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New genetically encoded sensor isolates hidden Leukemic cells

Cells express surface markers that help them escape most targeted therapies, Tel Aviv University researchers say

Understanding how leukemic stem cells are regulated has become an important area of cancer research. All stem cells can multiply, proliferate and differentiate. Because of these qualities, leukemic stem cells are the most malignant of all leukemic cells. 

A team of Tel Aviv University researchers have now devised a novel biosensor that can isolate and target leukemic stem cells. The research team, led by Dr. Michael Milyavsky of the Department of Pathology at TAU’s Sackler School of Medicine, discuss their unique genetically encoded sensor and its ability to identify, isolate and characterize leukemic stem cells in a study published on January 31 in Leukemia.

Raising the survival rate for blood cancers

“The major reason for the dismal survival rate in blood cancers is the inherent resistance of leukemic stem cells to therapy,” Dr. Milyavsky says. “But only a minor fraction of leukemic cells have high regenerative potential, and it is this regeneration that results in disease relapse. A lack of tools to specifically isolate leukemic stem cells has precluded the comprehensive study and specific targeting of these stem cells until now.”

Until recently, cancer researchers used markers on the surface of the cell to distinguish leukemic stem cells from the bulk of cancer cells, with only limited success. “There are hidden cancer stem cells that express differentiated surface markers despite their stem cell function. This permits those cells to escape targeted therapies,” Dr. Milyavsky explains. “By labeling leukemia cells on the basis of their stem character alone, our sensor manages to overcome surface marker-based issues.

“We believe that our biosensor can provide a prototype for precision oncology efforts to target patient-specific leukemic stem cells to fight this deadly disease.”

Personalized medical testing

The scientists searched genomic databases for “enhancers,” the specific regulatory regions of the genome that are particularly active in stem cells. Then they harnessed genome engineering to develop a sensor composed of a stem cell active enhancer fused with a fluorescence gene that labels the cells in which the enhancer is active.

The scientists were also able to demonstrate that sensor-positive leukemia stem cells are sensitive to a known and inexpensive cancer drug called 4-HPR (fenretinide), providing a novel biomarker for patients who can potentially benefit from this drug.

“Using this sensor, we can perform personalized medicine oriented to drug screens by barcoding a patient’s own leukemia cells to find the best combination of drugs that will be able to target both leukemia in bulk as well as leukemia stem cells inside it,” Dr. Milyavsky concludes. “We’re also interested in developing killer genes that will eradicate specific leukemia stem cells in which our sensor is active.”

The researchers are now investigating those genes that are active in leukemic stem cells in the hope finding druggable targets.

When Harry met Zahava

TAU expert on post-military combat trauma, Prof. Zahava Solomon, speaks at the Veterans’ Mental Health Conference in London

TAU’s Prof. Zahava Solomon discussed issues relating to the long term trauma of military combatants with HRM Prince Harry, the Duke of Sussex, at the 2019 Veterans’ Mental Health Conference held at King’s College London. Prof. Solomon was one of a select number of international experts on trauma who presented at the conference. The participants’ goal was to share ideas about how best to support the psychological wellbeing of former military personnel.

The Duke, who served two tours in Afghanistan, discussed the long-term effects of military service with several speakers, praising their work. He is a regular champion of mental health advocacy through his work with the Royal Foundation’s ‘Heads Together’ project, which aims to promote a national conversation on the topic.

Solomon spoke with Prince Harry about the findings of her study that she presented and mainly about the psychological effects of participating in combat – not only on the mental health of the combatants themselves but also on their families. The Prince expressed great interest and concern for the safety of soldiers.

Prof. Zahava Solomon​

“I expressed my appreciation and admiration in the name of mental health professionals inIsrael for his involvement and sensitivity, both because of his social standing and also because of his past as a combatant,” said Solomon, an Israel Prize laureate and a retired Lieutenant-Colonel in the Israel Defense Forces. “He said he could relate to the challenges based on his own experience. For someone in his position to come forward and say it’s quite normal to be traumatized, is really beneficial.”​

​In an interview with Forces TV, Solomon said: “For many veterans, the war starts when the shooting stops. Even 20 years after the war, we have actually observed the trauma – both psychological and physical – being suffered by the traumatized combatants. And on top of that, there are individuals who did not initially succumb to stress on the battlefield, but later on, over a period of 20 years, have actually developed late onset post-traumatic stress disorder.”

