Newsroom – Page 69 – Australian Friends of Tel Aviv University

TAU study among top 12 most important in the world

Written by AUFTAU on 10 January 2020. Posted in Newsroom.

Making the future accessible

Written by AUFTAU on 7 January 2020. Posted in Newsroom.

For many years, if you were vision impaired and wanted to read, you had to know Braille. Invented by Louis Braille, this unique form of tactile writing was introduced to the world in the 1830s and revolutionized access to information for people with visual disabilities. It allowed people the freedom to study, work, earn wages, and live independently, where before these options were extremely limited. By 1960, it was estimated that about 50% of children who were legally blind could read braille in the United States.

But in today’s digital age, new forms of accessibility have become more widespread. We wanted to find out – is Braille still relevant or on its way to becoming extinct?

From text to voice When we asked the staff at TAU’s Sourasky Central Library about books in Braille, we realized we were asking the wrong questions. The library doesn’t have any Braille books, investing instead of more modern forms of accessibility.

“We see accessibility as a very important issue,” says Naama Scheftlowitz, director of the Sourasky Central Library. “But Braille isn’t the most efficient solution these days. We offer students with disabilities more advanced forms consuming text, such as text-to-voice programs and audiobooks. Another benefit is that these forms of accessibility help not just vision-impaired people, but a wide range of students and library patrons. For example, students who don’t speak Hebrew and have difficulty reading, but listening makes it easier for them to study.”

^{Audio is the future}

Every computer at the library comes equipped with “Kolfix”, a text-to-voice program that can read any text on the screen out loud for the user. The library also offers students a subscription to iCast, an Israeli company that provides audiobooks, including translations of foreign books into Hebrew. The library’s search engine, DATA, also has a brand new feature that allows users to “voice search”, meaning to say the search term into a microphone instead of having to type it out.

Putting accessibility in the center

In the lobby of the library lives the Mia and Mila Pinkas Accessibility and Learning Assistance Center, maintained by the Dean of Students. Being placed in the lobby of the building means it’s centrally located on campus, and the library is right there for any assistance. It’s a spacious area containing work stations with advanced technological equipment, including magnification and reading software, and ergonomic equipment, aimed at making studying as accessible as possible for students with disabilities.

^{Some of the work stations at the Mia and Mila Pinkas Accessibility and Learning Assistance Center}

“The very fact that the Accessibility Center is located within the library,” Naama says, “raises awareness of the issue, and we keep up to date with new technologies and adopt them. We even serve as an address for various inquiries to assist with complex student needs.”

TAU study finds widespread misinterpretation of gene expression data

Written by AUFTAU on 27 December 2019. Posted in Newsroom.

Reproducibility of research data is a major challenge in experimental biology. As data generated by genomic-scale techniques increases in complexity, this concern is becoming more and more worrisome. RNA-seq, one of the most widely used methods in modern molecular biology, allows in a single test the simultaneous measurement of the expression level of all genes in a given sample. New research by a Tel Aviv University group identifies a frequent technical bias in data generated by RNA-seq technology, which often leads to false results. The study was conducted by Dr. Shir Mandelbaum, Dr. Zohar Manber, Dr. Orna Elroy-Stein and Dr. Ran Elkon at TAU’s Sackler Faculty of Medicine and George S. Wise Faculty of Life Sciences and was published on November 12 in PLOS Biology. “Recent years have witnessed a growing alarm about false results in biological research, sometimes referred to as the reproducibility crisis,” Dr. Elkon, lead author of the study, says. “This study emphasizes the importance of proper statistical handling of data to lessen the number of misleading findings.”

