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New blood test could detect genetic disorders during first trimester

Test could map the fetal genome and detect innumerable diseases caused by minuscule impairments, Tel Aviv University researchers say

Tel Aviv University researchers have developed a new blood test for genetic disorders that may allow parents to learn about the health of their baby as early as 11 weeks into pregnancy.

The simple blood test lets doctors diagnose genetic disorders in fetuses early in pregnancy by sequencing small amounts of DNA in the mother’s and the father’s blood. A computer algorithm harnessing the results of the sequencing would then produce a “map” of the fetal genome, predicting mutations with 99% or better accuracy depending on the mutation type.

Prof. Noam Shomron of TAU’s Sackler School of Medicine led the research, which was conducted by TAU graduate student Tom Rabinowitz with Avital Polsky, Artem Danilevsky, Guy Shapira and Chen Raff, all from Prof. Shomron’s lab. The study is a collaboration with Dr. David Golan of the Technion-Israel Institute of Technology and Prof. Lina Basel-Salmon and Dr. Reut Tomashov-Matar of Rabin Medical Center. It was published on February 20 in the journal Genome Research.

A safe and simple procedure

“Noninvasive prenatal tests are already available for chromosome disorders such as Down syndrome,” Prof. Shomron says. “Our new procedure is based on fetal DNA fragments that circulate freely in maternal blood and bears only a minimal risk for the mother and fetus compared with such invasive techniques as the amniotic fluid test. We will now be able to identify numerous mutations and diseases in a safe and simple procedure available at the doctor’s office.

“The genetic mechanism behind Down syndrome affects a very large portion of the genome and therefore is easier to detect,” Prof. Shomron explains. “We performed upgraded noninvasive fetal genotyping, using a novel approach and an improved algorithm, to detect many other diseases that are caused by smaller parts of the genome. This is like looking at a map of the world and noticing not only that a continent is missing, but also that a single house is missing.

“The practical applications are endless: a single blood test that would detect a wide range of genetic diseases, such as Tay-Sachs disease, cystic fibrosis and many others.”

An algorithm for DNA

Prof. Shomron and colleagues tested blood samples from three families at Rabin Medical Center in the 11th week of gestation. They extracted maternal and paternal DNA from their white blood cells and fetal DNA from a placental cell sample. They also extracted circulating cell-free fetal DNA from the maternal blood.

“We sequenced all these DNA samples and created a computer algorithm that utilizes the parental DNA as well as the cell-free fetal DNA to reconstruct the fetal genome and predict mutations,” says Prof. Shomron. “We compared our predictions to the true fetal DNA originating from the placenta. Our model is the first to predict small inherited insertions and deletions. The method described can serve as a general framework for noninvasive prenatal diagnoses.”

The researchers are working on further improving the accuracy of the method and extending it to detect even more types of mutations.

 

 

TAU scholar named Knight of the Order of Arts and Letters

Dr. Sefy Hendler received the highest decoration awarded by the French Ministry of Culture

Dr. Sefy Hendler, head of the Department of Art History at Tel Aviv University, has been named Knight of the Order of Arts and Letters, one of the highest decorations awarded by the French Ministry of Culture. The title was given to him for “his commitment to the service of French culture”.

He received the decoration from the hands of the French Ambassador to Israel, Mrs. Hélène Le Gal, during a ceremony that took place on February 18, at the French Embassy in Tel Aviv.

“I think that in our country, fed by American culture, there is room for other voices,” he said. “The French voice, according to which I have been educated for many years, is among the most important, especially because it is different, and I wish that my students, as well as the other people who come to the University, will be exposed to this aspect of culture “.

Personalities who received this award in the past include British poet and playwright T. S. Eliot, Bob Dylan, David Bowie, American writer Paul Auster, actress Sharon Stone, as well as Israeli authors Amos Oz, David Grossman, Ohad Naharin, Haim Gouri et Zeruya Shalev.