Prof. Solomon heads the I-CORE Research Center for Mass Trauma at Tel Aviv University. Formerly, she held roles as Head of Research in Mental Health in the IDF Medical Corps, Head of TAU’s Bob Shapell School of Social Work, and Head of TAU’s Adler Research Center for Child Welfare and Protection. She has published over 400 academic articles and seven books. Her studies of trauma among combat veterans, prisoners of war and Holocaust survivors spans over four decades and are unparalleled in scope, depth and breath. Her work helps shape the psychosocial treatment and rehabilitation of traumatized soldiers and their families.

Featured image: Prince Harry, the Duke of Sussex discusses post-military combat trauma. Credit: Daniel Leightley/Dan Dyball

A unique collaboration for Blockchain Applications at the Coller School of Management

This is a special opportunity for researchers at the Coller School of Management and Tel Aviv University to carry out blockchain and crypto currency research in cooperation with international industry.

The blockchain technology enables secure business activity on the internet and commercial undertakings between various parties, without the necessity for a central managerial entity – this managerial function being replaced by encrypted blocks of information.  A few months ago the Coller School of Management at Tel Aviv University established the first venture of this kind in Israel – the Hogeg Institute for Blockchain Applications, with the aim of advancing research, teaching and distribution of information in the area of blockchain technology.

As part of the activities of the Institute, a unique collaboration was created when the the Hogeg Institute for Blockchain Applications signed an agreement with the Frankfurt School Blockchain Center to support academic research in the area of blockchain technology and crypto currencies.  The project is being financed by Accelerator Frankfurt GmbH, which leads the Fintech/Blockchain area in Germany and focuses its activities on introducing the digital B2B technologies into the financial sector, in cooperation with Santiment Deutschland, a well-known success story in the area of crypto currencies that provides access to a unique platform for storing data and enables its use for academic research.

Dr Jacob Mendel, Managing Director of the Hogeg Institute for Blockchain Applications explains:  “This is a groundbreaking venture in academic cooperation to advance blockchain research focusing on providing economic and business solutions that will contribute to activity on the cutting edge of international research in which a number of institutions at leading universities throughout the world such as Stanford and Columbia participate.”

Maria Pennanen, CEO of Santiment Deutschland, adds:  “We want to get students and researchers together to analyze and understand the crypto currency market data.  As a first stage, the cooperation will focus on academic work.  We will hold the first academic event in the crypto area, under the title ‘Academia Meets the Market Players’, where we will present our initial findings.”

Ram Shoham, founder of Accelerator Frankfurt:  “It is an honor for us to start this cooperation with the Hogeg Institute for Blockchain Applications.  We believe in caring for the global blockchain eco-system through cooperative ventures and partnerships.”

Prof. Dan Amiram, Associate Dean of the Coller School of Management at Tel Aviv University and Head of the Hogeg Institute for Blockchain Applications:  “This is a special opportunity for researchers from Tel Aviv University to carry out projects in cooperation with international industry that contends with new challenges and applies the technology in a range of areas of activity.”

Our very best wishes go to the students and researchers at Tel Aviv University and the Coller School of Management who are participating in this special research project in the blockchain and crypto-currency area in cooperation with international industry.

What’s in a pi?

March 14h is International Pi Day. Why do we celebrate it? Is pi still relevant 4,000 years after being discovered? And is peach pie better than cherry?

What’s the best kind of pie? And what’s the perfect crust-to-filling ratio? Mankind has been struggling with these questions since the dawn of baked goods, which is probably about as long as the number pi has been known to us.

Although Pi Day was first celebrated in the 1980s, the number pi (represented as the Greek letter π) was first discovered about 4,000 years ago. The ratio of a circle’s circumference to the circle’s diameter, pi is always the same, whether you’re measuring a penny or a truck tire. Not only that, but pi is an “irrational” number – no matter how many digits of pi we calculate, we’ll never be able to predict which digit comes next. 

We decided to ask Ofir Gorodetsy, a PhD student at the School of Mathematical Sciences at Tel Aviv University, about the significance of pi.

“The decimal expansion of π starts with 3.14,” Ofir said. “Which is why we celebrate Pi Day on March 14th every year. And aside from being known to Ancient Egyptians and Babylonians, pi is also mentioned in the Hebrew Bible, where the approximation 3 is used to measure the circumference of a circle.”

