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TAU makes schizophrenia diagnosis easier with AI

TAU Computer Science master’s student Vered Zilberstein applies machine learning to identify schizophrenics

Tel Aviv University student, Vered Zilberstein, pursuing an MSc in Computer Science at the Blavatnik School of Computer Science, has co-led a study that will help detect schizophrenia patients using artificial intelligence.

She and her research partners applied a machine learning algorithm that identified which study participants were afflicted by schizophrenia and which were not.

 “We used participant scores in a language experiment to train a machine learning classifier to differentiate between schizophrenia patients and a control group of the same sex and age. It managed to do it at an 81.5% accuracy rate,” says Zilberstein, “This procedure is done through a sub-area called natural language processing.”

Collaborating with Beer Yaacov Mental Health Center, Zilberstein set out to explore how AI and computing can assist in the world of mental health – specifically in dealing with schizophrenia.

The disorder is very tricky to diagnose and is characterized by abnormal behavior, speech impairments and a diminished ability to understand reality.

Examples of thought and language disorders characterizing people with schizophrenia include jumping between unrelated issues, called “derailment,” while engaging in conversation. “Tangentiality” occurs when a sufferer replies to a question in an oblique and irrelevant manner. Grammatical mistakes and incoherent, illogical speech are also among the symptoms.

“However,” says Zilberstein, “you need to be very skilled to succeed in identifying speech difficulties affecting schizophrenia sufferers as well as those affecting other groups, such as people on the autistic spectrum.”

Zilberstein’s study included two experiments which examined two types of thought disorders. One focused on derailment, which is dissociative weakness. “It means that one is jumping from one subject to another during a conversation,” explains Zilberstein, “for example, someone can say: ‘I’ve always liked geography. My last teacher in that subject was Prof. August A. He was a man with black eyes. I also like black eyes. There are blue and grey eyes and other sorts too…’ and so on. You can clearly see that they jump very quickly between subjects and by the end of the sentence they have completely derailed from the initial topic, which was geography.”

The other experiment focused on incoherence caused by peculiar vocabulary and incorrect grammar. It is hard to understand what is meant. For example: “Oh, it was superb, you know, the trains broke, and the pond fell in the front doorway.”

Both experiments utilized interviews, questionnaires and photo descriptions. They involved 24 male patients affected by schizophrenia aged 30-40 and 27 mentally healthy males, serving as a control group.

The test results showed that, predictably, the control group tended to maintain focus on the conversation topics whereas the patients were more inclined to changing the subject. More important, it was the machine learning algorithm that could analyze and identify who was whom.

As a computer science master’s student, who comes from the world of exact sciences, what draws you to the world of mental health?

“I wanted to be involved in a combination of disciplines, and not only computer science. I wanted to write a thesis based on real data.”

How widespread, if at all, is the intertwining of artificial intelligence and mental health?

“While artificial intelligence gathers pace in the academic, industrial, educational and social media worlds, combining computer science and mental health is still very much in its infancy. However, artificial intelligence is inevitably going to affect almost all aspects of our lives.

“My study examined the way patients and healthy people talk but further studies may explore and compare between the way patients and healthy people write, for example on social media, which is what I intend on looking into in my research going forward.”

New Pulsed Electric Field Technology Could Allow for Less Invasive Tumor Molecular Profiling

