Newsroom – Page 4 – Australian Friends of Tel Aviv University

Can Parkinson’s Treatment be Enhanced by AI Tech?

Written by AUFTAU on 1 September 2024. Posted in Newsroom.

Researchers at TAU’s Faculty of Medical & Health Sciences invited the international community of machine learning researchers to participate in a contest devised to advance their study and assist neurologists: developing a machine learning model to support a wearable sensor for continuous, automated monitoring and quantification of FOG (freezing of gate) episodes in people with Parkinson’s disease. Close to 25,000 solutions were submitted, and the best algorithms were incorporated into the novel technology.

The study was led by Prof. Jeff Hausdorff from the Department of Physical Therapy at the Faculty of Medical & Health Sciences and the Sagol School of Neuroscience at Tel Aviv University, and the Center for the Study of Movement, Cognition, and Mobility at the Tel Aviv Medical Center, together with Amit Salomon and Eran Gazit from the Tel Aviv Medical Center. Other investigators included researchers from Belgium, France, and Harvard University. The paper was published in Nature Communications and featured in the Editors’ Highlights.

Prof. Hausdorff, an expert in the fields of gait, aging, and Parkinson’s disease, explains: “FOG is a debilitating and so far unexplained phenomenon, affecting 38-65% of Parkinson’s sufferers. A FOG episode can last from a few seconds to more than a minute, during which the patient’s feet are suddenly ‘glued’ to the floor, and the person cannot begin or continue walking. FOG can seriously impair the mobility, independence, and quality of life of people with Parkinson’s disease, causing great frustration, and frequently leading to falls and injuries”.

Amit Salomon adds: “Today the diagnosis and tracking of FOG are usually based on self-report questionnaires and visual observation by clinicians, as well as frame-by-frame analysis of videos of patients in motion. This last method, currently the prevailing gold standard, is reliable and accurate. Still, it has some serious drawbacks: it is time-consuming, requires the involvement of at least two experts, and is impracticable for long-term monitoring in the home and daily living environment. Researchers worldwide are trying to use wearable sensors to track and quantify patients’ daily functioning. So far, however, successful trials have all relied on a very small number of subjects”.

TAU’s AI Challenge Advances FOG Tracking

In the current study, the researchers collected data from several existing studies, relating to over 100 patients and about 5,000 FOG episodes. All data were uploaded to the Kaggle platform, a Google company that conducts international machine learning competitions. Members of the worldwide machine learning community were invited to develop models that would be incorporated into wearable sensors to quantify various FOG parameters (e.g. duration, frequency, and severity of episodes). A prize of $100,000, funded by Kaggle and the Michael J. Fox Foundation for Parkinson’s Research, was offered for the best solutions. 1,379 groups from 83 countries rose to the challenge, ultimately submitting a total of 24,862 solutions. The results of the best models were very close to those obtained through the video analysis method, and significantly better than previous experiments relying on a single wearable sensor.

Moreover, the models led to a discovery: an interesting relationship between FOG frequency and the time of day. Co-author Eran Gazit notes: “We observed, for the first time, a recurring daily pattern, with peaks of FOG episodes at certain hours of the day, that may be associated with clinical phenomena such as fatigue, or effects of medications. These findings are significant for both clinical treatment and continued research about FOG”.

Prof. Hausdorff: “Wearable sensors supported by machine learning models can continuously monitor and quantify FOG episodes, as well as the patient’s general functioning in daily life. This gives the clinician an accurate picture of the patient’s condition at all times: has the illness improved or deteriorated? Does it respond to prescribed drugs? The informed clinician can respond promptly, while data collected through this technology can support the development of new treatments. In addition, our study demonstrates the power of machine learning contests in advancing medical research. The contest we initiated brought together capable, dynamic teams all over the world, who enjoyed a friendly atmosphere of learning and competition for a good cause. Rapid improvement was gained in the effective and precise quantification of FOG data. Moreover, the study laid the foundations for the next stage: long-term 24/7 FOG monitoring in the patient’s home and real-world environment”.

BOG 2024: The Selwyn-Cameron Laboratory Opens Doors

Written by AUFTAU on 29 August 2024. Posted in Newsroom.

The new neuro-engineering lab has the potential to revolutionize our understanding of the brain and create new possibilities for medical and technological advancements.

Tel Aviv University inaugurated the Selwyn-Cameron Laboratory for neuro-engineering during its 2024 international Board of Governors meeting. The Lab will serve as a dynamic hub that brings together young researchers from diverse disciplines, ranging from engineering and life sciences to psychology. Its inauguration was made possible by the support of the Selwyn and Cameron families from the Victorian chapter of Tel Aviv University’s Australian Friends Association. The project was co-ordinated in Australia by Rosie Potaznik who was then the President of the Victorian chapter.

Located in the ground-breaking Roman Abramovich Building for Nano and Quantum Science & Technology, the lab is headed by Prof. Yael Hanein, an electrical engineer and nanoscientist renowned for her work on artificial retinas. Hanein’s research focuses on restoring vision to people with age-related macular degeneration (AMD), by using electrodes that interact with the nervous system. The Lab was already awarded a prestigious 2.5 million euro grant from the European research community, demonstrating its excellence in the field.