Too much pi?

Although most people are familiar with pi as being 3.14, mathematicians have been struggling to find the other digits of pi for centuries. According to Ofir, “figuring out the digits of pi gets pretty difficult after a dozen or so. Many scholars from all over the world have tried to find more and more digits: Archimedes, Liu Hui, Brahmagupta, Fibonacci, Isaac Newton. In the 18th century a mathematician even came up with proof that the digits of pi don’t follow any pattern, so they never repeat in any predictable way.”

According to Ofir, figuring out the digits of pi is much easier these days. Even freshmen at university can calculate as many digits as they’d like, using modern tools.

But the magic of pi is not only its length, but how common it is in the natural world. The disk of the sun, the pupil of our eyes, the ripples in a pond, even the way rivers tend to bend and flow can be described using pi. It’s used in the work of biologists, engineers, geographers, physicsts, mathematicians. Almost every discipline that deals with the world around us crosses paths with this unique number at some point. 

So why do we celebrate Pi Day? Probably because math is at its most delicious when it’s fresh out of the oven.

New blood test could detect genetic disorders during first trimester

Test could map the fetal genome and detect innumerable diseases caused by minuscule impairments, Tel Aviv University researchers say

Tel Aviv University researchers have developed a new blood test for genetic disorders that may allow parents to learn about the health of their baby as early as 11 weeks into pregnancy.

The simple blood test lets doctors diagnose genetic disorders in fetuses early in pregnancy by sequencing small amounts of DNA in the mother’s and the father’s blood. A computer algorithm harnessing the results of the sequencing would then produce a “map” of the fetal genome, predicting mutations with 99% or better accuracy depending on the mutation type.

Prof. Noam Shomron of TAU’s Sackler School of Medicine led the research, which was conducted by TAU graduate student Tom Rabinowitz with Avital Polsky, Artem Danilevsky, Guy Shapira and Chen Raff, all from Prof. Shomron’s lab. The study is a collaboration with Dr. David Golan of the Technion-Israel Institute of Technology and Prof. Lina Basel-Salmon and Dr. Reut Tomashov-Matar of Rabin Medical Center. It was published on February 20 in the journal Genome Research.

A safe and simple procedure

“Noninvasive prenatal tests are already available for chromosome disorders such as Down syndrome,” Prof. Shomron says. “Our new procedure is based on fetal DNA fragments that circulate freely in maternal blood and bears only a minimal risk for the mother and fetus compared with such invasive techniques as the amniotic fluid test. We will now be able to identify numerous mutations and diseases in a safe and simple procedure available at the doctor’s office.

“The genetic mechanism behind Down syndrome affects a very large portion of the genome and therefore is easier to detect,” Prof. Shomron explains. “We performed upgraded noninvasive fetal genotyping, using a novel approach and an improved algorithm, to detect many other diseases that are caused by smaller parts of the genome. This is like looking at a map of the world and noticing not only that a continent is missing, but also that a single house is missing.

“The practical applications are endless: a single blood test that would detect a wide range of genetic diseases, such as Tay-Sachs disease, cystic fibrosis and many others.”

An algorithm for DNA

Prof. Shomron and colleagues tested blood samples from three families at Rabin Medical Center in the 11th week of gestation. They extracted maternal and paternal DNA from their white blood cells and fetal DNA from a placental cell sample. They also extracted circulating cell-free fetal DNA from the maternal blood.

“We sequenced all these DNA samples and created a computer algorithm that utilizes the parental DNA as well as the cell-free fetal DNA to reconstruct the fetal genome and predict mutations,” says Prof. Shomron. “We compared our predictions to the true fetal DNA originating from the placenta. Our model is the first to predict small inherited insertions and deletions. The method described can serve as a general framework for noninvasive prenatal diagnoses.”

The researchers are working on further improving the accuracy of the method and extending it to detect even more types of mutations.

 

 

TAU scholar named Knight of the Order of Arts and Letters

Dr. Sefy Hendler received the highest decoration awarded by the French Ministry of Culture

Dr. Sefy Hendler, head of the Department of Art History at Tel Aviv University, has been named Knight of the Order of Arts and Letters, one of the highest decorations awarded by the French Ministry of Culture. The title was given to him for “his commitment to the service of French culture”.

He received the decoration from the hands of the French Ambassador to Israel, Mrs. Hélène Le Gal, during a ceremony that took place on February 18, at the French Embassy in Tel Aviv.