Removing bias from science

A main goal of RNA-seq experiments is to characterize biological processes that are activated or repressed in response to different conditions. The researchers analyzed dozens of publicly available RNA-seq datasets to profile the cellular responses to numerous stresses. During the research, the scientists noticed that sets of particularly short or long genes repeatedly showed changes in the expression level measured by the apparent number of RNA transcripts from a given gene. Puzzled by this recurring pattern, the team wondered whether it reflected some universal biological response common to different triggers or whether it stemmed from some experimental condition. To tackle this question, they compared replicated samples from the same biological condition. Differences in gene expression between replicates can reflect technical effects that are not related to the experiment’s biological factor of interest. Unexpectedly, the same pattern of particularly short or long genes showing changes in expression level was observed in these comparisons between replicates. This pattern is the result of a technical bias that seemed to be coupled with gene length, the researchers say. Importantly, the TAU researchers were able to show how the length bias they detected in many RNA-seq datasets led to the false identification of specific biological functions as cellular responses to the conditions tested. “Such misinterpretation of the data could lead to completely misleading conclusions,” Dr. Elkon concludes. “In practical terms, the study also shows how this bias can be removed from the data, thus filtering out false results while preserving the biologically relevant ones.”

Fibroblasts involved in healing spur tumor growth in cancer

Written by AUFTAU on 23 December 2019. Posted in Newsroom.

The connective tissue cells known as fibroblasts are vitally important for our recovery from injury. Sensing tissue damage, they gravitate to the site of a wound, instigating an inflammatory response that mends damaged tissue. A new Tel Aviv University study published in Nature Communications finds that fibroblasts also play a devastating role in the development of breast cancer. In cancer tumors, fibroblasts are triggered to respond to tissue damaged by tumors and create inflammation. This inflammation facilitates tumor growth as well as metastases in the lungs. “We have shown, for the first time, that in breast cancer these fibroblasts activate a ‘misguided’ wound healing response, responding to the tissue damage caused by the cancerous growth,” explains Prof. Neta Erez of TAU’s Sackler Faculty of Medicine, who led the research for the study. “Inhibiting these inflammatory signaling pathways may be beneficial in preventing metastatic relapse of breast cancer.” The study was conducted by former TAU student Yoray Sharon and TAU MD-PhD student Nour Ershaid in Prof. Erez’s lab at TAU’s Department of Pathology.

When tumors “hijack” repair functions

According to the study, the inflammatory response of fibroblasts not only supports local tumor growth in the breast, but it also creates a hospitable niche for metastatic growth in the lungs. “The fibroblasts are ‘activated’ and, because of this activation, they recruit immune cells and affect blood vessels,” adds Prof. Erez. “In other words, breast tumors ‘hijack’ the physiologic response to tissue damage to facilitate their growth, and create a niche in a distant organ, the lungs, by ‘remote control.'” Research for the study was performed using transgenic and transplantable mouse models of breast cancer, and validated in human samples of breast cancer and in human expression data. The researchers isolated fibroblasts in transgenic mice from different stages of breast carcinogenesis and profiled the expression of all their genes. They were then able to identify that the inflammation pathway is unregulated in cancer-associated fibroblasts, as compared with fibroblasts isolated from normal mammary glands. Finally, they performed functional experiments to understand the role of this pathway in breast cancer. “Our findings encourage the design of preclinical and clinical studies to examine the benefits of targeting the inflammation pathway in breast cancer, which may be effective in blocking metastatic relapse,” concludes Prof. Erez. “We are now studying the microenvironment of metastasis in an effort to identify targets for preventive intervention that may inhibit metastatic relapse.”

Bringing water to Tanzania

Written by AUFTAU on 18 December 2019. Posted in Newsroom.

Tel Aviv University’s future engineers flew to Africa to connect a school with 1,000 students to clean water

The children living in the villages of Babati district, Tanzania will now have drinkable water during the dry season, thanks to the student delegation from the Iby and Aladar Fleischman Faculty of Engineering. Unfortunately, there are still many places in the world where fresh, clean water, which many in developed countries take for granted, is a rare commodity. This is a common problem in many African countries. Each year, a delegation of engineers from the University of Tanzania sets out to build and improve water and electricity infrastructure. They do so within the framework of the “Engineers Without Borders” association, which works to promote and improve the quality of life of the Israeli population and developing populations worldwide. This year, as in previous years, students responded to the organization’s call, and a delegation of six students flew out during the Sukkot holiday break to contribute their time and knowledge, gained during their studies, and install systems at the regional school that would store 40,000 liters of water.