“I am amazed by the devotion of the members of the Australian Friends to Tel Aviv University, and more generally, to Israel,” said TAU President Prof. Ariel Porat at the opening ceremony. The President spoke briefly about each of the donors and their history of philanthropy.

Eva Selwyn

The Selwyn family’s enduring legacy at Tel Aviv University spans over three decades, marked by their remarkable generosity and commitment to philanthropy in the realms of infertility treatment and engineering.

Following the passing of Ada and Alan Selwyn, their daughter Eva, a longstanding Governor, has admirably carried on their vision, steadfastly supporting the university through various initiatives and programs.

Amidst the challenges brought by the Covid pandemic, Eva demonstrated her unwavering support by bolstering the Walter Kastelan scholarship fund.

More recently, she has championed the funding for the Nano building laboratory under the leadership of Prof. Yael Hanein. Hanein’s research in artificial retinas deeply resonated with Eva. “This important project made me feel like I was making a significant difference to people’s lives in helping them to retain their sight,” she said, commenting on her gift.

When faced with the tragic events of October 7 and the ensuing war in Gaza, Eva reached out to inquire about further ways she could contribute. Her concern for the students at TAU impacted by the war led to a collaborative effort to provide substantial funding to PTSD clinics, aiding returning reservists and members of the public in recovering from the trauma they have suffered.

In the past, Eva has called to update her donations during times of need, reflecting her genuine commitment.

“We are immensely grateful for Eva’s unwavering support, recognizing and applauding not only her philanthropy but also her steadfast loyalty to the state of Israel,” said President Porat.

Australian Friends visiting the new Lab (Photo: TAU)

The Late Wallace S. Cameron

Passed away suddenly in February this year aged 79, Mr. Cameron is survived by his wife Joan and his three children.

Having come from humble beginnings, the late Mr. Cameron worked hard to improve himself through education. He graduated from Melbourne University with a Bachelor of Laws, Bachelor of Commerce, Master of Business Administration, and Master of Letters.

His early career was as a barrister practicing in Victoria. He subsequently developed a significant pathology company called Gribbles, which provided services primarily to general practitioners by setting up a large number of pathology laboratories to service their needs. Some of his colleagues described him as a visionary, particularly for his foresight in molecular biology research and his recruitment of star scientists to the company.

A zealous philanthropist, Wallace Cameron contributed to and supported the Jewish community in many ways. Sadly, Wallace did not get to see his latest project to its fruition, but his family carries on his commitment, knowing that this is what Wallace would have wanted.

The inauguration ceremony concluded with closing remarks from the Lab’s head, Prof. Yael Hanein. “Dear Australian Friends, I’m deeply grateful for your contribution to this endeavor. Your belief in our vision and your commitment to advancing scientific research is critical in allowing us to pursue new discoveries and innovations,” she said.

Building Bridges Through Cuisine

Written by Hilary on 21 August 2024. Posted in Newsroom.

Aliya Fastman, the founder and owner of Citrus&Salt cooking studio in Tel Aviv, is a California native who has made a significant impact on the city’s culinary landscape. A graduate of Tel Aviv University’s International MA in Conflict Resolution and Mediation, Fastman now calls Tel Aviv home, where she combines her love for cooking with her dedication to building connections between people through the shared experience of food.

In our interview, Aliya Fastman shares her journey and insights on how cuisine can serve as a powerful medium for promoting understanding and unity.

From Conflict Resolution to Culinary Diplomacy

I first came to Israel for a year abroad. After finishing school, I came back for the army, left again, then came back for my master’s degree. I’ve been here ever since.

I finished my master’s degree in Conflict Resolution and Mediation at TAU in 2016, and I thought I wanted to go into traditional diplomacy, but instead, I found myself, like many, needing to have a job. So I went into public relations in the high-tech sector, where I worked for several years. I really liked it, and it was a good learning experience.

But on nights and weekends, I started building a business called Citrus and Salt, which was originally intended to teach Israeli cooking and other local cuisines to tourists. It started out of my home, and then I got a bigger home, so I had more students. Now we’re actually on to our second brick-and-mortar studio.

At our current studio, we offer both cooking classes and different cultural events.

With fewer tourists now, we have started offering cuisines that locals are interested in. I am passionate about traveling to places like Thailand, India, and Italy to learn from chefs there, getting to know their culture through their kitchen and bringing those cuisines and flavors back to Israel.

In addition, we have an initiative that I hope to grow, which is cultural nights for cross-cultural awareness through food. Our first Indian night was sold out with a waiting list – it was with a family of Olim from Mumbai who shared their story. I’d love to replicate this with Ethiopian culture, Arab-Israeli culture, and more.

Connecting People Through Food

In a way, although I didn’t realize it in the beginning, what we do is very much diplomacy through food. Essentially, as we learned in our degree, whenever you gather people together in a shared activity, it helps them get to know each other and helps create good relations. There’s almost no activity that’s better for that than cooking.

Our business has brought together people from many countries, including Germany, Uruguay, Hong Kong, the United States, and South Africa. They cook together and share their stories.

