Newsroom – Page 4 – Australian Friends of Tel Aviv University

How Does the Brain Keep Calm?

Written by Hilary on 14 November 2024. Posted in Newsroom.

New Insight into Brain Stability: The Key Role of NMDA Receptors

Researchers at Tel Aviv University have made a fundamental discovery: the NMDA receptor (NMDAR)—long studied primarily for its role in learning and memory—also plays a crucial role in stabilizing brain activity. By setting the “baseline” level for activity in neural networks, the NMDAR helps maintain stable brain function amidst continuous environmental and physiological changes. This discovery may lead to innovative treatments for diseases linked to disrupted neural stability, such as depression, Alzheimer’s disease, and epilepsy.

The study was led by Dr. Antonella Ruggiero, Leore Heim, and Dr. Lee Susman from Prof. Inna Slutsky’s lab at the Faculty of Medical and Health Sciences at Tel Aviv University. Prof. Slutsky, who is also affiliated with the Sagol School of Neuroscience, heads the Israeli Society for Neuroscience and directs the Sieratzki Institute for Advances in Neuroscience. Additional researchers included Dr. Ilana Shapira, Dima Hreaky, and Maxim Katsenelson from the Faculty of Medical and Health Sciences at Tel Aviv University, and Prof. Kobi Rosenblum from the University of Haifa. The study was published in the prestigious journal Neuron.

“In recent decades, brain research has mainly focused on processes that allow information encoding, memory, and learning, based on changes in synaptic connections between nerve cells”, says Prof. Slutsky.

“But the brain’s fundamental stability, or homeostasis, is essential to support these processes. In our lab, we explore the mechanisms that maintain this stability, and in this study, we focused on the NMDAR—a receptor known to play a role in learning and memory”, Slutsky continues.

This comprehensive project used three primary research methods: electrophysiological recordings from neurons in both cultured cells (in vitro) and living, behaving mice (in vivo) within the hippocampus, combined with computational modeling (in silico). Each approach provided unique insights into how NMDARs contribute to stability in neural networks.

Dr. Antonella Ruggiero studied NMDAR function in cultured neurons using an innovative technique called “dual perturbation”, developed in Prof. Slutsky’s lab. “First, I exposed neurons to ketamine, a known NMDAR blocker”, she explains. “Typically, neuronal networks recover on their own after disruptions, with activity levels gradually returning to baseline due to active compensatory mechanisms. But when the NMDAR was blocked, activity levels stayed low and didn’t recover. Then, with the NMDAR still blocked, I introduced a second perturbation by blocking another receptor. This time, the activity dropped and recovered as expected, but to a new, lower baseline set by ketamine, not the original level”. This finding reveals the NMDAR as a critical factor in setting and maintaining the activity baseline in neuronal networks. It suggests that NMDAR blockers may impact behavior not only through synaptic plasticity but also by altering homeostatic set points.

Building on this discovery, Dr. Ruggiero sought to uncover the molecular mechanisms behind the NMDAR’s role in tuning the set point. She identified that NMDAR activity enables calcium ions to activate a signaling pathway called eEF2K-BDNF, previously linked to ketamine’s antidepressant effects.

How NMDARs Set the Brain’s Activity Baseline

Leore Heim investigated whether the NMDAR similarly affects baseline activity in the hippocampus of living animals. A major technical challenge was administering an NMDAR blocker directly to the hippocampus without affecting other brain areas, while recording long-term activity at the individual neuron level. “Previous studies often used injections that delivered NMDAR blockers across the entire brain, leading to variable and sometimes contradictory findings,” he explains. “To address this, I developed a method combining direct drug infusion into the hippocampus with long-term neural activity recording in the same region. This technique revealed a consistent decrease in hippocampal activity across states like wakefulness and sleep, with no compensatory recovery as seen with other drugs. This strongly supports that NMDARs set the activity baseline in hippocampal networks in living animals”.

Mathematician Dr. Lee Susman created computational models to answer a longstanding question: Is brain stability maintained at the level of the entire neural network, or does each neuron individually stabilize itself? “Based on the data from Antonella and Leore’s experiments, I found that stability is maintained at the network level, not within single neurons,” he explains. “Using models of neural networks, I showed that averaging activity across many neurons provides computational benefits, including noise reduction and enhanced signal propagation. However, we need to better understand the functional significance of single-neuron drift in future studies”.

Prof. Slutsky adds: “We know that ketamine blocks NMDARs, and in 2008, it was FDA-approved as a rapid-acting treatment for depression. Unlike typical antidepressants like Cipralex and Prozac, ketamine acts immediately by blocking NMDARs. However, until now, it wasn’t fully understood how the drug produced its antidepressant effects. Our findings suggest that ketamine’s actions may stem from this newly discovered role of NMDAR: reducing the activity baseline in overactive brain regions seen in depression, like the lateral habenula, without interfering with homeostatic processes. This discovery could reshape our understanding of depression and pave the way for developing innovative treatments”.