Electroporation bears less of the negative consequences of biopsies, say TAU, IDC, Technion researcher Current cancer treatment courses often begin with tissue biopsies. Biopsies, however, which involve the physical resection of a small tissue sample, can lead to localized tissue injury, bleeding, inflammation, and stress, as well as increased risk of metastasis. New technology developed by a team of researchers from Tel Aviv University (TAU), Herzliya Interdisciplinary (IDC), and Technion–Israel Institute of Technology may soon offer an alternative means of profiling tissues. The research finds that electroporation — the application of high voltage pulsed electric fields to tissues — enables minimally invasive extraction of RNA and proteins that reveal tissue-specific differential expression critical to molecular profiling. “Our new method can enhance the information surgeons obtain from biopsy, for example,” explains Prof. Alexander Golberg of TAU’s Porter School of Environment and Earth Sciences, a lead author of the study. “By harvesting molecules from suspicious areas, this method enables improved diagnostics of the site and produces information pertinent to treatment decisions, including molecular biomarkers.” Research for the study was conducted by TAU graduate student Julia Sheviryov, Dr. Oz Solomon of IDC, Leon Anavy of the Technion, and Prof Zohar Yakhini from IDC and the Technion. The research was published in Scientific Reports on October 31. By extracting tissue-specific molecules using a combination of high-voltage and short pulses applied to specific sites, the technology enables profiling RNA, proteins, or metabolites in tissue and tissue environments. This can improve the accuracy of tumor diagnostics, including the potential response to different therapies. For the research, the scientists used electroporation to extract proteins and RNA from several normal human tissues, including liver tissues, and from a liver cancer model in mice. They then used advanced bioinformatics tools to demonstrate that tissue types can be distinguished by identifying specific molecules in the extracted samples. “Further in vivo development of extraction methods based on electroporation can drive novel approaches to the molecular profiling of tumors and tumor environments, and thereby to related diagnosis practices,” Prof. Golberg concludes. “Now we have a new method with which to sample tissue in vivo. We can sample molecules without extracting cells and without the risky excision of tissue parts.” The researchers now plan to develop a device for local extraction, thus enabling tumor heterogeneity mapping and the in vivo probing of tumor environment molecular composition.

TAU hosts first ever AI Week

Over 3,000 people are expected to attend the event, which begins this Sunday, November 17th

For the first time ever, Tel Aviv University will be hosting AI Week – an international forum for discussing the hottest topics in artificial intelligence. The event will take place from November 17th to the 21st and bring together technology experts, industry leaders, business executives, government representatives and a variety of other sectors. AI Week will be comprised of two main conference days with keynote speakers, ten tracks covering key topics in the field, as well as an innovation exhibition led by the Israel Airport Authority and satellite events. In addition, the event will include workshops, led by some of the top experts on artificial intelligence. The week will conclude with a hackathon focusing on utilizing AI for social good: healthcare, education, preserving the environment, and more. The purpose of AI Week is to discuss diverse topics related to or making use of artificial intelligence, including medicine, transportation, computer innovation, startups and social issues.  Alongside the lectures, there will be an exhibition of research posters and a presentation of the leading companies in the field. The keynote speakers will include Prof. Amnon Shashua, President and CEO of Mobileye; Prof. Isaac Ben-Israel, Director of the Blavatnik Interdisciplinary Cyber Research Center; Aharon Aharon, CEO of the Israel Innovation Authority; Dr. Kira Radinsky, CTO and Chairman of Diagnostic Robotics Technologies; Dr. Ben Lorica, Chief Data Scientist at O’Reilly Media and more.

Study shows Europeans migrated to the Levant 40,000 years ago

Discovery of teeth in Manot Cave sheds light on a population known for its cultural contributions, TAU researchers say
Who exactly were the Aurignacians, who lived in the Levant 40,000 years ago? Researchers from Tel Aviv University, the Israel Antiquities Authority, and Ben-Gurion University now report that these culturally sophisticated yet mysterious humans migrated from Europe to the Levant some 40,000 years ago, shedding light on a significant era in the region’s history. The Aurignacian culture first appeared in Europe some 43,000 years ago and is known for having produced bone tools, artifacts, jewelry, musical instruments, and cave paintings. For years, researchers believed that modern man’s entry into Europe led to the rapid decline of the Neanderthals, either through violent confrontation or wresting control of food sources. But recent genetic studies have shown that Neanderthals did not vanish. Instead, they assimilated into modern human immigrant populations. The new study adds further evidence to substantiate this theory. Through cutting-edge dental research on six human teeth discovered at Manot Cave in the Western Galilee, Dr. Rachel Sarig of TAU’s Goldschleger School of Dental Medicine, Dan David Center for Human Evolution and Biohistory Research and Shmunis Family Anthropology Institute in collaboration with Dr. Omry Barzilai of the Israel Antiquities Authority and colleagues in Austria and the United States, have demonstrated that Aurignacians arrived in modern-day Israel from Europe some 40,000 years ago — and that these Aurignacians comprised Neanderthals and Homo sapiens alike.