Regarding Israel, which is my passion, our studio provides a safe and calm space for people who are visiting Israel and who have heard a lot about it, to ask me questions about the culture, the conflicts, the food, and everything in between.

I don’t think any questions, if they’re coming from a good place, are unpleasant. People want to be informed and understand more. This has allowed me to be a bit of an advocate for Israel through the kitchen.

Showcasing Israeli and Diaspora Cuisines

Our classic Israeli menu has falafel, hummus, perfectly puffy handmade pita, shakshuka, and smoked eggplant with tahini, and Israeli salad. It’s vegetarian-friendly and accommodating to a range of dietary needs.

We also offer Moroccan, Iraqi, and Yemenite dishes to introduce our visitors to diaspora cuisines.

Personally, I love North African Moroccan cuisine, like tagine and couscous. The way the spices simmer together is unlike anything I experienced in the United States.

During my year at TAU, I traveled to Morocco with friends from the program for a couple of weeks and we were able to dive more into the culture there.

Citizen’s Kitchen: Bringing Comfort to Soldiers and Families

From October 9, we opened a war kitchen out of our cooking studio, and have made over 65,000 meals since then, feeding soldiers, families of hostages, displaced people, and families of reservists. It’s very much a community initiative where people from around the world and local Israelis came together to cook.

We rely on donations from international volunteers and donors to fund Citizen’s Kitchen, and we also have a GoFundMe.

The initiative emerged during rocket fire, at a time of great trauma, so we started also offering some therapy and different Shabbat community events to help create a foundation for people, while also doing a public service.

As locals go back to work, we’re inviting groups from Europe and the United States to volunteer. We’re pushing forward with both the volunteer and the regular studio activities in tandem.

We’ve gotten a lot of praise for our food, with soldiers saying it’s the best food they’ve had. We believe that if we’re doing this, the food should be tasty and of good quality.

Our ethos is comfort through food.

In the beginning, we made a lot of schnitzel. Our chefs really put together a fabulous recipe with the chicken marinated in coconut milk and spices overnight.

Now we’ve been making a lot of sandwiches because we’ve been sending them to the North and in armored vehicles to soldiers in Gaza. We try to do really nice ones, such as freshly baked ciabatta rolls with teriyaki chicken and a crisp cabbage salad.

For families, we make dishes like stuffed onions and grape leaves, roast chicken, egg noodles with grilled vegetables and sesame seeds, fresh watermelon, baked food, and Israeli salad. Sometimes, we also send smoked eggplant with tahini, different cabbage salads, or meatballs in fresh tomato sauce.

More important than even the food is the fact that we’re here as an international community of Jews and allies, supporting the soldiers on the frontline and the survivors, saying that it’s not over.

Although a lot of kitchens have had to close, and we’re not at the same capacity we were, cooking just twice a week now, each meal counts and each partnership counts. We’re still cooking because they’re still fighting.

We’re also sending letters to soldiers from our international volunteers just to emphasize that we support them: “We have your back. You’re not alone in this.”

Looking Back on Studying at TAU

My degree taught me to communicate with different cultures, which is vital for my work even though it’s not formal diplomacy.

I loved the advanced mediation course—diving into it and doing the simulations really helped me.

It’s proved invaluable with some problematic situations and in dealing with students and volunteers of different cultural backgrounds.

Every culture has its particularities, and I need to be able to bring all students together around the table. For example, Americans love little spoons to taste what they’re making, while Israelis use their hands.

Being aware of cultural differences is almost more important than how the food tastes because that leaves people feeling understood and having a nice experience.

I also found it absolutely wonderful to be able to study from people who were instrumental in making history. Professor Daniel Reisner, for example, was involved in creating some of the laws and deals and offered us a refreshing perspective on them.

I’m a true believer in the fact that everything you do is a building block, whether it’s my waitressing after the army, or my job in PR.

This applies to my formal education as well—I didn’t know it would lead me here, but it’s definitely something that I needed, and I’m glad I did it.

I still have great friends from the course who stayed in Israel and we always speak about how it has helped us.

Connecting Education, Israel, and Global Advocacy

From my personal experience, I loved the education and the experience at TAU. It has been valuable for me and other alumni that I’ve spoken to.

I think that it’s very special to come and study in Israel and to be able to maintain connections here.

First and foremost, Jews need to be in a safe place. I think coming to strengthen the state here is very important. I also find great inspiration in Eylon Levy’s citizen spokesperson initiative to find people who are able to speak to Western audiences. Even if it doesn’t help the person you’re talking to, it might help the people on the sidelines.

The more well-educated, articulate, and well-informed internationals are in getting our message out there, to their communities, the better.

It does make a difference, and I believe there is hope for people who don’t necessarily have antisemitic beliefs, but simply follow the crowd.

Photos courtesy of Aliya Fastman and Citrus&Salt

The Reason Behind the Dancing Sunflowers

Written by Hilary on 21 August 2024. Posted in Newsroom.

As they grow, sunflowers “dance” to avoid blocking each other’s sunlight

Flowers have long fascinated scientists and nature enthusiasts alike, not just for their beauty, but also for their subtle, almost imperceptible movements. Over a century ago, Charles Darwin was the first to observe that plants, including flowers, exhibit a kind of cyclical movement as they grow. This movement, seen in both stems and roots, puzzled researchers: Was it just a byproduct of growth, or did it serve a crucial purpose?