TAU Confers Honorary Doctorate on Pioneer in Internet Technology

Prof. Amnon Yariv honored for decades of breakthrough research in optoelectronics

In recognition of his indelible mark in the field of integrated optics technology, Tel Aviv University awarded an honorary doctorate to Prof. Amnon Yariv, the Martin and Eileen Summerfield Professor of Applied Physics and Electrical Engineering at the California Institute of Technology (CalTech). The conferment ceremony was held at the Raya and Joseph Jaglom Auditorium in the George S. Wise Senate Building. Prof. Yariv is a member of and visiting lecturer at TAU’s Mortimer and Raymond Sackler Institute of Advanced Studies.

With a plethora of awards and honors, including the prestigious National Medal of Science presented by President Barak Obama in 2010, Prof. Yariv is widely credited with transforming the optical communications industry. His research group, which focuses on the theoretical and technological underpinning of optical communication, has generated numerous technologies, not the least of which was the invention of the semiconductor distributed feedback laser. This device enabled the transmission of mass data via phone, video, cable and the Internet, which has profoundly influenced society and culture across the globe.

Israeli-born Prof. Yariv fought in Israel’s War of Independence from 1948-1950, before leaving for the US. He completed his BSc, MSc and PhD in electrical engineering at the University of California, Berkeley, taking on his first role as Research Associate there in 1958. He then spent five years on the technical staff of Bell Telephone Laboratories, before returning to academia in 1964 as a professor of electrical engineering at CalTech, where he remains today.

In his tribute to Prof. Yariv, TAU Rector Yaron Oz spoke of how TAU awards honorary doctorates to those who are visionaries in their field — to those who create new realities instead of merely improving on what exists. “The ability to set a vision far beyond imagination and bridge the gap between vision and reality, this is the paths of excellence that led you here today,” said Prof. Oz.

Presenting the award along with Prof. Oz was TAU Vice President Raanan Rein. Among the guests in attendance were: Prof. Yossi Rosenwaks, Dean of the Iby and Aladar Fleischman Faculty of Engineering; Prof. Avraham Gover, Head, Israeli Free Electron Laser Knowledge Center for Radiation Sources and Applications, Faculty of Engineering;  and Prof. (Emeritus) Emanuel Marom, former Dean of Engineering.

Featured image: From left: Prof. Yaron Oz, Prof. Amnon Yariv and Prof. Raanan Rein Photo: Yehonatan Zur

Adolescents with Celiac disease at higher risk of eating disorders

Teenage girls who are overweight and have Celiac Disease are at highest risk of developing eating disorders

Celiac disease is a chronic condition, characterized by inflammation and atrophy of the small intestine. It affects roughly 1 in 100 people, and a strict, lifelong gluten-free diet is the only remedy. A new Tel Aviv University study finds a link between the disaese and a higher incidence of disordered eating behavior during adolescence and young adulthood.

The researchers found that 19% of female teens and 7% of male teens with CD exhibited eating disorders, compared to 8% and 4% of adolescents who did not have CD. Disordered eating behaviors affect about 10% of adolescents and refer to a wide range of abnormal eating behaviors, including binge eating, dieting, skipping meals regularly, self-induced vomiting and obsessive calorie counting. These behaviors are most common among older, overweight female adolescents with CD.

The study was led by Dr. Itay Tokatly-Latzer of TAU’s Sackler Faculty of Medicine and the Department of Pediatrics at Chaim Sheba Medical Center. It was overseen by Dr. Orit Pinhas-Hamiel and conducted by Dr. Daniel Stein, Dr. Batia Weiss and Prof. Liat Lerner-Geva, all of TAU’s Sackler Faculty of Medicine. The results were published in Eating and Weight Disorders.

Early warning signs are crucial

“We discovered an increased occurrence of disordered eating behavior among adolescents with CD,” Dr. Tokatly-Latzer says. “Caregivers of Celiac patients should be aware of the possibility of them having eating disorders. Early recognition of this can prevent the deterioration of these states into full-blown disorders such as anorexia nervosa and bulimia.

“These eating patterns can lead to a failure to meet nutritional and metabolic needs, which cause severe impairment to psychosocial functioning,” Dr. Tokatly-Latzer continues. “Primary care physicians and gastroenterologists who encounter adolescents with CD should increase their awareness to the possibility of this population having disordered eating behavior. Once the suspicion is raised, they can refer them for psychological and nutritional treatment.”