Eyes Wide Shut: Bats Can Navigate Long Distances Using Sound Alone

Written by Hilary on 12 November 2024. Posted in Newsroom.

Researchers found that bats can create a mental “sound map” of their environment.

A new study by Tel Aviv University and the Steinhardt Museum of Natural History has proven, for the first time, that bats can navigate in nature over many kilometers using only echolocation, without relying on other senses. The researchers explain: “It’s well-known that bats are equipped with a natural sonar, allowing them to emit sound waves that bounce back from nearby objects, helping them navigate. However, it’s also known that bats use their sense of sight during flight. Laboratory studies have shown that bats can navigate within enclosed spaces using only echolocation — but sonar ‘sees’ only about 10 meters ahead, so what happens under natural conditions, in open areas stretching over many kilometers? Can bats rely solely on echolocation for long-distance navigation?” In this study, that question was explored in depth for the first time.

They Follow the Echo

The research was led by Prof. Yossi Yovel of Tel Aviv University’s School of Zoology, Sagol School of Neuroscience, and Steinhardt Museum of Natural History, along with Dr. Aya Goldshtein, formerly a doctoral student of Prof. Yovel and currently a researcher at the Max Planck Institute in Germany. Additional partners from Tel Aviv University included Prof. Sivan Toledo of the Blavatnik School of Computer Science; Xing Chen, Dr. Eran Amichai, and Dr. Arjan Boonman of the School of Zoology; and Lee Harten of the Sagol School of Neuroscience. Prof. Ran Nathan and Dr. Yotam Orchan of the Hebrew University and Prof. Iain Couzin of the Max Planck Institute in Germany also participated in the study, which was published in the journal Science.

The innovative research carried out over six years, utilized a unique tracking system installed in Israel’s Hula Valley. Using this GPS-like technology, the researchers could track the flight of tiny bats from the species known as Kuhl’s pipistrelle, each weighing only six grams —— the smallest mammal ever to be monitored in this way.

For the study, the researchers collected around 60 bats from their roost in the Hula Valley area and moved them about three kilometers away from the roost — still within their familiar habitat. A tag was attached to each bat, and the eyes of some were covered with a cloth strip, temporarily preventing them from seeing during flight, though they could remove the covering with their feet upon landing. In addition, the researchers employed techniques to temporarily disrupt the bats’ sense of smell and magnetic sense, thereby creating conditions in which they would be able to find their way home using only echolocation. Remarkably, the bats managed to return to their roost without difficulty.

In the second phase, the researchers built a computerized acoustic model of the bats’ natural environment in the Hula Valley. Prof. Yovel explains: “This model is based on a 3D map of the area where the bats navigate, reflecting the echoes that the bat hears as it uses echolocation to journey through its surroundings. In examining the bats’ flight paths, we discovered that they choose routes where the echoes contain a lot of information, which helps them navigate. For example, an area rich in vegetation, such as bushes and trees, returns echoes with more information than an open field, making bats less likely to fly over open terrain. We also found that some areas are characterized by distinct echoes, which are picked up by the bats. These findings strengthened our hypothesis that in any given area, bats know where they are based on the echoes. The bats effectively create an acoustic map in their head of their familiar environment, which includes a variety of active ‘sound landmarks’ (echoes) — just as every sighted person has a visual map of their everyday surroundings”.

פרופ' יוסי יובל

Hyperbaric Oxygen Therapy: A Promising Treatment for PTSD Symptoms

Written by Hilary on 11 November 2024. Posted in Newsroom.

Biological damage in PTSD sufferers can be treated with a specialized protocol.

Researchers at Tel Aviv University and the Sagol Center for Hyperbaric Medicine and Research at the Shamir Medical Center have demonstrated that hyperbaric oxygen therapy (HBOT) improves the condition of PTSD sufferers who have not responded to psychotherapy or psychiatric medications. The researchers: “Our unique therapeutic protocol affects the biological brain ‘wound’ associated with PTSD, and effectively reduces typical symptoms such as flashbacks, hypervigilance, and irritability. We believe that our findings give new hope to millions of PTSD sufferers and their families, all over the world”.

The study was led by Prof. Shai Efrati and Dr. Keren Doenyas-Barak from the Faculty of Medical and Health Sciences at Tel Aviv University and the Sagol Center for Hyperbaric Medicine and Research at the Shamir Medical Center. Other contributors include Dr. Ilan Kutz, Gabriela Levi, Dr. Erez Lang, Dr. Amir Asulin, Dr. Amir Hadanny, and Dr. Ilia Beberashvili from the Shamir Medical Center, and Dr. Kristoffer Aberg and Dr. Avi Mayo from the Weizmann Institute. The paper was published in The Journal of Clinical Psychiatry.