A new study by Tel Aviv University, in collaboration with the University of Colorado, Boulder, discovered that plants that grow in dense environments, where each plant casts a shadow on its neighbor, find a collective solution with the help of random movements that help them find optimal growth directions. In this way, the study sheds light on the scientific enigma that has occupied researchers since Darwin, namely the functional role of these inherent movements called circumnutations.

The research was conducted under the leadership of Prof. Yasmine Meroz from the School of Plant Sciences and Food Security at the Wise Faculty of Life Sciences at Tel Aviv University, in collaboration with Prof. Orit Peleg from the University of Colorado Boulder in the USA. The research team included Dr. Chantal Nguyen (Boulder), Roni Kempinski and Imri Dromi (TAU). The research was published in the prestigious journal Physical Review X.

Do flowers have a sense of direction?

Prof. Meroz explains: “Previous studies have shown that if sunflowers are densely planted in a field where they shade each other they grow in a zigzag pattern – one forward and one back – so as not to be in each other’s shadow. This way they grow side by side to maximize illumination from the sun, therefore photosynthesis, on a collective level. Plants know how to distinguish between the shadow of a building and the green shadow of a leaf. If they sense the shadow of a building – they usually don’t change their growth direction, because they ‘know’ that will have no effect. But if they sense the shadow of a plant, they will grow in a direction away from the shadow”.

According to the researchers, Darwin was the first to recognize that all plants grow while exhibiting a kind of cyclical movement known as “circumnutation”, which is observed in both stems and roots. However, until today—except for a few cases, such as climbing plants that grow in large circular movements to find something to grab onto—it was unclear whether this was an artifact or a critical feature of growth. Why would a plant invest energy to grow in random directions?

In the current study, the researchers examined how sunflowers “know” to grow optimally—maximizing sunlight capture for the collective—and analyzed the growth dynamics of sunflowers in the laboratory, where they exhibit a zigzag pattern. Prof. Meroz and her team grew sunflowers in a high-density environment and photographed them during growth, taking pictures every few minutes. The photographs were then combined to create a time-lapse movie. By tracking the movement of each sunflower, the researchers observed that the flowers were “dancing” a lot.

Shake your Tail Petal

Prof. Meroz stated, “As part of our research, we conducted a physical analysis that captured the behavior of each sunflower within the collective, revealing that the sunflowers ‘dance’ to find the optimal angle, ensuring that each flower does not block the sunlight of its neighbor. We quantified this movement statistically and demonstrated through computer simulations that these random movements are used collectively to minimize shadowing. It was also surprising to find that the distribution of the sunflowers’ ‘steps’ was very wide, ranging over three orders of magnitude, from nearly zero displacements to movements of up to two centimeters every few minutes in various directions”.

In conclusion, Prof. Meroz adds: “The sunflower plant takes advantage of its ability to use both small, slow steps and large, fast ones to find the optimal arrangement for the collective. If the range of steps were smaller or larger, the arrangement would result in more mutual shading and less photosynthesis. It’s somewhat like a crowded dance party, where individuals move around to create more space: if they move too much, they’ll interfere with the other dancers, but if they move too little, the crowding problem won’t be solved, leaving one corner of the square overcrowded and the other empty. Sunflowers exhibit a similar communication dynamic—a combination of responding to the shade of neighboring plants and making random movements regardless of external stimuli”.

Want to Fall in Love? Step Outside in The Sun

Written by Hilary on 19 August 2024. Posted in Newsroom.

Any Tel Avivian will tell you that the perfect place for a first date is at the beach. Now, we have the science to support that claim. Researchers at Tel Aviv University have found that exposure to ultraviolet radiation from sunlight enhances romantic passion in humans. In the study, men and women were exposed to UVB (ultraviolet radiation type B) under controlled conditions, and the findings were unequivocal: increased levels of romantic passion in both genders.

Sun + Skin = Love

The study revealed that exposure to sunlight affects the regulation of the endocrine system responsible for the release of sexual hormones in humans. The discovery may lead to practical applications down the line, such as UVB treatments for sexual hormone disorders.

In animal models, the effect was dramatic: the females’ hormone levels rose significantly, enlarging their ovaries and prolonging their mating season; the attraction between males and females increased; and both were more willing to engage in sexual intercourse.

The researchers repeated the experiment on the animal model, this time removing from the skin a protein called p53, which identifies DNA damage and activates pigmentation during exposure to sunlight as protection against its adverse effects. The removal of the protein eliminated the effect of UVB exposure on the animals’ sexual behavior, convincing the researchers that exposure to radiation through the skin was the cause of the observed hormonal, physiological and behavioral changes, and that the protective system is also responsible for the regulation of sexuality.

Furless Humans and Sun Exposure

In the 32 human subjects of the study, all treated with UVB phototherapy at the Tel Aviv Sourasky (Ichilov) and Assuta Medical Centers, both genders exhibited a rise in romantic passion, and males also noted an increase in levels of aggression.