Teeth stand the test of time

“Unlike bones, teeth are preserved well because they’re made of enamel, the substance in the human body most resistant to the effects of time,” Dr. Sarig explains. “The structure, shape, and topography or surface bumps of the teeth provided important genetic information. We were able to use the external and internal shape of the teeth found in the cave to associate them with typical hominin groups: Neanderthal and Homo sapiens.” The researchers performed in-depth lab tests using micro-CT scans and 3D analyses on four of the teeth. The results surprised the researchers: Two teeth showed a typical morphology for Homo sapiens; one tooth showed features characteristic of Neanderthals; the last tooth showed a combination of Neanderthal and Homo sapiens features. This combination of Neanderthal and modern human features has, to date, been found only in European populations from the early Paleolithic period, suggesting their common origin.

A first-of-its-kind discovery

“Following the migration of European populations into this region, a new culture existed in the Levant for a short time, approximately 2,000-3,000 years. It then disappeared for no apparent reason,” adds Dr. Sarig. “Now we know something about their makeup.” “Until now, we hadn’t found any human remains with valid dating from this period in Israel,” adds Prof. Israel Hershkovitz, head of the Dan David Center, “so the group remains a mystery. This groundbreaking study contributes to the story of the population responsible for some of the world’s most important cultural contributions.”

Food for thought

Solving the climate crisis may start with what’s on your plate

By 2023, 8 billion people are expected to be living on Earth, and we’ll all be facing a serious challenge: how to feed everyone. We spoke with some of the experts at Tel Aviv University about how our choice of what to put on our plates can affect the rainforests on the other end of the globe.

Humanity in crisis

The idea of food security is that every person has the right to receive and obtain enough food to sustain them in good health over time. But even today, our planet is already struggling to keep up with demand, and we keep hearing reports of damage and depletion of basic resources like fresh water, usable territory, and energy. So how will we feed 9 billion people, a decade from now? “The food security crisis is considered a global problem,” explains Prof. Nir Ohad, head of the Manna Center for Food Safety and Security at Tel Aviv University. “In many parts of the world, the three basic conditions for food security do not exist: availability, production and accessibility. We’ve also had periods of austerity in Israel, where store shelves were empty and products were rationed. Today, thankfully, the situation is different, but take a country like Venezuela, which is rich in resources, but today is facing an economic collapse and suffering from severe problems related to food.”

What causes a crisis of this magnitude? According to Dr. Hagit Ulanovsky, from the Porter School of Environmental Studies, an expert on environmental and health risk management and one of the founders of the Israeli Forum for Sustainable Nutrition, there are many reasons: “Efficient agriculture requires environmental resources: soil, water, sunlight, fertilizer and more. But it doesn’t end there. The food production process doesn’t stop there, there’s also transporting the food and marketing it, which requires many additional resources. All of this adversely affects the environment: destroying the rainforests, soil erosion, pollution of the environment with excess fertilizers and pesticides, using up a lot of water, and greenhouse gas emissions in significant quantities, just like the industrial, transport or energy sectors.”

Recently, the headlines were dominated by huge fires in the Amazon rainforests, considered the “green lung of the Earth,” caused largely by the world’s growing demand for meat. Extensive forest areas were destroyed to make room for cattle. “The environmental cost of raising animals for food is huge,” explains Dr. Ulanovsky. What’s even more sad is that it’s not worthwhile. The high environmental cost is due to low ‘conversion efficiency’. For example: for every 100 calories the chicken eats, we will get about 15 calories in the egg it lays. For every 100 calories a cow eats, we only get about 3 calories! Where did the rest of the energy go? To sustain the life processes of a cow: breathing, digestion, movement, etc. Conversely, if we grow on the same soil and with the same amount of water food that is suitable for humans instead of animal feed – then we can eat 100 calories of that food and… actually get 100 calories.”

Stop now, before it runs out. The process of burning rainforest for the benefit of raising cattle.

Stop now, before it runs out. The process of burning rainforest for the benefit of raising cattle. 