Months without water

“In Babati district, children sometimes have to walk 10 kilometers to reach clean water reservoirs, or settle for stagnant, contaminated water containing high levels of fluoride, which is detrimental to their health,” says Natalie Lubelchick, a University delegation graduate who is currently completing her master’s degree in Astrophysics. In Tanzania, during the dry season, the local rural population has to cope with three long, hot and dry months. In the absence of a solid infrastructure, the search for drinkable water sources is particularly difficult. If that’s not enough, the same water is also sought by wild animals, who often damage the few existing artificial water reservoirs. The mission of the Israeli delegation, which has sent volunteers for the fifth time, was to build a 40,000-liter water collection system from the rooftops of the Babati district school, where approximately a 1,000 students study, maintain existing systems installed by previous delegations, and also establish a new library, together with the local community. The project is overseen by Prof. Dror Avisar, head of the Water Research Center.

Working together: members of the delegation with locals from the school in Babati district

A glass of water a day for 1,000 children

After a 12-hour flight and before they embarked on two weeks of challenging physical labor, the delegation acquired all the necessary equipment they didn’t bring with them from Israel in Arusha, the city where they landed: dozens of huge 2000-liter containers, each to be installed in a school, as well as pipes and work tools. The main difficulty of this delegation and its predecessors is in being funded. “The ideal situation is that we would have a regular annual budget and know that our operations are guaranteed,” explains Natalie. Sometimes it’s unclear until the day of departure how much money will be at their disposal. On the eve of leaving the city for the village, the delegation members met the Tanzanian community representative, Julius, a school teacher who accompanies the project, and met his family. “He is the delegation’s angel and takes care of all of us,” says Natalie.

Smiles all around: Julius and his family with members of the delegation At the biggest, most central school in Babati district, where the largest system was about to be installed, the delegation was greeted with an enthusiastic welcome. Knowing that soon every student would be able to enjoy clean water was exciting for the children.

Hope and excitement: the delegation is recieved by the young students

At the principal’s office The first order of business for the delegation was teaching a group of boys and girls from local Scouts how to help with the construction and then later on how to maintain the systems. “The idea is not just to build a system, but to work collaboratively with the community, which includes education and instruction, which will lead to long-term results,” Natalie explains.

Left: local Scouts learning the new system. Left: children from the school using it to get clean water.

Left: local Scouts learning the new system. Right: children from the school using it to get clean water. The construction process included installing gutters, cleaning the water tanks and preparing the infrastructure. In one of the schools, where systems had already been installed in the past, the delegation had to replace containers, destroyed by elephants that came in search of water, and build anti-elephant concrete walls around them.

While the systems were being installed, the delegation members taught the students about proper use of the system and “water discipline”, and in return the students taught them local songs and dances.

Singing while you work: two members of the delgation with young students When it was clear that the work was progressing quickly and efficiently, the delegation decided to visit local families and get to know the community. “We started asking them questions about their daily lives and their needs,” Natalie says. “We realized that in addition to building the systems in schools, we also want to think of a home solution. Most people here live in extended families, sometimes numbering up to 50 people. So, a solution for one family can spare them a walk to the nearest water source, which can take hours, and also give them clean water, as opposed to reservoirs that are very polluted. Our challenge was to think of a simple, creative and inexpensive solution, using local materials, so we could easily distribute and duplicate it, and they could easily maintain the systems.”

Sometimes the villagers are forced to drink polluted water

As the largest system was assembled at the Minjingu Elementary School, the principal, together with the teachers, some of the parents and a thousand students, conducted a moving farewell ceremony. “They thanked us with a song, and promised to maintain the system, and we, for our part, got to see and understand how important the system is to them,” Natalie concludes.

Tiny insects become “visible” to bats when they swarm

Written by AUFTAU on 18 December 2019. Posted in Newsroom.