Similar results were found when the subjects were asked to avoid sunlight for two days, and then tan themselves for approximately 25 minutes. Blood tests revealed that exposure to sunlight resulted in a higher release of hormones like testosterone compared to one day before exposure. A rise in testosterone in males during the summer was also found in analyses of data from the Israeli health maintenance organizations Clalit and Maccabi Health Services.

Prof. Carmit Levy (on the left) & PhD student Roma Parikh.

The new discovery from TAU may lead to future practical applications, such as UVB treatments for sexual hormone disorders. The breakthrough opens up for further discoveries in basic science, “As humans, we have no fur, and our skin is thus directly exposed to sunlight. We are only beginning to understand what this exposure does to us, and the key roles it might play in various physiological and behavioral processes. It’s only the tip of the iceberg,” says Prof. Carmit Levy from the Department of Human Molecular Genetics and Biochemistry at the Sackler Faculty of Medicine.

The study was led by PhD student Roma Parikh and Ashchar Sorek from the laboratory of Prof. Levy. UVB phototherapy was administered to the subjects at the Tel Aviv Sourasky (Ichilov) and Assuta Medical Centers. The groundbreaking discovery was published as a cover story in the prestigious scientific journal Cell Reports.

Animals Experience War Stress Too

Written by Hilary on 18 August 2024. Posted in Newsroom.

TSU study examines the impact of the Israel-Hamas war on wildlife

A new study conducted at Tel Aviv University’s School of Zoology, Wise Faculty of Life Sciences and Steinhardt Museum of Natural History reveals that the Israel-Hamas war has had a severe impact on animals. The study, which focused on geckos, found that the sound of explosions from fired rockets induces stress and anxiety in these creatures, leading to a sharp increase in their metabolic rates — an energy cost that, if chronic, may be life-threatening. The researchers hypothesize that these stress responses characterize many other animals, especially those who live in the conflict zones in northern and southern Israel.

The study was led by a team of researchers from TAU’s School of Zoology and Steinhardt Museum of Natural History — Shahar Dubiner, Prof. Shai Meiri, and Prof. Eran Levin — in collaboration with Dr. Reut Vardi of the University of Oxford. The study was published in the journal Ecology.

Energy Changes in Wildlife

Prof. Shai Meiri explains: “The most tragic aspect of war is the loss of human life, among both soldiers and civilians. However, animals are also severely affected, both directly and indirectly, in ways that may threaten their survival. A few weeks before October 7, we began working on a long-term study to measure the rate of energy consumption of small ground geckos of the species Stenodactylus sthenodactylus. We obviously did not foresee the outbreak of the war, but unintentionally, we recorded the energy consumption of five geckos during the rocket barrages launched into Tel Aviv in the first month of the war”.

The study’s findings showed that at the sound of the bombings, the geckos’ metabolic rate jumped to double what it was when they were at rest. Their breathing became faster, and they clearly exhibited signs of stress. The experiment lasted up to four hours after the barrages, yet even within this timeframe the geckos did not calm down and return to their resting levels. Moreover, even after a month of continuous fighting, the geckos did not acclimate to the sound of the explosions — their stress response remained unchanged.

Left to right: Prof. Shai Meiri and Prof. Eran Levin.

Prof. Levin: “A state of stress is detrimental to both humans and animals. To compensate for the increase in oxygen consumption and depletion of energy reserves, animals need to eat more. Even if they manage to find food, in the process they expose themselves to predators and lose opportunities to reproduce. In a situation of ongoing conflict, such as the current reality in Gaza, the Gaza Envelope, and along the Israeli-Lebanese border, the metabolic cost can be significant and have a real impact on the energy reserves and activity periods of reptiles and other animals. This can exacerbate their conservation status, especially for species that are already endangered”.

The researchers note that the findings of this study are consistent with another experiment conducted during Operation Guardian of the Walls, in which they also observed a stress response in a small snake of the species Xerotyphlops syriacus.

Shahar Dubiner concludes: “Our research was conducted in a laboratory at Tel Aviv University and pertained to the reverberations of explosions from interceptions in the Tel Aviv area. However, given the unequivocal results showing symptoms of stress, we can infer that animals that are in the immediate conflict zones in the south and north of the country, where the intensity and frequency of fire are much higher, suffer from significantly more severe stress and anxiety symptoms that may endanger their lives”.

Turning Organic Waste to Tomorrow’s Fuel

Written by Hilary on 18 August 2024. Posted in Newsroom.

TAU’s new method turns raw wet waste into biofuels, potentially meeting a third of Israel’s marine fuel needs.

An innovative development by a team of Tel Aviv University researchers allows for converting the wet raw waste that we throw in the trash into liquid and solid biofuels, without the need to dry the waste. The researchers assess that at the national level, fuels produced from organic waste can, among other things, meet about a third of Israel’s marine fuel consumption.

The study was led by Prof. Alexander Golberg of Tel Aviv University’s Porter School of Environment and Earth Sciences and was published in the journal Energy Conversion and Management: X. The research was conducted by Ph.D. candidate Maya Mosseri in collaboration with engineer Michael Epstein, Prof. Michael Gozin of the School of Chemistry, and Prof. Avraham Kribus of the Fleischman Faculty of Engineering.