The researchers conducted a web-mediated survey on 136 adolescents aged 12-18 with CD. The survey assessed the participants’ rate of disordered eating behavior as well as their adherence to a gluten-free diet. The survey, conducted over the course of a year, included two self-rating questionnaires: the Eating Attitudes Test-26 and the gluten-free diet questionnaire. Only 32% of the participants reported a strict adherence to a gluten-free diet.

What medical teams should watch for

“Eating disorders have a perplexing etiology that includes biological, sociological, psychological and environmental elements,” Dr. Tokatly-Latzer explains. “Not only does the excessive preoccupation with food increase the likelihood of individuals with Celiac to develop eating disorders, but there is a major aspect that involves food limitation of any kind that probably triggers a predisposition for developing pathological eating tendencies.

“This study should raise awareness for medical teams to the importance of closely monitoring adolescents with CD for disordered eating behavior, especially when they are female, overweight or older. Since individuals with disordered eating behavior are at increased risk of developing a clinical form of an eating disorder, early identification and intervention may improve therapeutic outcomes.”

MIT expert helps promote synthetic biology at TAU

Prof. Christopher Voigt of MIT visits TAU to talk to researchers and set up new collaborations for grad students

Living organisms are amazing feats of engineering: By following instructions encoded entirely in DNA, living systems can sense and respond to their environment, build intricate structures and materials, and churn out complex chemicals. How these abilities are encoded is undeniably complicated, but figuring out how to embrace this complexity is at the heart of synthetic-biology.

Dr. Johann Elbaz, an Assistant Professor at Tel Aviv University’s Department of Molecular Microbiology and Biotechnology, organized the first professional visit to Israel of  Prof. Christopher Voigt, MIT biological engineer and co-director of MIT’s Synthetic Biology Center. Located in Cambridge, Massachusetts, the Voigt lab is taking on the enormous task of designing, fabricating, and testing large sequences of DNA—20,000 bases long and more-at never-before-seen scales. It’s created software that automates the design of DNA circuits for living cells.  The aim is to help people who are not skilled biologists to quickly design working biological systems.

 

Chris Voigt (Forth person from left) and Johann Elbaz (Fifth person from left) with the iGEM team at TAU at Tel Aviv University

Prof. Voigt gave an impressive talk at Tel Aviv University as a special seminar at the School of Molecular Cell Biology and Biotechnology, attended by researchers and students from different parts of the TAU campus as well as other universities. Prof. Voigt was a special guest of Dr. Elbaz, who came to help accelerate the development of synthetic biology in Israel, both academic and industrial.

During the visit, a collaboration was initiated between the Elbaz lab, a synthetic biology lab that specializes in applications within living nanomaterials and living sensors, and the center at MIT. This collaboration envisions the acceleration of graduate student exchange between MIT and at TAU, while further developing the field of synthetic biology in Israel.

The “equipped kitchen” approach to biology

“The grand vision of the Synthetic Biology is to tie everything together: the design, the building, and the testing,” Elbaz says. “Rather than refining a recipe over many years by preparing one dish at a time, a better approach is to equip a kitchen capable of making thousands of different recipes simultaneously, each with slightly different ingredients, cooking times, or other alterations. This allows for the study of the entire set together, to find common aspects between the best and worst results as a means of arriving at the perfect recipe. Such capability will accelerate the development of unique applications such as molecules and materials, extending what we can do through pure chemistry to smart agriculture and medicine that sense their environments and proceed accordingly to repair damage.”

All of these sound like far reaching applications. Could we really use synthetic biology to engineer living organisms? “Ultimately, we want to be able to design living systems at a complexity and a level of sophistication that we know is possible but we just don’t have the capability to do yet,” Elbaz concludes.

Featured image: Johann Elbaz (left) and Chris Voigt (right) in Jerusalem

Are two brains better than one?

In scientific research, sometimes 1 + 1 equals more than 2

What do scientists need to become a winning team? Is it true that the opposites attracts? Or is it that research based on a rivalry brings about the best results? Let’s look at some of the famous scientist pairings that, if they’d hadn’t known of each other, might not have given the world their amazing discoveries, ideas, and inventions that have changed our lives profoundly.