Bats use echolocation to hunt insects, many of which fly in swarms. In this process, bats emit a sound signal that bounces off the target object, revealing its location. Smaller insects like mosquitos are individually hard to detect through echolocation, but a new Tel Aviv University study reveals that they become perceptible when they gather in large swarms. The findings could provide new insights into the evolution of bat echolocation and explain why tiny insects are found in the diets of bats that seem to use sound frequencies that are too high to effectively detect them. The new research was conducted by Dr. Arjan Boonman and Prof. Yossi Yovel at TAU’s Department of Zoology and colleagues at Canada’s Western University. It was published in PLOS Computational Biology on December 12.

Modeling bat vision

Few studies have addressed what swarms of insects — as opposed to single insects — “look” like to bats. To find out, Dr. Boonman and colleagues combined three-dimensional computer simulations of insect swarms with real-world measurements of bat echolocation signals to examine how bats sense swarms that vary in size and density. They found that small insects that are undetectable on their own, such as mosquitos, suddenly become “visible” to bats when they gather in large swarms. They also discovered that the fact that bats use signals with multiple frequencies is well suited to the task of detecting insect swarms. These signals appear to be ideal for detecting an object if more than one target falls inside the echolocation signal beam at once. “Using simulations, we investigated something that could never have been measured in reality,” Dr. Boonman says. “Modeling enabled us to have full control over any aspect of an insect swarm, even the full elimination of the shape of each insect within the swarm.”

From insects to drones

The insect model the researchers used has a tiny mesh (skeleton) and minuscule legs and wings. “We are still adding new features, such as the bat’s acoustic beam or ears, which were not in the original model,” says Prof. Yovel. “We also developed a faster version of the algorithm. All of this will open a new world for us in which we can get echoes even from entire landscapes, so we can learn what a bat or sonar-robot would ‘see’ much more quickly.” The study could also affect technology being developed to improve defense systems. “The algorithms developed for this study could potentially be applied to radar echoes of drone swarms in order to lower the probability of detection by enemy radar,” Dr. Boonman explains. “Since drones are playing an ever more prominent role in warfare, our biological study could spawn new ideas for the defense industry.”

Eating in sync with biological clock could replace diabetes treatment

Written by AUFTAU on 17 December 2019. Posted in Newsroom.

Type 2 diabetics inject themselves with insulin, a hormone that regulates the movement of sugar into liver, muscle and fat cells, up to four times a day. But insulin injections are linked to weight gain and the loss of control of blood sugar levels. This triggers a vicious cycle of higher insulin doses, continuous weight gain, a higher incidence of cardiovascular disease and other complications. A new Tel Aviv University study finds that a starch-rich breakfast consumed early in the morning coupled with a small dinner could replace insulin injections and other diabetes medications for many diabetics. “The traditional diabetic diet specifies six small meals spread throughout the day. But our research proposes shifting the starch-rich calories to the early hours of the day. This produces a glucose balance and improved glycemic control among type 2 diabetics,” explains Prof. Daniela Jakubowicz of TAU’s Sackler Faculty of Medicine and Wolfson Medical Center’s Diabetes Unit. “We believe that through this regimen it will be possible for diabetics to significantly reduce or even stop the injections of insulin, and most of antidiabetic medications, to achieve excellent control of glucose levels.”

A hearty breakfast and a light dinner

According to the new research, our metabolism and biological clock are optimized for eating in the morning and for fasting during the evening and night, when we are supposed to be asleep. “But the usual diet recommended for type 2 diabetes consists of several small meals evenly distributed throughout the day — for example, three meals and three snacks daily, including a snack before going to sleep to prevent a drop in sugar levels during the night,” Prof. Jakubowicz says. “But the ‘6M-diet,’ as this is called, has not been effective for sugar control, so diabetics require additional medication and insulin. And insulin injections lead to weight gain, which further increases blood sugar levels,” Prof. Jakubowicz adds. The researchers studied 29 type 2 diabetes participants and compared a new “3M-diet,” more in alignment with our biological clock, with a control group on the traditional 6M-diet. The experimental 3M-diet comprises a meal of bread, fruits and sweets in the early hours of the morning; a substantial lunch; and a small dinner specifically lacking starches, sweets and fruits. The group on the traditional 6M-diet did not lose weight and did not experience any improvement of sugar levels, requiring an increase in medication and insulin doses. But the group on the 3M-diet not only lost weight but also experienced substantially improved sugar levels.