“At present, we treat hundreds of PTSD sufferers every day”

Prof. Efrati: “Due to our unfortunate circumstances, Israel has become a global leader in the field of PTSD. Before the Hamas attack on Oct. 7, 2023, approximately 6,000 IDF veterans had been recognized as PTSD sufferers, with many others, both soldiers and citizens, not yet acknowledged by the authorities. Following Oct. 7 and the ensuing war, these numbers have risen sharply. Tens of thousands of soldiers, and much larger numbers of civilians, are likely to be diagnosed with PTSD. The world-leading Sagol Center for Hyperbaric Medicine, the largest of its kind in the world, is rising to the challenge – with a comprehensive therapeutic array comprising hyperbaric facilities combined with diverse mental health professionals, psychologists and psychiatrists. At present, we treat hundreds of PTSD sufferers every day, aiming to reach one thousand patients per year”.

Dr. Doenyas-Barak: “PTSD (Post-Traumatic Stress Disorder) is defined as the mental outcome of exposure to a life-threatening event. About 20% of those who have undergone such an experience will develop PTSD, which can lead to substantial social, behavioral, and occupational dysfunctions. In extreme cases, the disorder can severely impact their quality of life, family life, and professional performance. Symptoms include a range of emotional and cognitive changes, nightmares and flashbacks, hypervigilance, irritability, and avoidance – so as not to trigger traumatic experiences. In many cases, PTSD is resistant to psychotherapy and common psychiatric medications. Past studies on therapy-resistant sufferers have found changes in the structure and function of brain tissues, or a ‘biological wound’ that explains such treatment resistance. In our study, we wanted to determine whether hyperbaric therapy can help these patients”.

Testing HBOT for PTSD Relief

The study, which began in 2019 and ended in the summer of 2023, included 98 male IDF veterans diagnosed with combat-associated PTSD, who had not responded to either psychotherapy or psychiatric medications. Participants were divided into two groups: one group received HBOT treatment, breathing pure high-pressure oxygen, while the other underwent the same procedure, but received a placebo treatment, breathing regular air. 28 members of each group completed the process and the following evaluation.

Dr. Doenyas-Barak: “The HBOT was administered in accordance with a unique treatment protocol developed at our Center. Every patient is given a series of 60 two-hour treatments in our hyperbaric chamber, during which they are exposed to pure 100% oxygen at a pressure of 2 atmospheres (twice the normal air pressure at sea level). Our protocol specifies alternately breathing oxygen and regular air: every 20 minutes the patient removes the oxygen mask and breathes regular air for five minutes. The drop in oxygen level, at the tissue level, activates healing processes and thus enhances the therapeutic effect”.

Functional MRI before and after HBOT. Photo credit: The Shamir Medical Center.

The results were encouraging, with improvements observed both at the clinical level and in fMRI imaging. The group that received hyperbaric therapy showed improved connectivity in brain networks, alongside a decline in all typical PTSD symptoms. In the placebo group, on the other hand, no change was observed in either the brain or clinical symptoms. Prof. Efrati: “Our study demonstrated that HBOT induces biological healing in the brain of PTSD sufferers. Curing the biological wound also impacts clinical symptoms. We believe that HBOT, based on the special protocol we have developed, can bring relief to numerous PTSD sufferers worldwide, allowing them to resume a normative life in their community and family”.

Prof. Efrati emphasizes:

“Patients suffering from PTSD should undergo HBOT only at professional hyperbaric centers, where treatment is delivered by multidisciplinary teams experienced in trauma care. Unsupervised, private hyperbaric chambers are unable to provide a proven, effective protocol. Additionally, patients must receive a thorough professional evaluation to ensure they are suitable for HBOT and to determine what additional support is needed throughout their treatment journey”.

Israel’s Ministry of Defense funds HBOT for veterans who need it.

Buzzed but Never Tipsy: Hornets’ Remarkable Alcohol Tolerance

Written by Hilary on 10 November 2024. Posted in Newsroom.

Oriental hornets are the only animals able to drink unlimited amounts of alcohol.

A new study from the School of Zoology and the Steinhardt Museum of Natural History at Tel Aviv University has revealed that the Oriental hornet is the only known animal capable of chronically consuming alcohol in high concentrations with almost no negative effects on its health or lifespan. The research team says, “This is a remarkable animal that shows no signs of intoxication or illness even after ingesting huge amounts of alcohol.”

The research was conducted under the leadership of postdoctoral fellow Dr. Sofia Bouchebti from Prof. Eran Levin’s laboratory at Tel Aviv University’s School of Zoology and the Steinhardt Museum of Natural History. The study was published in the journal Proceedings of the National Academy of Sciences of the United States of America (PNAS).