Didn’t go with the flow

Thomas Alva Addison and Nicola Tesla were both great inventors of the 19th century, who brought about revolutionary technological changes and made our modern life possible. Tesla was a talented physicist and electrical engineer who emigrated from the Austro-Hungarian Empire to the United States and was nicknamed the “Wizard of the West.” He found his first job with businessman Edison, known as “The Inventor from Menlo Park”. The two collaborated to promote the use of electrical systems, and after a while parted in anger after Tesla claimed that he had not received the promised compensation for his work.

A few years later, when Edison tried to market his electric bulb, he also developed an electric grid based on direct current and competed for the opportunity to build a power plant that would supply electricity to the entire eastern coast of the United States. Tesla, who developed the alternating current with industrialist George Westinghouse, thus became a direct rival of Edison, not to mention his enemy, overnight.

“So began one of the most powerful technological wars mankind has ever known – the war of currents,” says Prof. David Mandelowitz of the School of Electrical Engineering at the, Iby and Aladar Fleischmann Faculty of Engineering at Tel Aviv University. “When Tesla joined George Westinghouse, this war went beyond the technological aspect and also spread to the realm of commerce.”

Edison tried to brand the invention of his rival as a tool of murder, more suitable to executions in the electric chair than household appliances, but the move didn’t succeed. The war of the currents between the two ended when Edison was at a disadvantage, and the Tesla power station successfully supplied electricity to the entire East Coast. “In 1893, when the President of the United States activated the main lighting fixture in the city of Chicago, the victory of Tesla and Westinghouse was determined,” says Prof. Mandelowitz. “The rivalry between Tesla and Edison is now a parable for a pair of researchers whose technological dispute became a personal and economic war, which shocked the global research community.”

While working together, they promoted the invention of the Dynamo, invented by Edison, but it seems that when they worked against each other, they worked harder, causing us all to benefit. From the straight current we get batteries, and from alternating current – household and industrial power consumption. Both kinds of current benefit fans of heavy metal rock bands, especially the band AC/DC, who are named after the sign that symbolizes both types of currents and appears on electrical installations.

Philosophy, love, religion and Zionism

No screenwriter could think of more interesting plot twists than those of Hannah Arendt, one of the most important political philosophers of the 20th century. Her work and life were influenced by her ambivalent relationship with the State of Israel, with Zionism and with her married lecturer Martin Heidegger, who later became her lover and an activist in the Nazi regime.

Arendt met Heidegger as a young student, when he was already an admired professor, who was married, at the University of Marburg in Germany. A passionate romance developed between the two, interrupted by the Nazis’ rise to power in 1933, when Arendt left Germany. “Martin Heidegger is, in the eyes of many, one of the great German philosophers or great philosophers in the twentieth century,” says Prof. Joseph Schwartz, head of the School of Philosophy, Linguistics and Science Studies at the Lester and Sally Entin Faculty of Humanities. “At the same time, he’s a very controversial philosopher, both because of his work and, in particular, because of his active involvement in the Nazi regime. Hannah Arendt, also one of the great philosophers of the twentieth century, mostly acquired that status after World War II when she lived in America, to which she had to emigrate when she fled Germany after the Nazis came to power.”

Arendt never hid her Jewishness and was arrested because of her opposition to the right-wing regime in her homeland, and later lost her German citizenship. On the one hand, she was a political activist and investigated anti-Semitism in Germany, was considered close to Jewish intellectuals and promoted immigration to Israel, and on the other hand she didn’t turn her back on those who favored the murder of her people. She had a complex relationship with the State of Israel, which became particularly tense in light of her review of the Eichmann trial and the publication of her controversial book “Eichmann in Jerusalem – A Report on the Banality of Evil.”

The connection between Arendt and Heidegger resumed at the end of the war. “In the coming decades, Arendt is going to significantly advance Heidegger’s thought in English and in the United States, and there is no doubt that she helped raise his status internationally, and that impact still holds to this day. The letters the two exchanged were published and translated into Hebrew, and beyond gossip about the relationship between a professor and a student – they contain mainly fascinating philosophical discourse between two great philosophers, who saw themselves as philosophers first.”

Over the years, in the various articles Ardent published in the field of existential philosophy, she referred to Heidegger’s views, and even if she criticized them, she never denounced him. Heidegger’s diaries from the period of World War II (“The Black Notebooks”) were recently published, and they only emphasize how Nazi ideology combined with his philosophy. Arendt’s conduct regarding the identity of the State of Israel and Heidegger has raised heated debates in academia and beyond.