Dr. Ulanovsky continues: “In light of increasing climate change, and in response to the worsening environmental pollution worldwide and especially in Israel, concerns about food insecurity are rising not only at the individual level, but also at the national level: extreme weather events will damage agricultural produce, soil and water. Pollution will seep into the vegetables we eat, new plant diseases will attack the fields and orchards. Disaster on the other side of the world will greatly affect our food security here, because most of the food we eat is imported from overseas, and therefore a reduction in production in Argentina or Ukraine will not only raise prices but may prevent food exports to Israel,” she concludes.

This is how the vicious cycle works: meat consumption in Israel is driving demand, which is accelerating the process of growing and production in distant countries like Argentina and Australia, and the environmental cost of the meat industry is rising. So how do we get out of the loop? One of the solutions offered by Prof. Ohad and Dr. Ulanovsky in their courses at Tel Aviv University is a shift to a sustainable diet.

 There's not enough for everyone. Empty food bowls in areas in a country in crisis.

 There’s not enough for everyone. Empty food bowls in areas in a country in crisis. 

The solution: less meat

The first thing people can do is make smart dietary choices. “Each of us has the ability to make a positive impact on the Israeli and even the global food system,” explains Dr. Ulanovsky. “We need to do all we can to preserve environmental resources, to enable continued healthy food production. This is especially important in the dense and small state of Israel, where the birth rate is particularly high. Israel is recognized worldwide as the startup nation, but not everyone knows that it is also the world leader in the most up-to-date nutrition guidelines, both health-wise and environmentally.”

Dr. Ulanovsky’s recommendation is to start with a simple step – to choose what to put in the kitchen and the dish you’re making. “This choice has a lot of power and the ability to make a difference. The new nutrition guidelines issued by the Ministry of Health in Israel include health considerations, and also present the environmental aspects of our dietary choices,” she says.

It turns out that health and environmental protection are overlapping concerns when it comes to culinary choices. “There are different approaches to determining a healthy diet, and the most well-tailored for our region is the Mediterranean diet, recommended by the Ministry of Health, where you eat lots of fruits and vegetables and add dairy and meat products in a balanced way,” Prof. Ohad says. “Vegetarian and vegan diets, which maintain the same nutritional balance of meat, dairy and egg substitutes, also help maintain a healthy lifestyle, sustainable agriculture and the environment. These diets are taking up ever-increasing space, which is a good thing.”

A healthy diet that also helps the environment - a diet rich in vegetables, fruits and legumes

A healthy diet that also helps the environment – a diet rich in vegetables, fruits and legumes

“Veganism is the best diet for the environment, and it is suitable and healthy for most people, although it is recommended to get professional nutritional advice in the process of transitioning to it,” Dr. Ulanovsky explains, adding, “However, many people find it difficult to give up animal products, and not everyone can make the change. But if each of us starts small and makes a gradual change, together we can make a difference to our planet.”

TAU grad’s short film sold to HBO

Atara Frish’s “The Love Letter”, produced at the Steve Tisch School of Film and Television, was purchased for broadcast by HBO Europe.

“The Love Letter” is a 19-minute-long film that deals with a complex relationship between two female soldiers in the Israel Defense Forces, a novice soldier and her direct superior. The relationship between the two ranges from romantic attraction to standard military bureaucracy. Noa (Gili Beit Hallahmi), a dedicated commander of new recruits in the IDF, receives a mysterious love letter from one of her female underlings. Suspecting that the letter is fake, she’s forced to choose between adhering to strict military protocol and giving in to her desire to feel loved, if only for a moment.

The film had its world premiere at the Tribeca Festival’s Short Film Competition, where it received special notice in the “Student Vision” category. The film also won the top prize at the Jerusalem Festival’s Short Film Competition, and was screened at Palm Springs Festival in the U.S. and many other international film festivals around the world.

“The Love Letter” was produced as part of the “Heroine” project, where five female directors created a short film each, which was then combined into one full-length feature. The project was produced at the Steve Tisch School of Film and Television, under the artistic direction of Michal Winnick and Mia Dreyfus, and produced by Efrat Cohen (Gaudamus Productions), and screened around the world.