How Israel Handles Its Waste Crisis

Israel’s waste problem is escalating. In 2019, the country generated approximately 5.8 million tons of municipal waste, averaging about 1.76 kg per person per day — about 30 percent more than the European average. This figure increases every year by about 2.6 percent. Currently, about 80 percent of household waste in Israel ends up in landfills. Organic waste presents a significant challenge, harming the environment through greenhouse gas emissions, leachate formation, and the pollution of air, water, and soil, often accompanied by unpleasant odors.

The Research Team.

“Organic waste emits methane, which is a greenhouse gas, and also contaminates groundwater”, explains Prof. Golberg. “The treatment of waste is a critical issue. Landfill sites in Israel are reaching capacity, and despite the desire to reduce landfill to a minimum, we are forced to open new sites, because there is no other solution. The major advantage of our proposal is that we will reduce the need for so many landfill sites. Municipalities invest considerable funds on waste transportation and treatment, and this solution has the potential to significantly cut those expenses”.

To assess the potential of municipal waste in Israel, the researchers analyzed the results of a groundbreaking 2018 survey conducted by E. Elimelech et al. from the University of Haifa. The survey examined the composition of the garbage produced by 190 households in the city of Haifa over the course of a week. The findings revealed that measurable organic waste constitutes about 36.4 percent of food waste and about 16.4 percent of total household waste. The category of measured organic waste was further analyzed, showing that it comprised 67 percent fruits and vegetables, 14 percent breads, pastas and cereals, 8 percent eggs and dairy products, 5 percent by-products such as peels and skins, 3 percent meat, fish and poultry, 2 percent sweets and cookies, and 1percent soft drinks. In general this organic waste contains around 80% water.

Turning Trash into Treasure

“The results of this survey formed the basis for the waste model in our study,” says Prof. Golberg. “We built a continuous reactor — which will eventually be adaptable for solar energy usage — to heat the waste to 280 degrees Celsius, and we were able to significantly reduce the amount of water and oxygen in the biofuel. We found cost-effective catalysts that make it possible to control the ratio between the liquid and solid fuel products. Solid fuel can be used as biochar, effectively sequestering carbon dioxide for extended periods. The biochar can be burned in power plants like regular coal and liquid biofuels, and after upgrading, it can power planes, trucks, and ships”.

Using the representative model of the measured organic waste, the TAU researchers successfully produced liquid biofuel with a yield of up to 29.3 percent by weight and solid fuel with a yield of up to 40.7 percent based on dry raw material. This process is versatile and suitable for treating any wet organic waste or residue, for example, organic waste from food factories, institutional kitchens, and hospitals.

The researchers conclude: “The production of biofuels from organic waste components can significantly reduce the volume of municipal waste sent to landfills, thereby decreasing environmental pollution of soil, water, and air. Moreover, reducing landfilling will lower greenhouse gas emissions and decrease reliance on oil and coal. Converting waste into energy also offers a local solution for Israel’s energy independence and security”.

The researchers thank the chief scientist of the Israeli Ministry of Energy and the company Noga for their support of the research.

Can Smartwatches Prevent Pandemic Outbreaks?

Written by Hilary on 7 August 2024. Posted in Newsroom.

Researchers Discover How Smartwatches Can Stop Disease Spread by Early Detection

Researchers from the Department of Industrial Engineering at TAU’s Faculty of Engineering led a two-year study in which participants wore smartwatches that measured biomarkers and answered questions about their health every day. The results indicate that the wearable technology identified a change in key physiological parameters one to three whole days before the user felt the first symptom of the disease: a gap of 23 hours for COVID-19, 62 hours for group A streptococcus (GAS), and 73 hours for influenza.

The researchers: “Early diagnosis enabled by wearable technologies can be critical for inducing behavioral changes, such as reduced social contacts at an early stage, when the disease is most infectious. Potentially, this can prevent the spread of disease and even preempt global pandemics in the future”.

The study was led by Prof. Dan Yamin, an expert in epidemiology and infectious disease modeling and Head of the Lab for Digital Epidemiology and Health Analytics, and Prof. Erez Shmueli, Head of the Big Data Lab, both from TAU’s Department of Industrial Engineering. Other participants included: research students Shachar Snir and Matan Yechezkel from the Department of Industrial Engineering, Dr. Tal Patalon from the Kahn Sagol Maccabi Research and Innovation Center at Maccabi Healthcare Services and Yupeng Chen and Prof. Margaret Brandeau from the Department of Management Science and Engineering at Stanford University. The paper was published in Lancet Regional Health Europe.

Prof. Yamin: “Infectious diseases and pandemics pose a great threat to humanity, and we must harness our scientific and technological abilities to prevent them. Previous studies have shown that during the recent pandemic about 40% of all transmissions occurred about a day before the first symptoms appeared. In other words, the person transmitting the disease was unaware they were infected. In this study we checked whether wearable technologies could provide earlier diagnosis, to reduce contagion and prevent the spread of infectious diseases”.