“I think that in our country, fed by American culture, there is room for other voices,” he said. “The French voice, according to which I have been educated for many years, is among the most important, especially because it is different, and I wish that my students, as well as the other people who come to the University, will be exposed to this aspect of culture “.

Personalities who received this award in the past include British poet and playwright T. S. Eliot, Bob Dylan, David Bowie, American writer Paul Auster, actress Sharon Stone, as well as Israeli authors Amos Oz, David Grossman, Ohad Naharin, Haim Gouri et Zeruya Shalev.

TAU Confers Honorary Doctorate on Pioneer in Internet Technology

Prof. Amnon Yariv honored for decades of breakthrough research in optoelectronics

In recognition of his indelible mark in the field of integrated optics technology, Tel Aviv University awarded an honorary doctorate to Prof. Amnon Yariv, the Martin and Eileen Summerfield Professor of Applied Physics and Electrical Engineering at the California Institute of Technology (CalTech). The conferment ceremony was held at the Raya and Joseph Jaglom Auditorium in the George S. Wise Senate Building. Prof. Yariv is a member of and visiting lecturer at TAU’s Mortimer and Raymond Sackler Institute of Advanced Studies.

With a plethora of awards and honors, including the prestigious National Medal of Science presented by President Barak Obama in 2010, Prof. Yariv is widely credited with transforming the optical communications industry. His research group, which focuses on the theoretical and technological underpinning of optical communication, has generated numerous technologies, not the least of which was the invention of the semiconductor distributed feedback laser. This device enabled the transmission of mass data via phone, video, cable and the Internet, which has profoundly influenced society and culture across the globe.

Israeli-born Prof. Yariv fought in Israel’s War of Independence from 1948-1950, before leaving for the US. He completed his BSc, MSc and PhD in electrical engineering at the University of California, Berkeley, taking on his first role as Research Associate there in 1958. He then spent five years on the technical staff of Bell Telephone Laboratories, before returning to academia in 1964 as a professor of electrical engineering at CalTech, where he remains today.

In his tribute to Prof. Yariv, TAU Rector Yaron Oz spoke of how TAU awards honorary doctorates to those who are visionaries in their field — to those who create new realities instead of merely improving on what exists. “The ability to set a vision far beyond imagination and bridge the gap between vision and reality, this is the paths of excellence that led you here today,” said Prof. Oz.

Presenting the award along with Prof. Oz was TAU Vice President Raanan Rein. Among the guests in attendance were: Prof. Yossi Rosenwaks, Dean of the Iby and Aladar Fleischman Faculty of Engineering; Prof. Avraham Gover, Head, Israeli Free Electron Laser Knowledge Center for Radiation Sources and Applications, Faculty of Engineering;  and Prof. (Emeritus) Emanuel Marom, former Dean of Engineering.

Featured image: From left: Prof. Yaron Oz, Prof. Amnon Yariv and Prof. Raanan Rein Photo: Yehonatan Zur

Adolescents with Celiac disease at higher risk of eating disorders

Teenage girls who are overweight and have Celiac Disease are at highest risk of developing eating disorders

Celiac disease is a chronic condition, characterized by inflammation and atrophy of the small intestine. It affects roughly 1 in 100 people, and a strict, lifelong gluten-free diet is the only remedy. A new Tel Aviv University study finds a link between the disaese and a higher incidence of disordered eating behavior during adolescence and young adulthood.

The researchers found that 19% of female teens and 7% of male teens with CD exhibited eating disorders, compared to 8% and 4% of adolescents who did not have CD. Disordered eating behaviors affect about 10% of adolescents and refer to a wide range of abnormal eating behaviors, including binge eating, dieting, skipping meals regularly, self-induced vomiting and obsessive calorie counting. These behaviors are most common among older, overweight female adolescents with CD.

The study was led by Dr. Itay Tokatly-Latzer of TAU’s Sackler Faculty of Medicine and the Department of Pediatrics at Chaim Sheba Medical Center. It was overseen by Dr. Orit Pinhas-Hamiel and conducted by Dr. Daniel Stein, Dr. Batia Weiss and Prof. Liat Lerner-Geva, all of TAU’s Sackler Faculty of Medicine. The results were published in Eating and Weight Disorders.