A combination of factors that led to the Nobel Prize

The fascinating pair of researchers Maria Skolodawska from Poland (later Marie Curie) and Frenchman Pierre Curie’s passion for mathematics, physics and chemistry came from their individual passions. Each of them established his position in the field of physical and chemical phenomena, but the combination of their forces in the research on radiation and radioactivity led to a joint win of the Nobel Prize in Physics.

As a woman, Maria had to work harder. Many doors were closed to her in her native Poland during her years of developing a career as a gifted physicist and chemist, which began at the end of the 19th century. But it seems that all of this only made the young Marie a pioneer in many ways: she completed two degrees in chemistry and physics at the Sorbonne in Paris after her request to study at the Polish University was rejected due to the political inclinations of her family. She was the first woman to teach in this respectable institution after she was appointed professor of physics. She also broke the glass ceiling as the first woman to win the Nobel Prize, and did it again eight years later when she won it again, this time in chemistry. In fact, she is one of the only two people in history to have won the prestigious award in two different fields.

When they met, Pierre Curie was an instructor at the School of Physics and Chemistry in Paris, and Maria Skolodawska was a young scientist. “Pierre’s achievements in his doctoral work (magnetism, pyroelectricity, piezoelectricity) gave him a very distinguished name, along with his brother Jacques, who contributed to the study,” says Dr. Israel Hayim Shek of the Raymond and Beverly Sackler Faculty of Exact Sciences. “Marie (who changed her name when she emigrated to France) becomes Pierre’s assistant in his lab and soon became a full partner in laboratory research and theoretical work.” The two found a great common interest in the study of radioactive materials, and their discoveries brought them together both professionally and personally. They married in a secular ceremony and devoted their lives to the study of radioactive materials.

“A great expertise in chemistry and physics, along with a sharp, analytical perspective, and a lot of dirty work and determination go into their discoveries, in the face of frustrations, disappointments, a lack of budgets, a shaky economic situation. But they invest everything into science,” Dr. Shek says. In 1898, after years of refining uranium ore, they identified two new chemical elements.

The first is called Polonium, named after Mary’s homeland, and the second is Radium, named after the Latin word “radius”, meaning “ray of light,” as it glows in the dark. In the same year their first daughter, Irina, is born. In 1904, a year after receiving the Nobel Prize, their second daughter, Eva, was born, and the Curies raised their two daughters on informal education, exposing them to the principle science and scientific research, along with things like learning Chinese, sculpture, self-expression and play.

In 1903 they, along with Henri Beckerle, received the Nobel Prize in Physics for their research, and in 1911 Marie again won the prestigious award, this time in the field of chemistry, in recognition of the discovery of these two elements.

“One of the questions people tend to ask is whether Marie Curie would have been able to achieve her great success without her husband’s help, or would Pierre have succeeded in finding his discoveries without Marie as an assistant? It’s difficult, of course, to answer conclusively. But there is no doubt that beyond the romanticized aspects (a foreign woman, poverty, marriage, hard work under pressure), the joint work of the couple pushed them both forward, far beyond what might have happened if they had not cooperated, and had it not been for the mutual respect that they felt for each other,” says Dr. Shek and concludes “Perhaps without Pierre’s recognition of Mary’s great abilities and uncompromising push, her work would not have been possible in the atmosphere of the conservative society at that time.”

It is believed that Mary paid for her many years of research. She died at the age of 66 from a pre-leukemic syndrome caused by her exposure to these dangerous substances for many years. Pierre had been killed earlier in a fatal car accident, in their tenth year of marriage, when Marie was accepted as a full professor at the Sorbonne. The pair of researchers was immortalized by the scientific community. The unit measuring radioactivity used to be named “curie” in their honor, as was the radioactive element curium.

 

A match made in Megiddo

How the chemistry between archaeology and physics researchers led to groundbreaking discoveries about biblical history

Sometimes when you’ve stopped looking for a solution is exactly when it pops up. Israel Finkelstein, Jacob M. Alkow Professor of the Archaeology of Israel in the Bronze and Iron Ages, Sonia and Marco Nadler Institute of Archaeology, discovered a very interesting finding in 1998, at the archaeological excavation of Megiddo. He noticed a dig participant who did not quite fit the profile of a typical university undergraduate. 