The researchers explain that alcohol is commonly produced in nature through the breakdown of sugars by yeasts and bacteria, primarily found in ripe fruits and nectar. Although alcohol contains nearly twice the amount of energy as sugar, it is toxic to most animals — including us humans — with occasional consumption, and especially with chronic use. Among the animals known to consume alcohol are fruit flies, which show signs of alcohol poisoning even at relatively low concentrations, and treeshrews — mammals native to East Asia that feed on ripe, alcohol-rich fruits — who show symptoms such as fatty liver and other effects indicative of alcoholism after consuming low concentrations of alcohol continuously for several days.

As for humans, many of us like consuming alcohol. Humans domesticated the wine grape around 10,000 years ago, and compared to other animals, we can tolerate and often enjoy consuming relatively high amounts of alcohol. However, as we know, alcohol has significant effects on behavior, cognition, and, of course, health, with a host of diseases linked to its consumption.

Hornets Can Handle Their Liquor

In the new study, the research team tested the Oriental hornet’s ability to consume alcohol and break it down. Dr. Bouchebti explains: “The hornets naturally store yeasts in their digestive system, which provides them with a unique environment that allows the yeast to develop and reproduce, creating new strains. One explanation is that hornets transfer yeasts to fruits, which indirectly contributes to the production of wine. In our study, we labeled the alcohol consumed by the hornets with a heavy carbon isotope. As the alcohol is metabolized, it breaks down into carbon dioxide, which is exhaled. By measuring the amount of labeled carbon dioxide emitted, we were able to estimate the speed at which the alcohol was broken down. The findings were surprising; we were amazed to see the rapid rate at which the hornets metabolized the alcohol”.

In the next stage, the researchers sought to determine whether the Oriental hornet ever becomes intoxicated. Does increased alcohol consumption affect their behavior, for example causing aggression or impacting their nest-building abilities? Here too, the findings were surprising: even when consuming high concentrations of alcohol (80 percent alcohol as the sole source of nutrition) there was no noticeable effect on the hornets’ behavior. In the final phase of the study, the researchers tested whether alcohol had any impact on the hornets’ lifespan and health. Once again, they were amazed to discover that no differences were found between the lifespan of hornets that consumed only alcohol for their entire lives (three months) and hornets that consumed sugar water.

No Hangovers Here

Prof. Levin concludes: “To the best of our knowledge, Oriental hornets are the only animal adapted to consuming alcohol as a metabolic fuel. They show no signs of intoxication or illness, even after chronically consuming huge amounts of alcohol, and they eliminate it from their bodies very quickly. In a bioinformatics analysis of the Oriental hornet’s genome, conducted by Prof. Dorothee Huchon, it was discovered that the hornet possesses several copies of the gene responsible for producing the enzyme that breaks down alcohol; this genetic adaptation may be related to their incredible ability to handle alcohol. We propose that the ancient relationship between hornets and yeast led to the development of this adaptation. Furthermore, while alcohol-related research is highly advanced, with 5.3 percent of deaths in the world linked to alcohol consumption, we believe that, following our research, Oriental hornets could potentially be used to develop new models for studying alcoholism and the metabolism of alcohol”.

Chemistry Researchers Awarded Prestigious ERC Synergy Grant

Written by Hilary on 5 November 2024. Posted in Newsroom.

The European Research Council (ERC) has announced the results of the 2024 ERC Synergy Grant Call. Among the funded projects is an international collaboration, coordinated by Tel Aviv University researchers and titled “Unravelling the Mysteries of Vibrational Strong Coupling” (UNMYST). The prestigious ERC Synergy grants are awarded to leading researchers in their fields across all areas of science, and it is intended to promote groundbreaking interdisciplinary research.

The UNMYST project is an international collaboration between leading experimental and theoretical groups, including Dr. Tal Schwartz and Prof. Sharly Fleisher from the School of Chemistry at Tel Aviv University, Prof. Abraham Nitzan, an emeritus of the School of Chemistry at Tel Aviv University and a Donner Professor of Physical Sciences in University of Pennsylvania, Prof. Thomas Ebbesen and Cyriaque Genet from the University of Strasbourg, France, Prof. Angel Rubio and Dr. Michael Ruggenthaler from the Max Planck Institute for the Structure and Dynamics of Matter, Germany, and Dr. Dominik Sidler from the Paul Scherrer Institute in Switzerland.

According to the project coordinator Dr. Tal Schwartz, the UNMYST project will explore how tailoring the electromagnetic environment influences chemical and physical processes in molecular systems in the so-called “strong light-matter coupling” regime. The researchers anticipate that the results of the project will establish fundamental insights into such novel phenomena, which will lead to future breakthroughs with far-reaching implications for chemistry and materials sciences.

A Letter from TAU President Welcoming the New Academic Year

Written by Hilary on 3 November 2024. Posted in Newsroom.

“May the hostages come back, the wounded heal, and the displaced return to their homes”.

This week, we begin the 2024-5 academic year, against the backdrop of the bloody war that rages on, and while we still lack a clear sense of how this war will unfold, particularly in relation to Iran.