Tracking Key Health Changes

During the two-year study, 4,795 Israelis over 18 years of age wore a smartwatch that continuously monitored key physiological parameters, focusing on pulse rate at a 15-second resolution and HRV (Heart Rate Variability). Prof. Yamin explains: “Pulse rate and HRV provide crucial information about the two most important systems in our body – the heart and the brain. Our brain constantly consumes energy, burning oxygen provided by the cardiovascular system, and consequently, any change in our activity or condition is immediately reflected in a change in HRV. When a person becomes ill, most of the focus goes to a single system – the immune system battling the disease, keeping the heart rate relatively steady, and reducing its variability, the HRV. In this way, changes in HRV indicate physical stress”.

In addition to wearing the smartwatches, participants answered a series of general questions about their condition every day: How do you feel physically? How do you feel mentally? Have you engaged in physical activity? Do you have any specific symptoms? Etc. In addition, they were provided with home test kits for three different diseases – COVID-19, influenza, and group A streptococcus – which they used at their discretion. Over two years, the researchers collected 800,000 questionnaires and this data was compared with parallel data from the smartwatch. Altogether, the data included 490 episodes of influenza, 2206 episodes of COVID-19, and 320 episodes of GAS.

Based on their abundant data, the researchers built special models that identified three critical points in time following exposure to an infectious disease. For instance, COVID-19: A. The first physiological anomaly in heart rate measures – 96 hours after exposure, an interval, which the researchers call the ‘digital incubation period’; B. The first symptom noticed by the person –130 hours after exposure, an interval commonly known as the ‘incubation period’; and C. Testing that ultimately diagnosed the disease – usually about 168 hours after exposure, called the ‘diagnostic decision period’. The period from exposure to digital diagnosis, namely the digital incubation period, was even shorter for influenza (24 hours) and GAS (60 hours).

Getting Ahead of the Curve?

Prof. Shmueli: “Early diagnosis is extremely important for preventing the spread of the disease. Moreover, we found that even when our subjects reported first symptoms, they tended to postpone testing for a while – 53 hours for COVID-19, 39 hours for influenza, and 38 hours for GAS. Consequently, for quite a long interval, from exposure to testing, they did not change their social behavior, spreading the disease to others. We found that on average, people performed the test and changed their behavior when the disease was already past its peak, and they were much less likely to infect others. The delay between digital diagnosis and testing – 64 hours in the case of COVID-19, 68 hours for influenza, and 58 hours for GAS – is thus extremely crucial”.

Prof. Yamin: “Our findings indicate that at the population level digital diagnosis can significantly reduce the spread of infectious diseases, by causing people to change their social behavior at a much earlier stage of the disease. This can even prevent the next pandemic – by bringing the basic reproduction number (R0value) to below 1.0, which means that every sick individual transmits the disease to less than one other person, and the disease soon dies out”.

The researchers add that early diagnosis is also critical for effective treatment. Specifically, for COVID-19, existing treatments are very effective only when given early on, preventing severe illness, hospitalization, and even death.

A Milestone in Stopping Pandemics

Prof. Yamin: “In an ERC-funded paper published in October 2019, shortly before the outbreak of the COVID-19 pandemic, I argued that infectious diseases pose the greatest threat of a global catastrophe. The threat is especially great in the modern world, with people traveling all over the globe and potentially spreading new diseases. However, modern technology can help us combat this danger and devise more effective public health strategies. Our new method, using wearable sensors for early detection of contagious disease can potentially reduce the threat of epidemics to a minimum. Smartwatches are a relatively new technology, with enormous potential, and novel, even more sensitive and accurate wearable sensors are constantly being developed. Ultimately, this can be a high-impact tool for preempting future pandemics”.

TAU Researchers Win the Prestigious Rousseeuw Prize for Statistics

Written by Hilary on 7 August 2024. Posted in Newsroom.

The King Baudouin Foundation has awarded the prestigious Rousseeuw Prize for Statistics to Prof. Yoav Benjamini, Prof. Daniel Yekutieli, and Prof. Ruth Heller from the Department of Statistics and Operations Research at Tel Aviv University for their pioneering work on False Discovery Rate (FDR). The biennial $1m prize, inaugurated in 2022 and awarded in even years, honors outstanding innovations in statistical research that profoundly impact society.

The Prize was awarded to this year’s laureates for work that enables scanning large numbers of experimental results and selecting real discoveries while limiting the number of false discoveries. In their groundbreaking paper, Prof. Yoav Benjamini and the late Prof. Yosef Hochberg first presented the FDR criterion, expressed it mathematically, and proposed a method for identifying a maximum number of discoveries while maintaining a desirable FDR. At the time, this paper conflicted with widely accepted criteria, and consequently, its publication was delayed for years. Today, however, it is one of the most highly cited papers in the scientific world.

Prof. Benjamini was joined by his students Profs. Yekutieli and Heller who continued in his footsteps both together and separately, adding further innovations to the theory of FDR. Their work has enabled the extension of the Benjamini-Hochberg method’s uses beyond the original paper, applying it to challenges in genomics and neuroscience and proposing methods for assessing the reproducibility of scientific findings.