Atara Frish is currently working on a TV series based on “The Love Letter”, as well as writing a full-length script for a feature film.

Mmm Mmm Marrow?

Study Finds Prehistoric Humans Ate Bone Marrow Like Canned Soup 400,000 Years Ago

Bone and skin preserved the nutritious marrow for later consumption, TAU researchers say Tel Aviv University researchers, in collaboration with scholars from Spain, have uncovered evidence of the storage and delayed consumption of animal bone marrow at Qesem Cave near Tel Aviv, the site of many major discoveries from the late Lower Paleolithic period some 400,000 years ago. The research provides direct evidence that early Paleolithic people saved animal bones for up to nine weeks before feasting on them inside Qesem Cave. The study, which was published in the October 9 issue of Science Advances, was led by Dr. Ruth Blasco of TAU’s Department of Archaeology and Ancient Near Eastern Civilizations and Centro Nacional de Investigación Sobre la Evolución Humana (CENIEH) and her TAU colleagues Prof. Ran Barkai and Prof. Avi Gopher. It was conducted in collaboration with Profs. Jordi Rosell and Maite Arilla of Universitat Rovira i Virgili (URV) and Institut Català de Paleoecologia Humana i Evolució Social (IPHES); Prof. Antoni Margalida of University of Lleida, University of Bern, and the Institute for Game and Wildlife Research (IREC); and Prof. Daniel Villalba of University of Lleida. “Bone marrow constitutes a significant source of nutrition and as such was long featured in the prehistoric diet,” explains Prof. Barkai. “Until now, evidence has pointed to immediate consumption of marrow following the procurement and removal of soft tissues. In our paper, we present evidence of storage and delayed consumption of bone marrow at Qesem Cave.” “This is the earliest evidence of such behavior and offers insight into the socioeconomics of the humans who lived at Qesem,” adds Dr. Blasco. “It also marks a threshold for new modes of Paleolithic human adaptation.” “Prehistoric humans brought to the cave selected body parts of the hunted animal carcasses,” explains Prof. Rosell. “The most common prey was fallow deer, and limbs and skulls were brought to the cave while the rest of the carcass was stripped of meat and fat at the hunting scene and left there. We found that the deer leg bones, specifically the metapodials, exhibited unique chopping marks on the shafts, which are not characteristic of the marks left from stripping fresh skin to fracture the bone and extract the marrow.” The researchers contend that the deer metapodials were kept at the cave covered in skin to facilitate the preservation of marrow for consumption in time of need. The researchers evaluated the preservation of bone marrow using an experimental series on deer, controlling exposure time and environmental parameters, combined with chemical analyses. The combination of archaeological and experimental results allowed them to isolate the specific marks linked to dry skin removal and determine a low rate of marrow fat degradation of up to nine weeks of exposure. “We discovered that preserving the bone along with the skin, for a period that could last for many weeks, enabled early humans to break the bone when necessary and eat the still nutritious bone marrow,” adds Dr. Blasco. “The bones were used as ‘cans’ that preserved the bone marrow for a long period until it was time to take off the dry skin, shatter the bone and eat the marrow,” Prof. Barkai emphasizes. Until recently, it was believed that the Paleolithic people were hunter gatherers who lived hand-to-mouth (the Stone Age version of farm-to-table), consuming whatever they caught that day and enduring long periods of hunger when food sources were scarce. “We show for the first time in our study that 420,000 to 200,000 years ago, prehistoric humans at Qesem Cave were sophisticated enough, intelligent enough and talented enough to know that it was possible to preserve particular bones of animals under specific conditions, and, when necessary, remove the skin, crack the bone and eat the bone marrow,” Prof. Gopher explains. According to the research, this is the earliest evidence in the world of food preservation and delayed consumption of food. This discovery joins other evidence of innovative behaviors found in Qesem Cave including recycling, the regular use of fire, and cooking and roasting meat. “We assume that all this was because elephants, previously a major source of food for humans, were no longer available, so the prehistoric humans in our region had to develop and invent new ways of living,” concludes Prof. Barkai. “This kind of behavior allowed humans to evolve and enter into a far more sophisticated kind of socioeconomic existence.” Photo caption: Marrow inside a metapodial bone after six weeks of storage. Credit: Dr. Ruth Blasco.  