The anguish over the hostages weighs heavily on us all. It’s hard to believe that over a year after the horrific disaster of October 7, many hostages are still languishing in the hellish tunnels of Gaza, with the bodies of many others held there as bargaining chips. We cannot win this war without bringing everyone home. Added to this is the daily sorrow and mourning for our soldiers, including members of our university community, who have fallen or been injured while defending us, as well as for the civilians who have fallen victim to terrorist acts across Israel. Our concern for the soldiers on the front lines and the tens of thousands of Israelis in the South and North–who either remain vulnerably in their homes or were displaced by circumstances–is unrelenting.

Yet, we have no other country, and fight for it we must. This is what the parents and grandparents of many of us did even before the establishment of Israel, and now it’s our turn. Our extraordinary young generation, with so many risking their lives on the battlefield, places a weighty responsibility on us, the older generation. What are we doing, as a university, and what more must we do in this crucial period?

One of our primary tasks, both last year and this year, is to do everything in our power to ensure that the reservist soldiers studying with us, as well as students who are spouses of soldiers, can complete the academic year successfully. Last year, we provided financial, academic, and emotional support and we will continue to do so this year as well. The emergency fund we established with the help of friends of the university in Israel and around the world has greatly assisted us in this endeavor.

Second, we succeeded last year in containing tensions on campus triggered by the war while maintaining a democratic space and protecting the human and civil rights of everyone. Members of our university community, Jews and Arabs, left-leaning and right-leaning, are equally dear to us. Open and free discussion on any topic is the essence of academia, and we will uphold this principle this year as well.

Third, a primary mission we are focused on is bringing as many Israeli researchers studying abroad back to Tel Aviv University as we have done in previous years. These researchers represent the next generation of academia; they embody the scientific and humanistic pursuits without which we have no future. Israel may seem less attractive to some of them at present, but I am confident that we will weather this crisis and emerge stronger.

Fourth, the growing boycott of Israeli academia worldwide (BDS) affects us all. Universities across the country have united and are working collaboratively to mitigate the impact of the boycott through legal and other means. We’ve had some successes, but there is still a long way to go.

Fifth, from October 7 to this day, the university–as an institution and as a community–has been involved in numerous volunteer activities. Days after October 7, our community members volunteered in the South and North, both in their areas of expertise and in agriculture and other manual work. We will continue to do so this coming year, hopefully in collaboration with local authorities in the South and North. A few months after the war broke out, we established the Post-Trauma Center, treating hundreds of people, both civilians and soldiers. Here, too, the generous financial support of our friends in Israel and abroad has been invaluable.

Sixth, we will continue to defend academic freedom and the autonomy of universities in Israel against those who seek to harm them. Academic freedom is essential for free thought, intellectually challenging education, and groundbreaking research. Without these, we will become a third-world country. I assure you that I will protect our academic freedom as one of my most cherished values.

These are the special missions that characterize this period. But equally important: last year, we carried on teaching and doing research as if – or almost as if – there were no war. We, the university and Israel as a whole, do not have the privilege to stop “producing” doctors, engineers, psychologists, social workers, scientists, and humanist intellectuals. Nor do we have the privilege to stop advancing research. This is the source of our resilience, the safeguard of our future, and we cannot forsake it, not in times of peace and certainly not in times of war.

I thank you all – academic and administrative staff – for your hard work this past year to meet the challenges we set for ourselves, and our friends in Israel and abroad – for your generous support of the University and Israel. And to you, our students – thank you for your patience with us. We are doing our utmost so that you derive the maximum benefit, and hopefully some enjoyment, from studying at Tel Aviv University.

I wish you a successful year, and may peace and tranquility return to our land. May the hostages come back, the wounded heal, and the displaced return to their homes.

Yours always,

Ariel Porat

TAU President

TAU Breakthrough Reveals Mechanism That Eliminates Tumors

Written by Hilary on 3 November 2024. Posted in Newsroom.

Researchers identified a mechanism that eliminates tumors—even those resistant to immunotherapy.

A technological breakthrough by medical researchers at Tel Aviv University enabled the discovery of a cancer mechanism that prevents the immune system from attacking tumors. The researchers were surprised to find that reversing this mechanism stimulates the immune system to fight the cancer cells, even in types of cancer considered resistant to prevailing forms of immunotherapy. The breakthrough was led by Prof. Carmit Levy, Prof. Yaron Carmi, and PhD student Avishai Maliah from TAU’s Faculty of Medical and Health Sciences. The paper was published in the leading journal Nature Communications.

Prof. Levy: “It all happened by coincidence. My lab studies both cancer and the effects of ultraviolet (UV) radiation from the sun on our skin and body – both of which are known to suppress the immune system. Cancer suppresses approaching immune cells and solar radiation suppresses the skin’s immune system. While in most cases, we cancer researchers worldwide focus on the tumor and look for mechanisms by which cancer inhibits the immune system, here we proposed a different approach: investigating how UV exposure suppresses the immune system and applying our findings to cancer. The discovery of a mechanism that inhibits the immune system opens new paths for innovative therapies”.