Making insulin injections unnecessary

“Their need for diabetic medication, especially for insulin doses, dipped substantially. Some were even able to stop using insulin altogether,” adds Prof. Jakubowicz. “In addition, the 3M-diet improved the expression of biological clock genes. This suggests that the 3M-diet is not only more effective in controlling diabetes. It may also prevent many other complications such as cardiovascular disease, aging and cancer, which are all regulated by the biological clock genes.” The upregulation of the biological clock gene expression in the 3M-diet might be the mechanism behind its success, as it enhances insulin secretion and improves sugar delivery into the muscles, creating a balanced daytime and nocturnal glucose metabolism. The researchers are now investigating the role certain proteins play in breakfast foods consumed by diabetics.

TAU partners with Columbia University for Dual Degree Program

Written by AUFTAU on 13 December 2019. Posted in Newsroom.

Tel Aviv University, Israel’s largest and most comprehensive higher education institution, today announced that it will launch the Dual Degree Program with Columbia University – a first-of-its-kind partnership at TAU that will provide undergraduate students from around the world with an opportunity to pursue an exceptional liberal arts education and earn two degrees. Transcending traditional study abroad opportunities, the program will enable students to simultaneously earn two bachelor’s degrees—one from each institution—upon completion of the four-year program. The multidisciplinary educational experience will offer students the best of both universities while empowering them to succeed in an increasingly complex and fast-changing world. “This is the first time that an Israeli university is collaborating with an elite American institution to offer a dual undergraduate program of this kind,” said Professor Raanan Rein, Vice President of Tel Aviv University.

Best of both worlds

The program will begin with students spending their first two years at Tel Aviv University, studying within one of six academic tracks in the International Program in the Liberal Arts at Lester and Sally Entin Faculty of Humanities. For the final two years, they will study at Columbia University, fulfilling its core curriculum and completing their majors. Dedicated Dual Degree Program advisors from both TAU and Columbia will be assigned to students as soon as they enroll, providing guidance and support on academics and student life. “I am especially excited about our partnership with Tel Aviv University, which is consistently ranked among the best academic institutions worldwide,” said Professor Lisa Rosen-Metsch, Dean, Columbia University School of General Studies. “By giving students the opportunity to study full time at a top-tier university in the Middle East before bringing them to study in the Ivy League, they will not only benefit from being immersed in a wide range of cultures and experiences, but will also make an immense contribution to the Columbia undergraduate classroom.” TAU’s B.A. in Liberal Arts provides a broad education in the humanities while allowing students to specialize in their areas of interest by choosing from six academic tracks, including Digital Culture and Communication, Jewish and Israel Studies, Middle Eastern Studies, Psychology, Philosophy, and Literature. The Dual Degree Program will welcome its inaugural class in the fall of 2020.

New Treatment Triggers Self-Destruction of Pancreatic Cancer Cells

Written by AUFTAU on 8 December 2019. Posted in Newsroom.