“I sniffed around and learned that this particular student was actually a TAU professor flying under the radar. He turned out to be a very important ‘find,’” smiles Finkelstein. That student, incumbent of the Wolfson Chair in Experimental Physics Eli Piasetzky, Raymond and Beverly Sackler Faculty of Exact Sciences, was pursuing a degree in archaeology. Prof. Finkelstein pulled him aside to talk, and so began a research partnership that is still active two decades later.  

When were early Biblical texts written?

The archaeological issue of the day was mapping the chronology of the Iron Age in ancient Israel. Finkelstein challenged Piasetzky to improve the dating of remains from biblical times by using the radiocarbon method. The findings, published in professional and lay publications worldwide, rendered a new timeline of ancient Israel with lasting ramifications for biblical studies.

“Until then, the dating of texts was based on Biblical considerations,” explains Prof. Finkelstein, adding, “You can say that Biblical history was the path of the researchers, and archeology was used as a tool to prove the Bible stories were true.” He said. His article caused an uproar among researchers around the world, and he realized that he needed a more accurate dating tool and a talented mathematician to help him. Prof. Finkelstein presented his friend with a challenge – to accurately date the findings discovered in the excavations and to prove his claims.

Using the radiocarbon dating method on hundreds of items collected and tested, Prof. Piasetzky and Prof. Finkelstein presented a new and more accurate timeline in the history of ancient Israel, which was published in the New York Times, and had long-term implications for the study of the Biblical period since then.

 

The excavation site at Tel Megiddo, where it all began

Algorithms for reading ancient inscriptions

Prof. Piasetzky and Prof. Finkelstein continue their quest to reconstruct ancient history. As reported by The New York Times, they are conducting analyses to help better decipher ink inscriptions on potsherds, known as ostraca that were unearthed at an ancient fortress in the deep desert of Arad in southern Israel.

“The citadel of Arad stands like a time capsule: Active about 2,600 years ago, it was a relatively short-lived, godforsaken outpost, a five-day journey from Jerusalem, populated by maybe 30 soldiers,” describes Finkelstein. “Who inscribed the potsherds found there? Who read them? The ostraca teach us about government and about literacy in ancient Judah. If we determine when writing became a tool used by a wide swathe of society, we can shed light on when early Biblical texts were written.”

A shopping list from thousands of years ago

Prof. Piasetzky and Prof. Finkelstein have put together a team of archaeologists, historians, physicists, mathematicians, and computer scientists to analyze handwriting and determine just how many hands penned the Arad ostraca.

To do so, they employ physics techniques of multispectral imaging to reveal inscriptions and improve readability. Next, they compare handwriting by using algorithms specially developed by the team. What they found there was surprising: the new lines discovered were a letter requesting the issuance of wine and food from the warehouses of the Tel Arad fortress to one of the military units in the area. The recipient of the letter was the warehouse clerk, while the address was an officer from Beersheba.

Beyond the information about what people used to eat and drink during that time, the researchers revealed that even quartermasters knew how to read and write, and also learned a few new words that don’t appear in the Bible. “From the content of the letters we learn that literacy permeated even the low ranks of the military administration of the kingdom. If we extrapolate this data to other areas of Judea, and assume that this was the case in the civil administration and among the clergy, the level of literacy is considerable. This level of literacy is a reasonable background for the composition of Biblical texts,” explains Prof. Finkelstein.

Facing the future

After studying the past, Prof. Finkelstein and Prof. Piasetzky explain what can be done with these special technologies in the 2000s. “One may ask why a student of mathematics would be interested in developing tools for handwriting analysis of ancient inscriptions,” Prof. Piasetzky says. “But this type of analysis is also acutely needed today by, say, lawyers, banks, and the police. Furthermore, we’re finding solutions for the challenges of deciphering ink inscriptions found on uneven clay surfaces with faded markings and missing pieces. If our algorithms can analyze decayed inscriptions, think what they can do with modern-day handwriting on flat clean paper surfaces.”