What Surprising Findings Emerged from the Research?

Prof. Levy adds: “With this idea in mind, I asked my colleague Prof. Yaron Carmi, a global expert on the immune system, to join the study. Avishai Maliah, an MD/PhD candidate in my lab, led the project. The first stage was a comprehensive investigation of changes in the skin induced by exposure to UV, using a mouse model. Avishai examined the behavior of dozens of proteins post-UV exposure and surprisingly discovered a significant rise in the level of a relatively unexplored protein called Ly6a. This unexpected finding led us to investigate further, to understand the protein function and whether it is involved in the immune suppression process”.

Prof. Carmi explains: “It’s important to understand a basic aspect of the immune system’s function. Our natural immune system is very efficient and very powerful, but it contains quite a few brakes and controls, to prevent overactivity that can cause autoimmune diseases – in which the body attacks itself. When our skin is exposed to UV radiation from the sun, our immune system responds immediately: blood vessels expand, DNA is repaired wherever possible, and cells with mutations are identified and removed. At the same time, a strong control system with numerous brakes is also activated to prevent overactivity”.

How Does UV Exposure Affect Immune Response?

Prof. Levy: “The use of sunlight to suppress autoimmune diseases of the skin – when the skin’s immune system overreacts – has been known for years. Phototherapy is basically the application of UV radiation to treat patients with autoimmune diseases, such as psoriasis, vitiligo and more, because ultimately UV suppresses the skin’s immune system”.

Avishai Maliah: “We found that after exposure to UV radiation, the immune system’s T cells – that play a critical role in fighting cancer – begin to express high levels of the protein Ly6a. We suspected that Ly6a serves as a brake through which UV inhibits the immune system, and that by releasing this brake, optimal activation of the immune system might be resumed”.

Prof. Levy: “We were surprised to discover that this protein, Ly6a, is also overexpressed in cancer tumors – apparently inhibiting T cells. Having found this in two types of cancer, melanoma skin cancer and colon cancer, we have reason to believe that the same thing happens in other cancers as well. Evidently, we have discovered a general mechanism through which cancer tumors desensitize the immune system. Avishai treated cancer with Ly6a antibodies, and amazingly the tumors were significantly reduced. Moreover, cancers resistant to known treatments reacted substantially to Ly6a antibodies”. The new discovery can have practical implications in immunotherapy – treating cancer by enhancing the response of the immune system.

Prof. Carmi: “Immunotherapy has revolutionized the treatment of cancer. However, about 50% of the patients do not respond to the currently prevailing treatment – the protein PD1. We discovered a new protein, Ly6a, and found that its antibody eradicated tumors in our model animals – even those resistant to PD1 therapy. We are currently working to translate our findings into a drug for human cancer patients, hoping to offer an effective new treatment”.

Prof. Beatriz Magaloni: 2024 BMI Prize Laureate

Written by Hilary on 3 November 2024. Posted in Newsroom.

The Faculty of Social Sciences at Tel Aviv University has announced that it is awarding the 2024 BMI Prize to Prof. Beatriz Magaloni from Stanford University, in recognition of her significant contributions to the study of authoritarianism. This esteemed prize is presented annually by the The Boris Mints Institute for Strategic Policy Solutions to Global Challenges and highlights the impact of a senior researcher’s work in specific academic fields.

Prof. Beatriz Magaloni is a distinguished scholar in political science, renowned for her groundbreaking research on autocratic regimes and their electoral processes. She holds the position of Graham H. Stuart Professor of International Relations and is a Senior Fellow at the Freeman Spogli Institute for International Studies at Stanford University. Her work has become foundational in understanding multi-party autocracies, which are increasingly prevalent forms of governance globally.

Prof. Magaloni’s research addresses critical questions regarding why autocratic regimes opt for multi-party elections and the implications of these elections for democracy. She elucidates the nuanced threats posed by civilian leaders who ascend to power through electoral means rather than military coups, offering vital insights into electoral behavior and regime stability.

Throughout her career, Prof. Magaloni has published extensively in leading journals, including the American Political Science Review and World Development. Her work is widely assigned in graduate and undergraduate courses, shaping the academic agenda for studies in comparative politics.

The award will be presented to Prof. Magaloni at the joint BMI-University of Donja Gorica Conference in Podgorica, Montenegro, on November 25th.

For further information about Prof. Beatriz Magaloni and her research, visit her profiles on Stanford University and the Carnegie Endowment.

“I Applied to Several Universities, But TAU’s Documentary Film Program Stood Out”

Written by AUFTAU on 10 October 2024. Posted in Newsroom.

Kristoffer Brugada is now in his second year of the international MFA in Documentary Cinema at Tel Aviv University. Currently working on his final project, a documentary on gay conversion therapy in the Philippines, Brugada reflects on his time in the program and the valuable lessons he’s gained.

