New nanomedicines for mRNA therapeutics in breast cancer and heart failure

Written on |

The project has been awarded a total of 14.9 million EUR; Prof. Dan Peer is leading the mRNA targeting work package.

TAU researcher Prof. Dan Peer, from the school of Molecular Cell Biology and Biotechnology, is one of 11 partners in the international project EXPERT that has been awarded a total of 14.9 million EUR from the EU Horizon 2020. The project is working to find efficient ways to deliver protein coding mRNA by using various nanoparticles for the treatment of breast cancer and myocardial infarction, which are two of the most pressing health challenges in European society today. Prof. Dan Peer, Director, Laboratory of Precision NanoMedicine, School of Molecular Cell Biology and Biotechnology, George S. Wise Faculty of Life Sciences and Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University Center for Nanoscience and Nanotechnology and Tel Aviv University Cancer Biology Research Center.

Dan, What is the research about in the EXPERT project?

“It is about developing mRNA therapy for the treatment of breast cancer. Much of it involves testing different methods to improve the delivery of mRNA to cells in vivo. These methods are fundamentally based either on lipid nanoparticles (LNPs), biological nanoparticles called exosomes, or cell penetrating peptides (CPPs). In addition to this, we intend to analyze what these nanoparticles bind to in biological fluids in order to better understand what drives uptake in specific cells types”.

What is your and TAU’s part in the project?

“Our lab was the first to show systemic, cell specific delivery of mRNA molecules that express therapeutic proteins in designated cells. We will further develop our ASSET platform for cell specific targeting of lipid nanoparticles to achieve improved delivery of therapeutic mRNAs and optimize formulations that enable systemic administration in different preclinical models. Part of the work will also consist of understanding how nanoparticle surfaces bind to host factors in blood and how this can affect the uptake of nanoparticles”.

What happens now, what is the next step?

“We will now see how these delivery methods work side by side in cell culture and animal models. The hope is then to be able to deliver an mRNA cocktail with one of the aforementioned vectors for the treatment of triple-negative breast cancer. In parallel, these vectors will also be evaluated for delivery of VEGF mRNA in the treatment of myocardial infarction”.

Related posts

Aerobic Activity can Reduce Risk of Metastatic Cancer by 72%

15 November 2022

4th Covid-19 Vaccine Reduces Risk of Death by 72% Amongst Elderly

21 July 2022

Going to the Beach? Sun Exposure Makes Men Hungrier than Women

19 July 2022

Breakthrough Technology Could Lead to One-Time HIV Treatment

14 June 2022

TAU Researchers Find Gene Mechanism Linked to Autism and Alzheimer’s

26 May 2022

Want to Live Longer? Find Out if You Snore

15 May 2022

TAU Researchers Invent Healthy Weapon Against Covid

15 April 2022

Is the Vaccine Safe? Consult the Smart Sensor!

12 April 2022

TAU Nanodrug Enables 2-in-1 Attack on Cancer

6 April 2022

TAU Welcomes Ukrainian Emergency Fellowship Students

1 April 2022

Prof. Ehud Gazit – First Israeli to Receive Prestigious International Recognition in Chemistry

1 April 2022

Minor Head Injury Leads to Chronic Post-Concussion Syndrome in 1 of 4 Children

29 March 2022

Inventive Study to Develop Biological Solutions for Agriculture

28 March 2022

TAU Technology Could Prevent Repeat Heart Valve Surgery

25 March 2022

Israeli Breakthrough in Treating PTSD

22 February 2022

Discovery May Enable Early Diagnosis of Alzheimer’s

15 February 2022

Victoria

Tok Corporate Centre, Level 1,
459 Toorak Road, Toorak VIC 3142
Phone: +61 3 9296 2065
Email: office@aftau.asn.au

New South Wales

P.O. Box 4044, Maroubra South,
NSW 2035
Phone: +61 418 465 556
Email: davidsolomon@aftau.org.au

Western Australia

P O Box 36, Claremont,
WA  6010
Phone: :+61 411 223 550
Email: clivedonner@thelinqgroup.com