Prof. Finkelstein adds: “With handwriting we face a problem of subjectivity. Scholars – all of us – come with preconceptions. We can convince ourselves that we see this or that particular letter. The computer does not have preconceptions. It measures length of strokes and angles, making numerical comparisons. Our next step is to integrate multispectral imaging at digs. This could dramatically improve excavation methodologies by determining on site if a potsherd is treasure or junk. One inscription can change the way we understand history.”

Featured image: Prof. Eli Piasetzky and Prof. Israel Finkelstein talk about how it all started

Inside a bat’s brain

Prof. Yaniv Assaf and Prof. Yossi Yovel are working together on a unique collection of brain scans of different mammals

It’s a chicken versus egg scenario: Does behavior build a neural network or does the design of a brain network dictate behavior? It turns out that they both influence each other.

“Evolutionary science holds that particular behaviors drives the brain to develop and evolve in a particular way. Later, brain networks may drive behavior,” explains Prof. Yossi Yovel of the Department of Zoology, George S. Wise Faculty of Life Sciences. Yovel specializes in bat echolocation – the location of objects by reflected sound – at his Bat Lab of Neuro-Ecology. 

A number of years ago he approached his former MSc advisor, Prof. Yaniv Assaf, Head of the Department of Neurobiology, with a surprising request. Yovel sought to draw on Assaf’s expertise in MRI imaging techniques to scan the brains of wild bats. Could the images show how bats’ use of sound rather than vision to navigate the world influences the development of their neural networks? “I focus on human brain imaging,” says Assaf. “Now, five years later, we have scanned over 100 species – all expired of natural causes – including many species of bats, of course,” Assaf continues with a nod to Yovel. “We use the MRI machine after hours so as not to interfere with ongoing research, and we have found that, yes, bat brain networks have highly developed aural – rather than visual – networks.”

From bats to all mamals

What began as a scientific hobby has become a scientific first. The scans, which are specially calibrated to show the design and function of brain microstructure, pathways, and networks, reveal the principles governing the mammalian brain.

“Like the internet and other computer networks, or road and transportation systems, the brain is a network. The brain’s two hemispheres are connected with fibers. Our scans show that mammals with a greater number of inter-hemisphere connecting fibers will have, inversely, poorer connectivity within the hemisphere itself and vice-versa,” says Assaf. “This information can influence how networks are constructed.”

The true story of the autistic man who inspired the film Rain Man illustrates this phenomenon: The hemispheres of his brain were completely unconnected. The local network in each hemisphere was so strong that he could perform complex computations within seconds. But the lack of connection between hemispheres affected his function and behavior. We need a mix of both for a functional, strong network.

Access for researchers worldwide

”While evolutionary scientists are certainly interested in our scans, it is mathematicians and computer scientists working on smart, efficient computer networks and artificial intelligence who are the most excited,” says Assaf.

Yovel continues, “When people hear about our project at conferences or by word of mouth, they immediately want to see our findings. But we are not yet ready. We aim to scan 10% of all mammals, which means about 500 species including those transported from abroad, which will be very costly. We need graduate students to help build the collection more quickly. We aim to create the only collection of its kind worldwide – a digital collection of scans at the Steinhardt Museum of Natural History that can be accessed by scientists around the world.”

Featured image: Prof. Yossi Yovel and Prof. Yaniv Assaf 

Conversations in the Clean Room

At the shared laboratories of the Center for Nanoscience and Nanotechnology, casual conversations between scientists can lead to breakthroughs

A chemist and a physicist walk into a clean room. No, this is not the one about how many people it takes to change a light bulb. Nor is it the one about two Israelis and three opinions. This is a true story about how two doctoral students from different fields got talking and realized that they may be able to use chemistry to solve a nagging problem in physics. “These students were the best kind – curious and open to new ideas and different ways of approaching a problem,” says Prof. Gil Markovich of the Raymond and Beverly Sackler School of Chemistry. Prof. Yoram Dagan, Raymond and Beverly Sackler School of Physics and Astronomy, nods in agreement.

Markovich and Dagan were the students’ respective PhD advisors and quickly saw the benefit of collaborating. In their research, they sought a solution to prevent damage to the surface of semiconductors – small components that control electrical current in devices such as computers and mobile phones, which damage the functioning of the devices.

