israel.

Featured image: Prof. Ariel Porat, President of Tel Aviv University (to the left) and Sir Frank Lowy

Common Medications May Reduce Risk of Metastases after Colon and Rectal Cancer

Written by AUFTAU on 9 December 2022. Posted in Newsroom.

Although surgery to remove primary tumors is the mainstay of all cancer treatments, the risk of metastases after tumor removal is estimated at 35% among colon cancer patients, with higher risk in patients with more advance stages of the disease. However, a short, simple, and safe drug treatment developed at Tel Aviv University reduced the risk of the spread of cancer metastases after surgery to remove the primary tumor – according to the first clinical study of its kind conducted among 34 colon cancer patients operated on at Sheba Tel Hashomer Medical Center.

The research was led by Prof. Shamgar Ben-Eliyahu of TAU’s Sagol School of Neuroscience and School of Psychological Sciences at the Gershon H. Gordon Faculty of Social Sciences and Prof. Oded Zamora of TAU’s Sackler Faculty of Medicine, and its results were published in the European Journal of Surgical Oncology. At the same time, an overview of the theory and principles underlying the research was published in Nature Review Cancer.

“The stress during the waiting period for surgery, the stress and inflammation reactions that the body produces during the surgery itself and the physical recovery period, and finally the following anxiety of cancer recurring – all have an adverse effect on the body’s ability to fight metastatic processes,” explains Prof. Ben-Eliyahu. “These mental and physiological conditions create stress-inflammatory responses, which cause ample release of hormones from the prostaglandin and catecholamine families. These hormones suppress anti-metastatic immune activity, and thus encourage the development of metastases.”

“In addition, these hormones directly help the cancer cells that remain in the body even after surgery: due to exposure to these hormones, the cancerous tissue becomes more aggressive and metastatic. The good news is that we know how to treat both stress and inflammation using off-the-shelf medications.”

“This is a short, cheap drug treatment with no significant side effects. We deliberately sought the safest and cheapest drugs capable of lowering the body’s stress-inflammatory response to surgery, in order to save lives.” Prof. Shamgar Ben-Eliyahu

Significant and Encouraging Results

The researchers from Tel Aviv University gave 34 colon cancer patients two safe drugs that are available in every pharmacy: propranolol (Darlin), used to lower blood pressure and reduce anxiety, and etodolac (Etopan), used to prevent pain and inflammation.

Sixteen randomly chosen patients took the medication for 20 days – from five days before to two weeks after surgery at the Sheba Medical Center. The other 18 patients received placebo drugs (control group). Five years later, nine of the 18 patients who received the placebo (50%) developed cancer metastases, compared to two of the 16 patients who took Darlin and Etofen (12.5%).

“Although at five years after the operation, the statistical significance is clear, we need to conduct larger clinical studies,” says Prof. Ben-Eliyahu. “Our treatment reduced markers of metastasis in the tumor tissue and reduced the chances of cancer recurrence. This is a short, cheap drug treatment with no significant side effects. We deliberately sought the safest and cheapest drugs capable of lowering the body’s stress-inflammatory response to surgery, in order to save lives.”

“It sounds too good to be true, but similar results in breast cancer tissue were obtained in a study we conducted in 2017. Due to the small number of subjects in both studies, it is impossible to accurately estimate the magnitude of the beneficial effect, but the effects are statistically significant, meaning that they are not accidental.”

“We seek to save lives without financial gain, and we have received financial support from several Israeli and international sources, but these are insufficient for large clinical studies.” Prof. Shamgar Ben-Eliyahu

Saving Lives Without Financial Gain

According to Prof. Ben-Eliyahu, part of the medical establishment distrusts the effects of stress-inflammatory reactions, particularly those resulting from psychological factors such as waiting for surgery or fear of the disease spreading. Another problem concerns the financing of clinical studies.

“One should bear in mind that the pharmaceutical companies have no financial incentive to support such studies. Our medicines are not patented; they are safe, cheap, and administered in a short treatment lasting just a few days. The drug companies look for patents on expensive drugs and prefer that the patient be dependent on the drug for the rest of their life.”

“Unfortunately, the major science foundations in Israel do not fund clinical research on drugs, assuming that the drug companies will fund them. We seek to save lives without financial gain, and we have received financial support from several Israeli and international sources, but these are insufficient for large clinical studies. I hope that funding will be found for a large-scale clinical study that we have now embarked on, with the intention of recruiting hundreds of colon and rectal cancer patients in Israel, because without such research – we will not be able to convince the medical establishment of the treatment’s effectiveness.”

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About Sir Frank Lowy

Existing drugs to prevent anxiety, stress reactions and inflammation reduced the risk of the spread of cancer metastases after surgery to remove a colon tumor by tens of percent.

Significant and Encouraging Results

Saving Lives Without Financial Gain

Victoria

New South Wales

Western Australia