Early warning signs are crucial

“We discovered an increased occurrence of disordered eating behavior among adolescents with CD,” Dr. Tokatly-Latzer says. “Caregivers of Celiac patients should be aware of the possibility of them having eating disorders. Early recognition of this can prevent the deterioration of these states into full-blown disorders such as anorexia nervosa and bulimia.

“These eating patterns can lead to a failure to meet nutritional and metabolic needs, which cause severe impairment to psychosocial functioning,” Dr. Tokatly-Latzer continues. “Primary care physicians and gastroenterologists who encounter adolescents with CD should increase their awareness to the possibility of this population having disordered eating behavior. Once the suspicion is raised, they can refer them for psychological and nutritional treatment.”

The researchers conducted a web-mediated survey on 136 adolescents aged 12-18 with CD. The survey assessed the participants’ rate of disordered eating behavior as well as their adherence to a gluten-free diet. The survey, conducted over the course of a year, included two self-rating questionnaires: the Eating Attitudes Test-26 and the gluten-free diet questionnaire. Only 32% of the participants reported a strict adherence to a gluten-free diet.

What medical teams should watch for

“Eating disorders have a perplexing etiology that includes biological, sociological, psychological and environmental elements,” Dr. Tokatly-Latzer explains. “Not only does the excessive preoccupation with food increase the likelihood of individuals with Celiac to develop eating disorders, but there is a major aspect that involves food limitation of any kind that probably triggers a predisposition for developing pathological eating tendencies.

“This study should raise awareness for medical teams to the importance of closely monitoring adolescents with CD for disordered eating behavior, especially when they are female, overweight or older. Since individuals with disordered eating behavior are at increased risk of developing a clinical form of an eating disorder, early identification and intervention may improve therapeutic outcomes.”

MIT expert helps promote synthetic biology at TAU

Prof. Christopher Voigt of MIT visits TAU to talk to researchers and set up new collaborations for grad students

Living organisms are amazing feats of engineering: By following instructions encoded entirely in DNA, living systems can sense and respond to their environment, build intricate structures and materials, and churn out complex chemicals. How these abilities are encoded is undeniably complicated, but figuring out how to embrace this complexity is at the heart of synthetic-biology.

Dr. Johann Elbaz, an Assistant Professor at Tel Aviv University’s Department of Molecular Microbiology and Biotechnology, organized the first professional visit to Israel of  Prof. Christopher Voigt, MIT biological engineer and co-director of MIT’s Synthetic Biology Center. Located in Cambridge, Massachusetts, the Voigt lab is taking on the enormous task of designing, fabricating, and testing large sequences of DNA—20,000 bases long and more-at never-before-seen scales. It’s created software that automates the design of DNA circuits for living cells.  The aim is to help people who are not skilled biologists to quickly design working biological systems.

 

Chris Voigt (Forth person from left) and Johann Elbaz (Fifth person from left) with the iGEM team at TAU at Tel Aviv University

Prof. Voigt gave an impressive talk at Tel Aviv University as a special seminar at the School of Molecular Cell Biology and Biotechnology, attended by researchers and students from different parts of the TAU campus as well as other universities. Prof. Voigt was a special guest of Dr. Elbaz, who came to help accelerate the development of synthetic biology in Israel, both academic and industrial.

During the visit, a collaboration was initiated between the Elbaz lab, a synthetic biology lab that specializes in applications within living nanomaterials and living sensors, and the center at MIT. This collaboration envisions the acceleration of graduate student exchange between MIT and at TAU, while further developing the field of synthetic biology in Israel.

The “equipped kitchen” approach to biology

“The grand vision of the Synthetic Biology is to tie everything together: the design, the building, and the testing,” Elbaz says. “Rather than refining a recipe over many years by preparing one dish at a time, a better approach is to equip a kitchen capable of making thousands of different recipes simultaneously, each with slightly different ingredients, cooking times, or other alterations. This allows for the study of the entire set together, to find common aspects between the best and worst results as a means of arriving at the perfect recipe. Such capability will accelerate the development of unique applications such as molecules and materials, extending what we can do through pure chemistry to smart agriculture and medicine that sense their environments and proceed accordingly to repair damage.”

All of these sound like far reaching applications. Could we really use synthetic biology to engineer living organisms? “Ultimately, we want to be able to design living systems at a complexity and a level of sophistication that we know is possible but we just don’t have the capability to do yet,” Elbaz concludes.