For this kind of research, a particularly sterile laboratory is required. The special conditions in the “clean room” include a constant temperature of 20 degrees, 50 percent humidity, and a very powerful filter that prevents the entry of dust particles into the laboratory space and is responsible for creating a sterile work environment. These conditions are essential for the production of certain materials, especially electronic chips, which can be disrupted by something as tiny as a grain of dust.

From cell phones to thermal cameras  

The scientists are using a chemical rather than physical process to create an electrical insulating thin film the thickness of a single atom. According to Dagan, “Unlike in physics, where non-organic materials are used, we used organic compounds to get the components that create the atom-thick layer.” In the process carried out by the scientists, they heated organic compounds to the point of dissolution. Once they touch the surface, they receive additional energy and break down until the process stops on its own. “This creates only a single layer of the insulating material, because there is not enough energy to form another layer,” Dagan explains. “In a cheap and rapid chemical process, we were able to offer an alternative to complicated and costly processes, and even to achieve a better result.”

Their invention could improve microelectronics in all the devices we carry in our pockets and have in our homes by making them faster, more efficient and more compact. “This is a long-term project – an idea that may be implementable twenty years down the line. Yet exploring this basic physics problem using nano-chemistry led us to an application that can be realized today,” says Dagan.

Markovich and Dagan have teamed up with industry experts for guidance in applying their technology to improve resolution in infrared cameras used for defense and security installations. The Israel Innovation Authority (formerly the Office of the Chief Scientist) has invested in the project with a grant reserved solely for projects that have a good chance to be commercialized in Israel. “It all begins, though, with basic science. Basic science is the foundation of knowledge. When we discover new possibilities and new materials, applications can grow,” stresses Dagan.

Collaboration opens new possibilities

Markovich and Dagan share a passion for unlocking the secrets of the universe: “We are both interested in origins,” says Dagan. “Gil researches the interaction of minerals with amino acids and DNA – the original building blocks of life.  I am interested in the fundamental properties of matter and materials. I would not think up chemical approaches to physical problems by myself. Our collaboration is opening up new possibilities.” says Dagan.

“This has been a fun ride,” adds Markovich. “First, Yoram is a nice person. And I never worked on these kinds of problems before. We have ideas for cooperation on chemical ways to create new materials for quantum computing. The future is wide open.” 

Featured iage:Prof. Gil Markovich and Prof. Yoram Dagan (Photo: Yoram Reshef)

Gala Advances TAU-Austria Medical Cooperation

The Austrian Friends’ celebrate the continuing success of collaborative projects between TAU and Medical University of Vienna

Following their first gala event in November 2017, Tel Aviv University’s Austrian Friends and the Medical University of Vienna (MU) hosted their second gala dinner in Vienna, helping to raise funds for joint research projects between the two institutions. With over 200 guests in attendance, the gala celebrated the successful cooperation between TAU’s Sackler Faculty of Medicine and MU.

Dr. Bernhard Ramsauer, President of Austrian Friends, spoke of how TAU is at the heart of the Israeli high-tech innovation sector, and how it has steadily grown in stature. “This is reflected in the growing number of cooperation projects with leading academic institutions around the world,” he noted.  TAU Vice President Prof Raanan Rein also stressed the importance of international cooperation, mentioning some of TAU’s successful cooperation agreements.  

Prof.  Markus Müller, Rector of MU, and Prof. Wolf-Dieter Baumgartner, also of MU, told the audience about the longstanding collaboration with researchers at TAU decades prior to the official cooperation agreement signed in 2017, collaboration that had already yielded successful findings in medical research and clinical practice.  

Prof. Liat Kishon-Rabin, of the Department of Communication Disorders and Head of the Stanley Steyer School of Health Professions, gave a lecture on “Nourishing the Brain from Infancy with Hearing and Language Interaction.”

featured:From left: Prof. Markus Müller; Prof. Liat Kishon-Rabin; Dr. Bernhard Ramsauer; Dr. Christiane Druml, Director of the Medical Collections, MU; Prof. Wolf-Dieter Baumgartner; Prof. Raanan Rein; Alexander Gertner, General Secretary of TAU’s Austrian Friends 

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