Research conducted on human pancreatic tumours transplanted in mice reveals promising results, TAU researchers say Pancreatic cancer is resistant to all current treatments. Patients have extremely poor chances of surviving for five years after being diagnosed. A new Tel Aviv University study finds that a small molecule has the ability to induce the self-destruction of pancreatic cancer cells. The research was conducted with xenografts — transplantations of human pancreatic cancer into immunocompromised mice. The treatment reduced the number of cancer cells by 90% in the developed tumors a month after being administered. The research holds great potential for the development of a new effective therapy to treat this aggressive cancer in humans. The study was led by Prof. Malca Cohen-Armon and her team at TAU’s Sackler Faculty of Medicine, in collaboration with Dr. Talia Golan’s team at the Cancer Research Center at Sheba Medical Center. It was published in the journal Oncotarget on October 22. “In research published in 2017, we discovered a mechanism that causes the self-destruction of human cancer cells during their duplication (mitosis) without affecting normal cells,” explains Prof. Cohen-Armon. “We have now harnessed this information to efficiently eradicate human pancreatic cancer cells in xenografts. The current results were obtained using a small molecule that evokes this self-destruction mechanism in a variety of human cancer cells. “The mice were treated with a molecule called PJ34, which is permeable in the cell membrane but affects human cancer cells exclusively. This molecule causes an anomaly during the duplication of human cancer cells, provoking their rapid cell death. Thus, cell multiplication itself resulted in cell death in the treated cancer cells.” A month after being injected with PJ34 daily for 14 days, the pancreatic cancer cells in the tumors of the treated mice experienced a relative drop of 90%. In one mouse, the tumor completely disappeared. “It is important to note that no adverse effects were observed, and there were no changes in the weight gain of the mice, nor in their behavior,” says Prof. Cohen-Armon. This mechanism acts efficiently in other types of cancer resistant to current therapies. The molecule PJ34 is being tested in pre-clinical trials according to FDA regulations before clinical trials begin.

A new, revolutionary way to simplify complex scientific calculations

Written by AUFTAU on 7 December 2019. Posted in Newsroom.

Researchers at Prof. Roy Beck’s lab have figured out a simple and accessible solution to a problem that even supercomputers struggle with: measuring entropy, the level of molecular disorder or randomness in a complext system. In complex physical systems, the interaction of internal elements is unavoidable, rendering entropy calculation a computationally demanding, and often impractical, task. The tendency of a properly folded protein to unravel, for example, can be predicted using entropy calculations. Now, a new Tel Aviv University study proposes a radically simple and efficient way of calculating entropy — and it probably exists on your own computer. “We discovered a way to calculate entropy using a standard compression algorithm like the zip software we all have on our computers,” explains Prof. Roy Beck of TAU’s School of Physics and Astronomy. “Supercomputers are used today to simulate the folding or misfolding of proteins in diseased states. Our study demonstrated that by using a standard compression algorithm, we can provide new insights into the physical properties of these proteins by calculating their entropy values using a compression algorithm.

A veriety of new solutions

“Having the ability to calculate entropy meets an urgent need to harness the incredible power of computer simulations to address urgent, timely problems in science and medicine,” Prof. Beck adds. The research was led by him and conducted by TAU PhD students Ram Avinery and Micha Kornreich. According to Prof. Beck, the research has endless applications. From biomedical simulations to basic research conducted in physics, chemistry or material science, the new algorithm would be simple to use on any computer. “A high school student used our concept to calculate the entropy of a complex physical system — the XY model,” says Prof. Beck. “Although this is considered a challenging problem with regard to entropy, the student accomplished it with very little guidance. This demonstrates how easily this method can be used by almost anybody to solve very interesting problems.”

A by-the-way discovery

The idea for the computational method first came about when Prof. Beck’s students, Avinery and Kornreich, discussed entropy from the point of view of information theory. They wondered how well this idea might work in practice rather than in theory. “They simulated a few standard physical systems with entropy values they can compare to,” says Prof. Beck. “Soon they found that the simulation data file size after compression rises and falls just as the expected entropy should. Shortly after that, they realized they could convert the compressed file size into a usable value — the physical entropy. Surprisingly, the simple conversion they used was valid for all the systems studied.” The researchers are currently expanding the application of their methodology to a wide and varied selection of systems. “Since we started working and talking about our work, we have been approached by many researchers from very different fields, asking us to help them calculate entropy from their data,” concludes Prof. Beck. “For now, we are concentrating on simulation of protein folding, a timely and urgent topic that can benefit tremendously from our discovery.”

TAU study among top 12 most important in the world

Making the future accessible

TAU study finds widespread misinterpretation of gene expression data

Fibroblasts involved in healing spur tumor growth in cancer

Bringing water to Tanzania