TAU researchers develop new treatment for rare genetic disorder

Adolescents and young adults with familial adenomatous polyposis bear a high risk of developing cancer

Researchers from Tel Aviv University and Tel Aviv Sourasky Medical Center (Ichilov Hospital) have developed an innovative drug treatment for familial adenomatous polyposis (FAP), a rare, inherited condition that affects adolescents and young adults and often leads to colorectal cancer. The novel drug, based on antibiotics, inhibits the development of intestinal polyps that, left untreated, become cancerous. In a preliminary clinical trial, the condition of seven out of eight patients who completed the full treatment improved dramatically. The research was jointly led by Prof. Rina Rosin-Arbesfeld of the Department of Microbiology and Clinical Immunology at TAU’s Sackler School of Medicine and Prof. Revital Kariv of the Sackler School and the Department of Gastroenterology at Tel Aviv Sourasky Medical Center. FAP, which is characterized by multiple polyps along the gastrointestinal tract, especially in the large bowel, is caused by a mutation in the adenomatous polyposis coli (APC) gene. These mutations are also crucial for colorectal cancer development.

Why does FAP lead to colon cancer?

“To prevent the development of colorectal cancer, FAP patients are closely monitored via frequent colonoscopies to locate and remove their polyps,” Prof. Rosin-Arbesfeld says. “However, some patients must have their colons removed at a very young age, which dramatically affects their quality of life.” In its normal state, APC promotes the production of a protein that inhibits cancer development. But mutations to the APC gene produce an inactive protein that is unable to prevent the development of the polyps. In some FAP patients, the mutations in the APC gene are what are called “nonsense mutations.” “Each sequence of three nucleotides in the DNA is a code that tells the cell to produce a certain amino acid, which are the building blocks of the proteins produced in the body’s cells,” Prof. Rosin-Arbesfeld explains. “At the end of the protein coding sequence, there is usually a ‘stop codon’ to stop the protein production. But in FAP patients with a nonsense mutation, the APC’s stop codon appears prematurely, so the protein production stops prematurely, creating an inactive protein.”

Preventing surgical intervention

Previous experiments on cell cultures and mouse models in Prof. Rosin-Arbesfeld’s laboratory revealed that certain types of antibiotics caused cells to “ignore” the mutation stop codon and a normal protein resulted. These trials yielded promising results that led to the clinical trial at Tel Aviv Sourasky Medical Center. “Since the relevant antibiotics were already approved for human use, we decided to move directly from the laboratory to the clinic and to examine the treatment of FAP patients,” says Prof. Rosin-Arbesfeld. In the clinical study carried out by Prof. Kariv and Dr. Shlomi Cohen, director of the Pediatric Gastroenterology Unit at Dana-Dwek Children’s Hospital, 10 FAP patients received the novel antibiotic therapy. Eight of them completed the treatment, which lasted four months. Colonoscopies performed during and after the treatment showed that in seven patients the polyps significantly decreased in number. Moreover, the positive effects of the treatment were evident a year after it began. “Our goal as therapists, in addition to preventing cancer, is to improve the quality of life of our patients and their families and to enable them to live as full and normal lives as possible,” Prof. Kariv concludes. “The new therapeutic approach we are developing may allow patients to delay surgical intervention or even prevent it entirely.” The researchers recently won Tel Aviv University’s SPARK grant, which supports the development of applied research.

A better way to kill tumor cells

Engineered cells may be harnessed in new immunotherapy for cancer patients, Tel Aviv University researchers say

There is now a multitude of therapies to treat cancer, from chemotherapy and radiation to immunotherapy and small molecule inhibitors. Chemotherapy is still the most widely used cancer treatment, but chemotherapy attacks all the rapidly dividing cells that it locates within the body, whether they’re ultimately harmful or beneficial. A new Tel Aviv University study led by Dr. Yaron Carmi of TAU’s Sackler Faculty of Medicine finds that a form of immunotherapy used to treat the blood cancer leukemia may be effective in treating other kinds of cancer as well. A form of leukemic immunotherapy known as chimeric antigen receptors (CAR) T-cell therapy may also be effective in killing solid tumor cells coated in specific antibodies, the researchers say. The study was published in the Journal of Clinical Investigation on August 26.