Choosing TAU

In 2022, Brugada was searching for a master’s program that would help him grow as a filmmaker. “I applied to several universities, but Tel Aviv University’s program stood out. When I compared the curriculum, it felt more comprehensive in terms of what they teach and the topics discussed in class,” he says. A scholarship from TAU was another deciding factor in his choice.

MFA class

The diversity of the class and the collaborative nature of the program were also a strong draw. “Our class was a mix of ages and backgrounds, from filmmakers to urban planners. We had heated discussions, especially in the ethics class, but we learned so much from each other.

“Documentary filmmaking may be a solitary job, but making a film is a collaborative effort, and I loved that we supported each other.”

In addition, Brugada appreciates the progressive outlook of Tel Aviv University.

Refining Technique and Debating Ethics

As a filmmaker with 20 years of experience in TV production and independent documentaries, Brugada wasn’t new to the world of film. Yet, the program’s hands-on directing courses taught by top Israeli practitioners allowed him to experiment with new techniques and refine his craft. “I’ve done documentaries before, but the program pushed me to further develop my style. The directing courses gave me the freedom to experiment and find my voice,” he says.

Throughout the program, Brugada did several creative assignments that allowed him to apply what he was learning. These projects involved shooting, editing, and directing his own films. One of his notable assignments was a documentary on the Filipino community in Tel Aviv.

“I introduced my classmates to my culture through the Filipino workers here in Israel.”

His project on the annual beauty pageants for caregivers, a beloved tradition from the Philippines that has made its way to Israel, was a hit with his classmates. “They found it fascinating how these caregivers, despite their hard work, still found joy in community events.”

Brugada’s short on beauty pageants in Israel

The university provided equipment, including Sony FS5 cameras and editing suites, but Kristoffer brought his own gear, which allowed him to film more flexibly.

“The equipment at the university is great. As a teacher back in the Philippines, I really appreciated the quality of the resources available at TAU.”

As for the theoretical courses, the one on ethics in documentary filming stood out the most. The course focused on the responsibilities filmmakers have when dealing with real people: “We have to assess what we can show and how it impacts both the audience and the subjects. I really loved those discussions,” he recalls. The program’s emphasis on ethical considerations helped him navigate sensitive topics, like the subject of his final film, with care and respect.

On top of that, getting to know more about the Israeli cinema landscape and learning about new theories of documentary filmmaking was something Brugada liked a lot.

Bringing the Vision to Life

During the second year, students work on their final project, a documentary film that they create individually or in teams. Brugada’s project, Going Straight, tackles a sensitive topic of gay conversion therapy in the Philippines.

“I wanted the film to be a venue for discussion about extreme fundamentalism and giving grace, love, and understanding instead of judgment.”

During Pride March shoot in Tel Aviv

The topic has been on his mind since 2017, but it was at TAU that he found the support and resources to bring the project to life.

“The university’s Blavatnik Fund gave me financial support to finish the film.”

TAU professors, including Ran Tal and Netalie Braun, provided guidance on how to shape the narrative and decide which scenes to include. “We had to present sample scenes to the final film committee, who then gave us advice on which direction to take. Their feedback was crucial in helping me refine the story,” he says.

Brugada (right) with fellow students during Cinematography class

Now in post-production stage, Brugada plans to submit Going Straight to international festivals, with hopes of premiering it at a top-tier event.

“I want to show it to the world. It’s a story that needs to be told, and I’m grateful to TAU for giving me the support to tell it.”

Filmmaking, Teaching, and New Career Milestones

Brugada’s journey as a filmmaker doesn’t stop at the completion of his final project. In fact, he’s already sharing his knowledge and experience with the next generation of filmmakers.

“I’ve been teaching documentary production, screenwriting, and television production for a while now.”

After finishing his MFA, he hopes to continue teaching, potentially at the master’s level, and is even considering pursuing a PhD.

In addition, Brugada has also been invited to serve on the jury at the prestigious Japan Prize, a festival focused on educational media. “It’s a great opportunity to engage with filmmakers from around the world and see the incredible work being done in the field of educational film and television,” he says.

With his film nearing completion, his teaching responsibilities growing, and exciting opportunities like the Japan Prize ahead, Kristoffer’s career as a filmmaker and educator shows no signs of slowing down.

“I have other films that I shelved before that I would want to go back to and work on.”

Brugada remains dedicated to his craft and passionate about the stories he tells, grateful for the experiences and support he’s found at Tel Aviv University.

Why Do Employees Keep Their Ideas from Their Bosses?

Written by AUFTAU on 10 October 2024. Posted in Newsroom.