Featured image: Johann Elbaz (left) and Chris Voigt (right) in Jerusalem

Are two brains better than one?

In scientific research, sometimes 1 + 1 equals more than 2

What do scientists need to become a winning team? Is it true that the opposites attracts? Or is it that research based on a rivalry brings about the best results? Let’s look at some of the famous scientist pairings that, if they’d hadn’t known of each other, might not have given the world their amazing discoveries, ideas, and inventions that have changed our lives profoundly.

Didn’t go with the flow

Thomas Alva Addison and Nicola Tesla were both great inventors of the 19th century, who brought about revolutionary technological changes and made our modern life possible. Tesla was a talented physicist and electrical engineer who emigrated from the Austro-Hungarian Empire to the United States and was nicknamed the “Wizard of the West.” He found his first job with businessman Edison, known as “The Inventor from Menlo Park”. The two collaborated to promote the use of electrical systems, and after a while parted in anger after Tesla claimed that he had not received the promised compensation for his work.

A few years later, when Edison tried to market his electric bulb, he also developed an electric grid based on direct current and competed for the opportunity to build a power plant that would supply electricity to the entire eastern coast of the United States. Tesla, who developed the alternating current with industrialist George Westinghouse, thus became a direct rival of Edison, not to mention his enemy, overnight.

“So began one of the most powerful technological wars mankind has ever known – the war of currents,” says Prof. David Mandelowitz of the School of Electrical Engineering at the, Iby and Aladar Fleischmann Faculty of Engineering at Tel Aviv University. “When Tesla joined George Westinghouse, this war went beyond the technological aspect and also spread to the realm of commerce.”

Edison tried to brand the invention of his rival as a tool of murder, more suitable to executions in the electric chair than household appliances, but the move didn’t succeed. The war of the currents between the two ended when Edison was at a disadvantage, and the Tesla power station successfully supplied electricity to the entire East Coast. “In 1893, when the President of the United States activated the main lighting fixture in the city of Chicago, the victory of Tesla and Westinghouse was determined,” says Prof. Mandelowitz. “The rivalry between Tesla and Edison is now a parable for a pair of researchers whose technological dispute became a personal and economic war, which shocked the global research community.”

While working together, they promoted the invention of the Dynamo, invented by Edison, but it seems that when they worked against each other, they worked harder, causing us all to benefit. From the straight current we get batteries, and from alternating current – household and industrial power consumption. Both kinds of current benefit fans of heavy metal rock bands, especially the band AC/DC, who are named after the sign that symbolizes both types of currents and appears on electrical installations.

Philosophy, love, religion and Zionism

No screenwriter could think of more interesting plot twists than those of Hannah Arendt, one of the most important political philosophers of the 20th century. Her work and life were influenced by her ambivalent relationship with the State of Israel, with Zionism and with her married lecturer Martin Heidegger, who later became her lover and an activist in the Nazi regime.

Arendt met Heidegger as a young student, when he was already an admired professor, who was married, at the University of Marburg in Germany. A passionate romance developed between the two, interrupted by the Nazis’ rise to power in 1933, when Arendt left Germany. “Martin Heidegger is, in the eyes of many, one of the great German philosophers or great philosophers in the twentieth century,” says Prof. Joseph Schwartz, head of the School of Philosophy, Linguistics and Science Studies at the Lester and Sally Entin Faculty of Humanities. “At the same time, he’s a very controversial philosopher, both because of his work and, in particular, because of his active involvement in the Nazi regime. Hannah Arendt, also one of the great philosophers of the twentieth century, mostly acquired that status after World War II when she lived in America, to which she had to emigrate when she fled Germany after the Nazis came to power.”

Arendt never hid her Jewishness and was arrested because of her opposition to the right-wing regime in her homeland, and later lost her German citizenship. On the one hand, she was a political activist and investigated anti-Semitism in Germany, was considered close to Jewish intellectuals and promoted immigration to Israel, and on the other hand she didn’t turn her back on those who favored the murder of her people. She had a complex relationship with the State of Israel, which became particularly tense in light of her review of the Eichmann trial and the publication of her controversial book “Eichmann in Jerusalem – A Report on the Banality of Evil.”