Using the body’s own immune system

“Chemotherapy damages all fast-growing cells, including hair follicles and cells that line the gastrointestinal tract, and this attack on healthy cells causes serious side effects, which include hair loss, nausea, mood changes, pain, anaemia, nerve and muscle problems, and kidney issues,” explains Dr. Carmi. “Immunotherapy, on the other hand, is a type of biological therapy that uses the body’s own immune system to seek out and destroy cancer cells. Engineered T cells have been proven very successful in treating blood cancer but attempts to use them to fight solid cancers have been disappointing. “Our engineered cells have now shown efficacy in attacking solid tumors as well,” Dr. Carmi says. CAR T-cell therapy is a form of immunotherapy that uses altered T cells to fight cancer. T cells are a type of lymphocyte, or white blood cell, that plays a central role in the immune response. T cells are collected from the patient and modified in the lab to produce structures called CARs on their surface. These receptors allow the T cells to attach to a specific antigen on the tumor cells and kill them.

Fewer side effects, more precision

Side effects from immunotherapy may include severe inflammation, caused by an overactive immune system working to fight tumor cells. “Patients who utilize CAR T-cell therapy experience significantly fewer side effects than with chemotherapy,” adds Dr. Carmi. “And while chemotherapy is only effective while the drug is in the body, immunotherapy provides long-lasting protection against cancer. “Our lab discovered a distinct subset of helper T cells, also known as CD4+ T cells, that express the high-affinity receptor for IgG – an antibody – and efficiently kill tumor cells coated with these antibodies,” explains Dr. Carmi. “This method uses CAR T-cell therapy and combines it with antibody specificity. Based on this discovery we were able to engineer novel T cells with enhanced tumor-killing activity and higher specificity, compared with other T cell-based therapies for cancer. “Our engineered cells have the potential to overcome barriers usually faced by CAR T-cell therapy and have shown efficacy in solid tumors. This finding has the capability to change the way cancer is treated, demonstrating that the immune system can be utilized to identify and fight all types of cancer.”

TAU launches new center for quantum science & tech

The center will bring together twenty labs from across campus and offer academic programs as well as promote international ties

Tel Aviv University is proud to launch a new Center for Quantum Science and Technology, announced during the research workshop “From Quantum Computing to Quantum Chemistry.”
According to Tel Aviv University Rector, Prof. Yaron Oz: “The quantum revolution is knocking on our door, and many people expect it to be just as great and significant as the industrial and digital revolutions, completely transforming our technology and way of life,”
Prof. Oz also added that “Quantum theory, first developed more than a century ago, deals with phenomena at the level of tiny particles such as electrons and photons. Many quantum phenomena contradict human intuition and our experience in day to day reality.
“Leading TAU scientists, like Prof. Yakir Aharonov, have contributed significantly to our understanding of these phenomena. Applied quantum research is a relatively new field that is rapidly gaining momentum both in Israel and worldwide, and this is the right time to put considerable effort into it.”

Twenty labs from different disciplines

The new Center for Quantum Science and Technology is expected to bring together about twenty research labs from different faculties across campus, from a diverse array of scientific disciplines.
The Center will combine three main purposes: academic programs in relevant tracks such as quantum computing and quantum communication, designed to attract the best young minds to this innovative field, research activities based on TAU’s multidisciplinary nature, enabling collaborations between researchers from many different disciplines: computing, materials, sensors, chemistry, physics and mathematics, and later also economics, business and more.
It will also work forming international ties with research centers and business corporations – including giants like Google, IBM and Microsoft, who are developing quantum technologies, alongside potential consumers (like the financial sector), who must prepare for the advent of quantum computing.
The Center will also recruit new faculty members, organize conferences and workshops, and offer scholarships and fellowships for students.

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