Prof. Yoav Benjamini: “The concept of FDR was born from a need in medical research, specifically studies examining large numbers of success parameters to evaluate new treatments. However, in statistics, a new approach established in one field of research can also impact other areas. Today FDR methods are applied in a wide variety of fields, such as genomics – where researchers investigate tens of thousands of genetic indicators for certain diseases; neuroscience – where studies look for parts of the brain activated by specific tasks, such as face recognition; and also agriculture, economics, behavioral sciences, astronomy and more. All these fields share a need to scan enormous quantities of possible results and ultimately find real discoveries in mountains of data”.

“I am pleased about the expressed appreciation for our research. Winning the Rousseeuw Prize is the outcome of a long process, planted and cultivated in Israel for many years, in a fertile academic substrate, that grew into the global world of science. I hope that even in these difficult times for Israel and the region, our societies will allow academia to sustain an open and healthy environment, enabling continued scientific growth that benefits mankind with no borders” – Prof. Benjamini

How a Brain Parasite Becomes a Brain Cure

Written by Hilary on 4 August 2024. Posted in Newsroom.

TAU research paves the way to brain healing with parasites

Have you ever imagined that parasites could be beneficial for brain diseases? TAU Researchers have reengineered Toxoplasma gondii, the ‘cat parasite,’ transforming it from a feared threat into a groundbreaking tool for delivering drugs directly to the brain. This surprising innovation not only overturns our expectations but also opens new possibilities for treating neurological disorders.

In a breakthrough study by an international team of scientists led by researchers from Tel Aviv and Glasgow Universities, the ‘cat parasite’ Toxoplasma gondii was engineered to deliver drugs to the human brain. The study was led by Prof. Oded Rechavi from the Department of Neurobiology and the Sagol School of Neuroscience at Tel Aviv University, together with his PhD student Dr. Shahar Bracha, and with Prof. Lilach Sheiner, an Israeli scientist and toxoplasma expert from the University of Glasgow in Scotland. The results were published in the leading scientific journal Nature Microbiology.

“One of the biggest challenges in treating neurological diseases is getting through the blood-brain barrier (BBB),” explains Prof. Rechavi. “It is tough to deliver drugs to the brain via the bloodstream, and this is especially true for large molecules such as proteins, the critical ‘machines’ that carry out many important functions inside the cell”.

Toxoplasma gondii – the ‘cat parasite’

The creative solution proposed by the TAU team utilizes the unicellular parasite Toxoplasma gondii, which can infect a vast variety of organisms, but reproduces only in the guts of cats. The parasite is very effective in infecting humans, with an estimated third of the global population infected at some point in their lives. Prof. Rechavi explains: “Most people don’t even feel the infection or only experience mild flu-like symptoms.

Dormant Parasite Sparks New Treatment

The parasite is, however, dangerous for people with immune failure due to conditions like AIDS, and for fetuses whose immune system has not yet developed. This is why pregnant women are advised not to eat raw meat which might contain the parasite, and to stay away from cats, which might deliver it through their feces. While ridding the body of the parasite, a healthy immune system has only limited access to the brain, and the parasite remains in the brain throughout the carrier’s lifetime”.

The parasite’s ability to penetrate the human brain and survive there in a dormant state, without reproducing, made it a perfect candidate for the researchers’ novel approach: genetically engineering Toxoplasma gondii to secrete therapeutic proteins.

Can Parasites Deliver Medications to the Brain?

“The parasite has three distinct secretion systems and we ‘hitched a ride’ on two of them”, says Prof. Rechavi. “We did not intervene with the first system, which secretes proteins outside the neurons. The second system ‘shoots’ a ‘harpoon’ into the neuron, to enable penetration. Once inside, the parasite forms a kind of cyst that continues to secrete proteins permanently. We engineered the parasite’s DNA to make it produce and secrete the proteins we want, which have therapeutic potential”.

“The parasite’s ability to pass through the BBB and communicate with the neurons, combined with our ability to engineer the parasite, generate a golden opportunity for solving the great therapeutic challenge of delivering medications to the brain”, says Prof. Sheiner.

Illustration of the activity of neurons

In this study, the team used transgenic model animals that were injected with parasites genetically engineered to produce and secrete proteins that travel into cell nuclei. Several lines of evidence proved that the proteins had been delivered to the target area and remained active in the neurons’ nuclei. One of these was especially eye-catching: a protein that, delivered by the parasite, entered the nuclei and cut out specific DNA segments, causing the transgenic animals’ brains to glow in the dark.

New Method for Rett Syndrome

This breakthrough can have far-reaching implications for a series of severe diseases. In the present study, the researchers specifically demonstrated the delivery of a protein called MeCP2, whose deficiency is associated with Rett syndrome. “This is a deadly syndrome caused by a deficiency in a single gene called MePC2 in brain cells, and our engineered Toxoplasma gondii was able to deliver it to the target cells”, says Prof. Rechavi. “But this is just one example. There are many other diseases caused by deficiency or abnormal expression of a certain protein”. To ensure the method’s safe and effective therapeutic implementation, for both drug delivery and genetic editing, a company named Epeius was established in collaboration with Ramot – the technology transfer company of Tel Aviv University, and with the University of Glasgow’s research and innovation services.

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