The connection between Arendt and Heidegger resumed at the end of the war. “In the coming decades, Arendt is going to significantly advance Heidegger’s thought in English and in the United States, and there is no doubt that she helped raise his status internationally, and that impact still holds to this day. The letters the two exchanged were published and translated into Hebrew, and beyond gossip about the relationship between a professor and a student – they contain mainly fascinating philosophical discourse between two great philosophers, who saw themselves as philosophers first.”

Over the years, in the various articles Ardent published in the field of existential philosophy, she referred to Heidegger’s views, and even if she criticized them, she never denounced him. Heidegger’s diaries from the period of World War II (“The Black Notebooks”) were recently published, and they only emphasize how Nazi ideology combined with his philosophy. Arendt’s conduct regarding the identity of the State of Israel and Heidegger has raised heated debates in academia and beyond.

A combination of factors that led to the Nobel Prize

The fascinating pair of researchers Maria Skolodawska from Poland (later Marie Curie) and Frenchman Pierre Curie’s passion for mathematics, physics and chemistry came from their individual passions. Each of them established his position in the field of physical and chemical phenomena, but the combination of their forces in the research on radiation and radioactivity led to a joint win of the Nobel Prize in Physics.

As a woman, Maria had to work harder. Many doors were closed to her in her native Poland during her years of developing a career as a gifted physicist and chemist, which began at the end of the 19th century. But it seems that all of this only made the young Marie a pioneer in many ways: she completed two degrees in chemistry and physics at the Sorbonne in Paris after her request to study at the Polish University was rejected due to the political inclinations of her family. She was the first woman to teach in this respectable institution after she was appointed professor of physics. She also broke the glass ceiling as the first woman to win the Nobel Prize, and did it again eight years later when she won it again, this time in chemistry. In fact, she is one of the only two people in history to have won the prestigious award in two different fields.

When they met, Pierre Curie was an instructor at the School of Physics and Chemistry in Paris, and Maria Skolodawska was a young scientist. “Pierre’s achievements in his doctoral work (magnetism, pyroelectricity, piezoelectricity) gave him a very distinguished name, along with his brother Jacques, who contributed to the study,” says Dr. Israel Hayim Shek of the Raymond and Beverly Sackler Faculty of Exact Sciences. “Marie (who changed her name when she emigrated to France) becomes Pierre’s assistant in his lab and soon became a full partner in laboratory research and theoretical work.” The two found a great common interest in the study of radioactive materials, and their discoveries brought them together both professionally and personally. They married in a secular ceremony and devoted their lives to the study of radioactive materials.

“A great expertise in chemistry and physics, along with a sharp, analytical perspective, and a lot of dirty work and determination go into their discoveries, in the face of frustrations, disappointments, a lack of budgets, a shaky economic situation. But they invest everything into science,” Dr. Shek says. In 1898, after years of refining uranium ore, they identified two new chemical elements.

The first is called Polonium, named after Mary’s homeland, and the second is Radium, named after the Latin word “radius”, meaning “ray of light,” as it glows in the dark. In the same year their first daughter, Irina, is born. In 1904, a year after receiving the Nobel Prize, their second daughter, Eva, was born, and the Curies raised their two daughters on informal education, exposing them to the principle science and scientific research, along with things like learning Chinese, sculpture, self-expression and play.

In 1903 they, along with Henri Beckerle, received the Nobel Prize in Physics for their research, and in 1911 Marie again won the prestigious award, this time in the field of chemistry, in recognition of the discovery of these two elements.

“One of the questions people tend to ask is whether Marie Curie would have been able to achieve her great success without her husband’s help, or would Pierre have succeeded in finding his discoveries without Marie as an assistant? It’s difficult, of course, to answer conclusively. But there is no doubt that beyond the romanticized aspects (a foreign woman, poverty, marriage, hard work under pressure), the joint work of the couple pushed them both forward, far beyond what might have happened if they had not cooperated, and had it not been for the mutual respect that they felt for each other,” says Dr. Shek and concludes “Perhaps without Pierre’s recognition of Mary’s great abilities and uncompromising push, her work would not have been possible in the atmosphere of the conservative society at that time.”

It is believed that Mary paid for her many years of research. She died at the age of 66 from a pre-leukemic syndrome caused by her exposure to these dangerous substances for many years. Pierre had been killed earlier in a fatal car accident, in their tenth year of marriage, when Marie was accepted as a full professor at the Sorbonne. The pair of researchers was immortalized by the scientific community. The unit measuring radioactivity used to be named “curie” in their honor, as was the radioactive element curium.

 

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