A new study from the Coller School of Management at Tel Aviv University sheds light for the first time on an important issue in the business world: employees withholding their inventions from the companies they work for. Although the law and/or employment contracts typically grant organizations the rights to their employees’ inventions, invention withholding is quite common. It carries serious implications for businesses, especially in knowledge-intensive industries. The study reveals alarming data: one out of every four employees in commercial organizations has withheld an invention from their employer at least once. In many cases, this withholding is done deliberately, with the intent to use the invention after leaving the organization. The research was led by Dr. Sarit Erez, in collaboration with Prof. Yaniv Shani and Prof. Abraham Carmeli from the Coller School of Management at Tel Aviv University. The study was published in the prominent journal Academy of Management Perspectives.

Coller School of Management.

Dr. Erez explains: “Commercial organizations, particularly those in knowledge-intensive industries, encourage innovation among their employees, and their success largely depends on those employees coming up with groundbreaking inventions. To protect companies’ rights to these inventions, legal systems and standard employment contracts typically grant the employer ownership of inventions made by their employees, while requiring employees to disclose any invention they have come up with at work. This allows the employer to obtain patents and protect the invention. To increase employees’ motivation to disclose their inventions, many companies implement incentive systems, offering financial grants and/or recognition, such as badges of honor, to inventors. But at the end of the day, when an employee comes up with a new invention, they are faced with a behavioral dilemma: should they fulfill their legal obligation and disclose the invention to their employer, knowing they will lose ownership, or violate their obligation and hold on to the possibility of capitalizing on their invention outside the company? Indeed, it is a common scenario to see people leave one organization and either join another in the same field or even start their own company — often to develop an invention conceived in their previous workplace”.

Video Credit: Dr. Sarit Erez.

Who Really Owns the Work You Create?

Dr. Erez continues: “These types of cases often end up in court, where an employer sues a former employee — or their new employer — alleging that they are using an invention that the employee conceived while working for them and that the patent rightfully belongs to the original employer. Having practiced law in the private sector for about 20 years, I often represented employees, employers, or employee organizations in disputes of this type. It became evident that the legal tools currently used to address this issue are not the most effective approach. I used to believe that management tools were designed to increase employees’ willingness to disclose their inventions and reduce their tendency to withhold them could be far more effective. But when I looked for academic research on this subject, I found only a handful, and even those focused mainly on the withholding of inventions in academia rather than in commercial organizations. It became clear to me that the issue of withholding inventions, which is so vital to the growth of knowledge-driven companies, had not yet been thoroughly explored in management strategy. With this study, we aimed to shed light on this important phenomenon and begin to address it from a business perspective”.

For the study, the researchers distributed an anonymous online questionnaire, asking inventors to report whether they had ever withheld one or more inventions from their employers. Participants were also requested to describe the event, including its reasons and circumstances. A total of 199 valid responses were collected. Dr. Erez details the findings: “54 participants, or 27 percent of the respondents, reported withholding at least one invention from the organization in which they worked. Of these, 28 percent explicitly stated that they did so to develop the invention themselves after leaving the organization or bringing it as a sort of ‘dowry’ to their next employer. The others cited a variety of reasons, some psychological and some financial. These included an emotional attachment and sense of ownership over the invention as a personal creation; fear that someone else would take credit; conflict with their employer; lack of trust in management; dissatisfaction with pay; and the belief that they would not be adequately compensated for an invention that would profit the organization”.

Changing the Work Culture

In the next phase, the researchers developed a unique and validated measurement scale, the first of its kind, to assess employees’ tendencies to either disclose or withhold inventions from their employers. The findings revealed that withholding or disclosing inventions are not simply opposite sides of the same behavior, but rather two fundamentally different behaviors: an employee might refrain from disclosing a certain invention for a variety of reasons (such as a heavy workload or the belief that the invention still requires development and is not ready to be disclosed). However, a deliberate and active decision to withhold an invention in order to prevent the transfer of ownership to the organization is a distinct behavior that may be influenced by completely different factors (for example, the employee’s feeling that they are poorly treated by the company regardless of the invention itself). Dr. Erez explains: “This distinction is extremely important for organizations seeking to address the problem. Actions taken by companies today, such as offering financial incentives or recognition to inventors, may encourage more disclosures to the organization. However, such measures may be less effective for employees who deliberately withhold a promising invention with the intention of using it further down the road, outside the organization”.

According to the researchers, this newly developed scale can serve as a foundation for further studies on the subject. Additionally, it can help employers build an effective innovation management strategy that minimizes the withholding of inventions within the organization.

Dr. Erez concludes: “In this study, we conducted an in-depth exploration of a widespread phenomenon that has long concerned legal professionals around the world, but so far has hardly been examined from a managerial perspective: employees in the business sector who withhold their inventions from the company that employs them. We urge researchers in academia to continue investigating this important topic, and call on employers to take notice: these behaviors exist, and it is crucial to address them. For our follow-up studies, we are developing management tools to help employers tackle the issue in all its complexity. We believe that with the right management strategies, it is possible to encourage disclosure and significantly reduce the withholding of inventions — preventing the need for legal battles down the line”.

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